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Figure from:Medial auditory thalamic stimulation as a conditioned stimulus for eyeblink conditioning in rats

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The conditioning seen in rats given paired presentations of auditory thalamic stimulation and a peripheral US indicates that activation of the medial auditory thalamus is sufficient for estab- lishing associative eyeblink conditioning in rats. Moreover, rats in the paired group showed a rate of acquisition that was sub-

Figure 5 The conditioning seen in rats given paired presentations of auditory thalamic stimulation and a peripheral US indicates that activation of the medial auditory thalamus is sufficient for estab- lishing associative eyeblink conditioning in rats. Moreover, rats in the paired group showed a rate of acquisition that was sub-

Related Figures (6)

Figure 1. Medial auditory thalamic stimulation as a conditioned stimu- lus supports associative eyeblink conditioning. Mean conditioned re- sponse (CR) percentage for rats with accurately placed electrodes given paired (black circles) or unpaired training (white circles), rats given in- tentionally misplaced electrodes (black triangles), and rats given inferior colliculus lesions (gray squares) across 30 10-trial blocks of trials. The vertical dashed lines indicate breaks between daily training sessions. ‘The effects described above were confirmed by an ANOVA that revealed a significant effect of the group factor, F313) = 67.15, P < 0.001. Post hoc tests showed that the control
Figure 1. Medial auditory thalamic stimulation as a conditioned stimu- lus supports associative eyeblink conditioning. Mean conditioned re- sponse (CR) percentage for rats with accurately placed electrodes given paired (black circles) or unpaired training (white circles), rats given in- tentionally misplaced electrodes (black triangles), and rats given inferior colliculus lesions (gray squares) across 30 10-trial blocks of trials. The vertical dashed lines indicate breaks between daily training sessions. ‘The effects described above were confirmed by an ANOVA that revealed a significant effect of the group factor, F313) = 67.15, P < 0.001. Post hoc tests showed that the control
Figure 2. Electrode placements. The tips of stimulation electrodes in the control rats given paired (black circles) or unpaired (gray circles) training were in or within 0.2 mm of the medial division of the medial geniculate (left). Rats given intentionally misplaced electrodes had tip placements 1.0 mm medial and lateral to the medial division of the medial geniculate (right). Numbers indicate the anterior-posterior stereo- taxic coordinates of the sections relative to bregma (This figure was re- produced with permission from Elsevier © 1998, Paxinos and Watson 1998).
Figure 2. Electrode placements. The tips of stimulation electrodes in the control rats given paired (black circles) or unpaired (gray circles) training were in or within 0.2 mm of the medial division of the medial geniculate (left). Rats given intentionally misplaced electrodes had tip placements 1.0 mm medial and lateral to the medial division of the medial geniculate (right). Numbers indicate the anterior-posterior stereo- taxic coordinates of the sections relative to bregma (This figure was re- produced with permission from Elsevier © 1998, Paxinos and Watson 1998).
Figure 3. Inferior colliculus (IC) lesions. The largest (gray shaded areas) and smallest (black shaded areas) unilateral lesions of the IC. The lesions were ipsilateral to the MATN stimulation electrode (contralateral to the conditioned eye). Numbers indicate the anterior-posterior stereotaxic co- ordinates of the sections relative to bregma (This figure was reproduced with permission from Elsevier © 1998, Paxinos and Watson 1998).
Figure 3. Inferior colliculus (IC) lesions. The largest (gray shaded areas) and smallest (black shaded areas) unilateral lesions of the IC. The lesions were ipsilateral to the MATN stimulation electrode (contralateral to the conditioned eye). Numbers indicate the anterior-posterior stereotaxic co- ordinates of the sections relative to bregma (This figure was reproduced with permission from Elsevier © 1998, Paxinos and Watson 1998).
Figure 4. BDA labeling in the pontine nuclei and inferior colliculus following injection into the medial auditory thalamus. (A) Representative BDA injection site (arrows) within the suprageniculate (SG), medial nucleus of the medial geniculate (MGm), and posterior intralaminar nucleus (PIN). (MGd) dorsal medial geniculate; (MGv) ventral medial geniculate. Scale bar, 500 um. (B) Anterograde (arrows) and retrograde labeling in the ipsilateral anterior external inferior colliculus. Scale bar, 250 um. (C) Anterograde labeling (arrows) within the ipsilateral basal pontine nuclei, which are outlined by the dashed line. Scale bar, 500 um. (D) Higher magnification view of anterograde labeling in the lateral pon- tine nucleus. Scale bar, 125 um.
Figure 4. BDA labeling in the pontine nuclei and inferior colliculus following injection into the medial auditory thalamus. (A) Representative BDA injection site (arrows) within the suprageniculate (SG), medial nucleus of the medial geniculate (MGm), and posterior intralaminar nucleus (PIN). (MGd) dorsal medial geniculate; (MGv) ventral medial geniculate. Scale bar, 500 um. (B) Anterograde (arrows) and retrograde labeling in the ipsilateral anterior external inferior colliculus. Scale bar, 250 um. (C) Anterograde labeling (arrows) within the ipsilateral basal pontine nuclei, which are outlined by the dashed line. Scale bar, 500 um. (D) Higher magnification view of anterograde labeling in the lateral pon- tine nucleus. Scale bar, 125 um.
Figure 6. FG labeling in the cochlear nuclei, inferior colliculus, and cerebral cortex. (A) Retrograde labeling of neurons in the contralateral ventral cochlear nucleus (arrow). (B) Retrograde labeling of neurons in the ipsilateral anterior external inferior colliculus. (CQ) Retrograde labeling of neurons in the ipsilateral motor cortex. Scale bars, 500 um.
Figure 6. FG labeling in the cochlear nuclei, inferior colliculus, and cerebral cortex. (A) Retrograde labeling of neurons in the contralateral ventral cochlear nucleus (arrow). (B) Retrograde labeling of neurons in the ipsilateral anterior external inferior colliculus. (CQ) Retrograde labeling of neurons in the ipsilateral motor cortex. Scale bars, 500 um.
Figure 7. FG labeling in the anterior pretectal nucleus, periaqueductal gray, and superior colliculus. (A) Retrograde labeling (arrows) of neurons in the superior colliculus (SC) and periaqueductal gray (PAG). Scale bar, 250 um. (B) Retrograde labeling of neurons in the anterior pretectal nucleus (APT). Scale bar, 250 um.
Figure 7. FG labeling in the anterior pretectal nucleus, periaqueductal gray, and superior colliculus. (A) Retrograde labeling (arrows) of neurons in the superior colliculus (SC) and periaqueductal gray (PAG). Scale bar, 250 um. (B) Retrograde labeling of neurons in the anterior pretectal nucleus (APT). Scale bar, 250 um.