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Fig. 1 Schematic structure of influenza virion: Hemagglutinin (HA) and neuraminidase (NA) are surface proteins present at an approxi- mate 3:1 ratio along with M2 ion channels. M1 is the matrix protein  The ability for the virus to cross species barrier is multi- factorial (Fig. 2). The presence of intermediate host (viz. pigs) where it acts as a genetic mixing vessel among humans and birds, along with host susceptibility, exposure level to infected avian species, viral mutations, environmental con- ditions conducive for virus transmission are essential for transmission [8, 42]. Pigs and birds have been implicated

Figure 1 Schematic structure of influenza virion: Hemagglutinin (HA) and neuraminidase (NA) are surface proteins present at an approxi- mate 3:1 ratio along with M2 ion channels. M1 is the matrix protein The ability for the virus to cross species barrier is multi- factorial (Fig. 2). The presence of intermediate host (viz. pigs) where it acts as a genetic mixing vessel among humans and birds, along with host susceptibility, exposure level to infected avian species, viral mutations, environmental con- ditions conducive for virus transmission are essential for transmission [8, 42]. Pigs and birds have been implicated