George Mason and Patrick Henry were 2 of the main ones. (Patrick Henry was the main leader). Thomas Jefferson and Elbridge Gerry were also antifederalists.
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Why did Antifederalists oppose Alexander Hamilton's plan
Of Individual Rights
By making the Bill of Rights.
The most notable antifederalist from Virginia is Patrick Henry. Henry was invited to the Continental Congress but opted out in order to fight the new Constitution from the outside. Other antifederalists from Virginia include George Mason, a drafter of the Bill of Rights and Richard Henry Lee, drafter of the Declaration and a later Senator.
Because they feared that a too-strong central government, would wipe out state powers and individual freedom.