David A. Hill, MD, PhD, FAAP, FACAAI, FAAAAI
Assistant Professor of Pediatrics (Allergy/Immunology)
Member, Institute for Immunology, University of Pennsylvania School of Medicine
Member, Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine
Member, Cardiovascular Institute, University of Pennsylvania School of Medicine
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
Division of Allergy and Immunology
Department of Pediatrics
Abramson Pediatric Research Center, Room 1208B
3615 Civic Center Blvd.
Philadelphia, PA 19104
Division of Allergy and Immunology
Department of Pediatrics
Abramson Pediatric Research Center, Room 1208B
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-590-2549
Fax: 215-590-6849
Lab: 267-426-7777
Fax: 215-590-6849
Lab: 267-426-7777
Publications
Education:
BS (Biological Sciences, with honors)
Carnegie Mellon University, Elizabeth Jones Lab, 2005.
PhD (Cell and Molecular Biology)
University of Pennsylvania School of Medicine, David Artis Lab, 2011.
MD (Medicine)
University of Pennsylvania School of Medicine, 2013.
Permanent linkBS (Biological Sciences, with honors)
Carnegie Mellon University, Elizabeth Jones Lab, 2005.
PhD (Cell and Molecular Biology)
University of Pennsylvania School of Medicine, David Artis Lab, 2011.
MD (Medicine)
University of Pennsylvania School of Medicine, 2013.
Description of Clinical Expertise
Food allergy, eosinophilic esophagitis, obesity-associated asthma.Description of Research Expertise
The Hill Lab investigates how diet and metabolism impact immune health and contribute to inflammatory diseases. Our research focuses on key areas such as food allergies, obesity-associated asthma, and immunometabolism. By integrating clinical epidemiology with mechanistic studies in animal models and patient samples, we aim to uncover the underlying mechanisms that drive immune responses. Our goal is to translate these findings into innovative preventative, diagnostic, and therapeutic strategies to improve human health and combat disease.Selected Publications
Harding L, McCright S, Hill DA: Dietary stearate alters lung myeloid cell metabolism and causes inflammasome-dependent IL-1β cytokine production. AAAAI Annual Meeting Discovery Session. San Deigo, CA. Feb 2025.Clement R, Hill DA: IFNү promotes Treg-derived TGFβ production which exacerbates eosinophilic esophagitis. AAAAI Annual Meeting Discovery Session. San Deigo, CA. Feb 2025.
Dilollo J, Hu A, Qu H, Canziani KE, Clement RL, McCright SJ, Shreffler WG, Hakonarson H, Spergel JM, Cerosaletti K, Hill DA: Characterization of a circulating milk-specific TCR clonotype in a child with EoE milk allergy. AAAAI Annual Meeting. San Deigo, CA. Feb 2025 Notes: Poster presentation.
Dilollo J, Hu A, Qu H, Canziani KE, Clement RL, McCright SJ, Shreffler WG, Hakonarson H, Spergel JM, Cerosaletti K, Hill DA: A molecular basis for milk allergen immune recognition in eosinophilic esophagitis. Journal of Allergy and Clinical Immunology IN PRESS 2025.
Betancourt A, Harding O, Hill DA: Effects of Dietary Saturated Fatty Acid on Macrophage Metabolism. Annual Biomedical Research Conference for Minoritized Scientists (ABRCMS). Pittsburgh, PA. Nov 2024.
Dilollo J, Hu A, Qu H, Canziani KE, Clement RL, McCright SJ, Shreffler WG, Hakonarson H, Spergel JM, Cerosaletti K, Hill DA: Companion to: A molecular basis for milk allergen immune recognition in eosinophilic esophagitis. bioRxiv Nov 2024.
Seshadri N, Faig W, Young LR, Hill DA: Risk Factors for Hospitalization in Subspecialty Patients with Severe Persistent Asthma. Respiratory Medicine 235: 107867, Nov 2024.
Wright BL, Abonia JP, Abud EM, Aceves SS, Ackerman SJ, Braskett M, Chang JW, Chehade M, Constantine GM, Davis CM, Dellon ES, Doyle AD, Durban R, Hill DA, Jensen ET, Kewalramani A, Khoury P, Klion AD, Kottyan L, Kuang FL, McGowan EC, Ruffner MA, Spencer LA, Spergel JM, Uchida AM, Wechsler JB, Pesek RD: Advances and Ongoing Challenges in Eosinophilic Gastrointestinal Disorders presented at the CEGIR/TIGERS Symposium at the 2024 American Academy of Allergy, Asthma, & Immunology Meeting. Journal of Allergy and Clinical Immunology 154(4): 882-892, Oct 2024.
Gabryszewski SJ, Hill DA, Spergel JM: The Atopic March. World Allergy Association Page: In Press, Aug 2024.
Paneru BD, Chini J, McCright SJ, DeMarco N, Miller J, Joannas LD, Henao-Mejia J, Titchenell PM, Merrick DM, Lim HW, Lazar MA, Hill DA: Myeloid-derived miR-6236 potentiates adipocyte insulin signaling and prevents hyperglycemia during obesity. Nature Communications 15(1): 5394, Jun 2024.