Science

Further important sources of the empiricism of the Scientific Revolution were to be found in the magical tradition, and these influences can be seen at work in a number of areas. They deserve separate consideration here, however, because they have generated considerable historiographical debate [222; 39]. A number of historians of science have refused to accept that something which they see as so irrational could have had any impact whatsoever upon the supremely rational pursuit of science. Their arguments seem to be based on mere prejudice, or on a failure to understand the richness and complexity of the magical tradition.

10. DC cultures were generated as described (5, 22). Immature I-A kϩ DCs grown from C3H/HeN, C3H/HeJ, and CBA/J (Jackson Labs, Bar Harbor, ME) marrow suspensions were pulsed with HEL (1 to 3 mg/ml) with or without LPS (1 to 10 ng/ml, E. coli 0111.B4) for 1 to 3 hours, washed, and chased in HEL-and LPS-free media. Similar results were obtained with DCs from each strain. DC cultures contained supernatant from mGM-CSFexpressing J558L cells (from A. Lanzavecchia, Basel Institute, Basel, Switzerland). LPS was removed from HEL (Sigma) with Kuttsuclean adsorbent (Maruha Corporation, Ibaraki, Japan). Maturation stimuli included LPS, CD40L, tumor necrosis factor-␣, or replating (22). 11. DCs were fixed with 4% (wt/vol) paraformaldehyde and washed in phosphate-buffered saline. Cells were incubated with monoclonal antibodies (mAbs) on ice as described (23). The rat mAb C4H3 was provided by R. Germain (NIH, Bethesda, MD). C4H3 was purified on protein A-Sepharose and biotinylated. Cells were labeled with biotin-conjugated mAbs (Pharmingen) to I-E k (14-4-4S) or I-A k (10-2.16) and fluorescein

Knowledge is material and angular.
Nonhuman animals often shape their material round. Perhaps: The hexagon of bees is
between round (Das Runde) and angular (Das Eckige) . Dancing knowledge.
Water is round. The knowledge of the octopus: materialized by the body – ink to the
outside. Blue clouds. Human animals materialize knowledge often angular.

One of the most influential alchemical authors of the early modern period was Michael Sendivogius whose early life is shrouded in mystery. He may be labelled the most famous Polish scientific writer between Copernicus and Marie Skłodowska-Curie, but because of the difficulties involved in researching the biography of any alchemist, there has been relatively little interest in him among Polish historians. The early work of Roman Bugaj (author of the still fundamental monograph) and Włodzimierz Hubicki (who made his research available to the international community) has been continued only by the English-born Zbigniew Szydło and the author of this article. The roots of many legends about Sendivogius were three mid-17th century short biographies, none of which is trustworthy, so it is crucial to verify the received myth and the version constructed in the 1960's and 1970's with primary sources and evidence from the recent "new historiography of alchemy". The present ar...

It is a precious knowledge of ancient india. this script was originally composed by mahrshi BHARADWAJA, the great indian sage around 5000 BC  ,it content english transtation of some of its sanskrit stotras and shlokas.before wright brothers first aircraft was made by dr Talpade was an Indian scholar who is said to have constructed and flown an unmanned airplane in 1895 with reference of this ancient hindu sanskrit manuscript .

The charged quantum geometry of mass-ENERGY-Matter - developed from the foundational postulate that quantised angular momenta of Planck's constant is in fact reflective of an equilateral mass-energy geometry from which all 2d immaterial EM fields and 3D material particles are created.

feldspar group under high simultaneous pressures of water and carbon dioxide a t elevated temperatures, is described extensively under consideration of the latest developments in this field. A detailed analysis of the silicate hydrates of the Zeolite and Permutit group also covers the dehydration of silicate hydrates and the various types of water binding.

Consistency in conservation Marine protected areas (MPAs) are now well established globally as tools for conservation, for enhancing marine biodiversity, and for promoting sustainable fisheries. That said, which regions are labeled as MPAs varies substantially, from those that full protect marine species and prohibit human extraction to those that permit everything from intensive fishing to mining. This inconsistency can in some cases inhibit both conservation and quantifying the proportion of the marine environment that is truly protected. Grorud-Colvert et al . review the consistency of MPAs and propose a framework by which levels of protection can be evaluated and improved. —SNV

Opioids target the μ-opioid receptor (MOR) to produce unrivaled pain management but their addictive properties can lead to severe abuse. We developed a whole animal behavioral platform for unbiased discovery of genes influencing opioid responsiveness. Using forward genetics in C. elegans, we identified a conserved orphan receptor, GPR139, with anti-opioid activity. GPR139 is coexpressed with MOR in opioid-sensitive brain circuits, binds to MOR and inhibits signaling to G proteins. Deletion of GPR139 in mice enhanced opioid-induced inhibition of neuronal firing to modulate morphine-induced analgesia, reward, and withdrawal. Thus, GPR139 could be a useful target for increasing opioid safety. These results also demonstrate the potential of C. elegans as a scalable platform for genetic discovery of GPCR signaling principles.

The main objective of this research is theoretical and experimental investigation of the surfaces modification of SU8, PDMS, SiO2 and Si by RF plasma treatment. Physical-chemical reactions at room temperature can be used for the modifications of the surfaces in plasma, by modifying the contact angle, superficial polymerization, or by creating hydrophilic and/or hydrophobic regions on the surfaces in contact with plasma. The argon-plasma annealing was used for generate the hydrophilic surfaces, and plasma of CF4 or CF4 with O2 has been used for creating of the hydrophobic surfaces.

