INDICATION CRENESSITY (crinecerfont) is indicated as adjunctive treatment to glucocorticoid replacement to control androgens in adults and pediatric patients 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

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Redefine what's possible with CAH

CRENESSITY can address the long-standing challenges of classic CAH by lowering androgens and allowing for GC dose reductions in both adults and children.1-3

Explore efficacy & safety outcomesDiscover GC down-titration support
Explore efficacy & safety outcomesDiscover GC down-titration support

MILESTONE: CRENESSITY Studied Through 12 Months

Continued efficacy and safety observed in the longest and largest-ever classic CAH clinical trial program1,4-8

CRENESSITY is a paradigm shift. I really like the idea that after years we have another option to add for our patients.”

CRENESSITY is a paradigm shift. I really like the idea that after years we have another option to add for our patients.”

Dr. Heidi SheaAdult & Pediatric EndocrinologistCompensated by Neurocrine for sharing her views.

A BREAKTHROUGH TREATMENT

CRENESSITY works toward rebalancing the HPA axis in classic CAH

CRENESSITY improves androgen control and allows for GC dose reductions, enabling a transformational approach to managing classic CAH.1

Demonstrated safety Profile

Studied in pediatric and adult patients1-3

Most common adverse reactions in children taking CRENESSITY were headache, abdominal pain, fatigue, nasal congestion, and epistaxis. Most common adverse reactions in adults taking CRENESSITY were fatigue, headache, dizziness, arthralgia, back pain, decreased appetite, and myalgia.

100% of children taking CRENESSITY completed their phase 3 trials (28-week).96% of adults taking CRENESSITY completed their phase 3 trials (24-week).
  • *A total of 3% of children treated with CRENESSITY and no placebo-treated patients discontinued treatment because of adverse reactions of abdominal pain, myalgia, and dizziness. A total of 3% of adults treated with CRENESSITY and no placebo-treated patients discontinued treatment because of adverse reactions of restlessness, apathy, dyspepsia, nausea, and vomiting. One adult discontinued during the randomized phase. Three additional adults and two children discontinued after the randomized phase. One additional patient withdrew from CAHtalystTM Pediatric.
100% of children taking CRENESSITY completed their phase 3 trials (28-week).96% of adults taking CRENESSITY completed their phase 3 trials (24-week).

ACCESS SIMPLIFIED

Dedicated support for those prescribed CRENESSITY

Personalized support at every step to ensure timely access, with most patients paying $10 or less a month for CRENESSITY.*

  • *Additional terms and conditions apply.
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Actor portrayals.

PeerConnect

Connect with other colleagues who treat CAH to consult, collaborate, or transition care.

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ACTH=adrenocorticotropic hormone; CAH=congenital adrenal hyperplasia; GC=glucocorticoid; HPA=hypothalamic-pituitary-adrenal.

REFERENCES

INDICATION

CRENESSITY (crinecerfont) is indicated as adjunctive treatment to glucocorticoid replacement to control androgens in adults and pediatric patients 4 years of age and older with classic congenital adrenal hyperplasia (CAH).

IMPORTANT SAFETY INFORMATION

CONTRAINDICATIONS

CRENESSITY is contraindicated in patients with hypersensitivity to crinecerfont or any excipients of CRENESSITY.

WARNINGS AND PRECAUTIONS

Hypersensitivity Reactions. A hypersensitivity reaction, including throat tightness, angioedema, and generalized rash, occurred in a subject after 3 days of treatment with CRENESSITY. If a clinically significant hypersensitivity reaction occurs, initiate appropriate therapy and discontinue CRENESSITY.

Risk of Acute Adrenal Insufficiency or Adrenal Crisis with Inadequate Concomitant Glucocorticoid Therapy. Acute adrenal insufficiency or adrenal crisis, which is potentially life-threatening, can occur in patients with underlying adrenal insufficiency who are on inadequate daily glucocorticoid doses, especially in situations associated with increased cortisol need, such as acute intercurrent illness, serious trauma, or surgical procedures. Continue glucocorticoids upon initiation of and during treatment with CRENESSITY. Do not reduce the glucocorticoid dose below the dose required for cortisol replacement. Patients should continue to use stress dosing of glucocorticoids in cases of increased cortisol need.

ADVERSE REACTIONS

In adult patients, the most common adverse reactions (at least 4% for CRENESSITY and greater than placebo) are fatigue, headache, dizziness, arthralgia, back pain, decreased appetite, and myalgia.

In pediatric patients, the most common adverse reactions (at least 4% for CRENESSITY and greater than placebo) are headache, abdominal pain, fatigue, nasal congestion, and epistaxis.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088.

Dosage Forms and Strengths:

CRENESSITY is available in 50 mg and 100 mg capsules, and as an oral solution of 50 mg/mL.

Please see full Prescribing Information.