My name is Barney Hill.

I am focused on making genetic medicines accessible for the 300M individuals with a disease-causing mutation in one of their genes.

My thesis is based on the belief that as RNA therapeutics are the simplest form of drug we have, they should be the simplest to model.

In the first year of my DPhil, I showed that we can ~5x reduce the initial screening burden of antisense oligonucleotides with an accurate model of how effectively they cleave genes in cells (see: Accurately modelling RNase H-mediated antisense oligonucleotide efficacy).

I am now working on a unified antisense oligonucleotide model to predict outcomes across the entire preclinical pipeline, with the goal of substantially reducing preclinical development costs.

I also help run In Silico, a biomolecular design meet-up in London [#001, #002, #003, #004]. If you are working in this space, I would love to meet.

Side projects

• London Microgrants (2025-)

  Microgrants for a vibrant London.

• Scientific Interface & Tooling Lab (2025-)

  AI for science lab.

• Loading... (2024-2025)

  A zine pairing CSM art students & Oxford biology DPhils.

• genoRxiv (2024)

  Mapping scientific literature on the genome.

• Genomie! (2024)

  A genome browser you can talk to.

• epitomē (2024)

  A semantic search engine for ancient text.

• Field* (2024)

  A UMAP of music.

• Vroom Live (2024)

  Chat with your Ableton Live session.

• NTS Tracklists (2023)

  Browse nts.live tracklists linked by common tracks.

• Vroom VST (2023)

  Generate sounds from words. Directly in your DAW.

• minBERT (2023)

  A minimal implementation of the BERT LLM model.

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