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Sažetak: Altiserov neosporni doprinos istoriji marksizma je u tome što je pokazao da apstraktan filozofski diksurs o čoveku, njegovom otuđenju i razotuđenju (oslobođenju), koji je dominirao i dotadašnjom marksističkom filozofijom, predstavlja ozbiljnu prepreku za jednu radikalnu teorijsku i političku praksu. Naime, takav humanizam previđa suštinski značaj klasne borbe i klasne analize. On je s pravom ukazao i na odsustvo razvijene teorije ideologije u marksističkoj filozofiji, ispravno kritikujući neke ograničenosti Marksovog shvatanja ideologije. Ipak, njegov krajnji stav da ideologija ostaje trajan element društvene stvarnosti, tj. da je nužna za svako, a ne samo klasno društvo, nije prihvatljiv. On negira mogućnost da čovek ovlada strukturama svog društvenog života; one neminovno dominiraju nad životom i svešću pojedinaca, uprkos iščezavanju klasnih odnosa eksploatacije. Uticaj strukturalizma dolazi ovde do punog izražaja: subjekti su zahvaćeni anonimnim objektivnim strukturama, a njihova svest (subjektivnost) samo je učinak delovanja (ideoloških) struktura. Strukturalizam kod Altisera odnosi tako prevagu nad Marks(izm)om. Čini se stoga da Altiserova teorija ideologije, koja projektuje otuđenu podelu rada i postojanje ideologije i u samo besklasno društvo, u krajnjem završava kao jedna teorijska ideologija. Ključne reči: ideologija, marksizam, strukturalizam, humanizam, materijalizam, idealizam, nauka, utopija, kritika, revolucija, (bes)klasno društvo Summary: Altiserov unquestionable contribution to the history of Marxism is in prove that an abstract philosophical discourse about the man, his alienation and de-alienation (liberation), which was dominant in the Marxist philosophy too, is a serious obstacle to a radical theoretical and political practice. Namely, such a humanism overlooks the crucial importance of class struggle and class analysis. He also rightly pointed to the lack of developed theory of ideology in Marxist philosophy, properly criticized some of the limitations of Marx's conception of ideology. However, his ultimate position that ideology remains a permanent element of social reality, ie. it is a necessary for each, not just a class society, is unacceptable. He denies the possibility that man can overmaster the structures of his social life; they inevitably dominate the life and consciousness of individuals, despite the disappearance of class relations of exploitation. The influence of structuralism comes here to the fore: the subjects are affected by anonymous objective structures, and their consciousness (subjectivity) is just the effect of action of these (ideological) structures. So, structuralism prevails Marx(ism) in Althusser’s thought. It appears therefore that Althusser's theory of ideology, which projects the alienated division of labor and the existence of ideology in a classless society too, ultimately ends up as a theoretical ideology. Key words: ideology, Marxism, structuralism, humanism, materialism, idealism, science, utopia, criticism, revolution, class(less) society

The present study examined the role of attributions to discrimination and competence in predicting depression among a sample of 93 Latino/a adults. The major findings showed that attributions to discrimination were related to decreases in both general competence and intercultural competence, which were in turn associated with increases in depressive symptoms. This pattern of results suggests that general and intercultural competence partially mediated the relationship between attributions to discrimination and depression. The findings are discussed within the context of the cultural adaptation process and factors that ameliorate Latino/a mental health. In addition, theoretical and practical implications are outlined along with areas of future research.

Lignin is a major component of plant secondary cell walls. Here we describe caffeoyl shikimate esterase (CSE) as an enzyme central to the lignin biosynthetic pathway. Arabidopsis thaliana cse mutants deposit less lignin than do wild-type plants, and the remaining lignin is enriched in p-hydroxyphenyl units. Phenolic metabolite profiling identified accumulation of the lignin pathway intermediate caffeoyl shikimate in cse mutants as compared to caffeoyl shikimate levels in the wild type, suggesting caffeoyl shikimate as a substrate for CSE. Accordingly, recombinant CSE hydrolyzed caffeoyl shikimate into caffeate. Associated with the changes in lignin, the conversion of cellulose to glucose in cse mutants increased up to fourfold as compared to that in the wild type upon saccharification without pretreatment. Collectively, these data necessitate the revision of currently accepted models of the lignin biosynthetic pathway.

The allohexaploid bread wheat genome consists of three closely related subgenomes (A, B, and D), but a clear understanding of their phylogenetic history has been lacking. We used genome assemblies of bread wheat and five diploid relatives to analyze genome-wide samples of gene trees, as well as to estimate evolutionary relatedness and divergence times. We show that the A and B genomes diverged from a common ancestor ~7 million years ago and that these genomes gave rise to the D genome through homoploid hybrid speciation 1 to 2 million years later. Our findings imply that the present-day bread wheat genome is a product of multiple rounds of hybrid speciation (homoploid and polyploid) and lay the foundation for a new framework for understanding the wheat genome as a multilevel phylogenetic mosaic.

The suspension-feeding metazoan subkingdom Lophophorata exhibits characteristics of both deuterostomes and protostomes. Because the morphology and embryology of lophophorates are phylogenetically ambiguous, their origin is a major unsolved problem of metazoan phylogenetics. The complete 18S ribosomal DNA sequences of all three lophophorate phyla were obtained and analyzed to clarify the phylogenetic relationships of this subkingdom. Sequence analyses show that lophophorates are protostomes closely related to mollusks and annelids. This conclusion deviates from the commonly held view of deuterostome affinity.

Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mechanisms: contact ...

We examined possible explanations for the underrepresentation of women among university faculty, in two different national contexts. In the Netherlands, a sample of doctoral students (N = 132) revealed no gender differences in work commitment or work satisfaction. Faculty members in the same university (N = 179), however, perceived female students to be less committed to their work and female faculty endorsed these gender-stereotypical perceptions most strongly. A second study, in Italy, replicated and extended these findings. Again no gender differences were obtained in the self-descriptions of male and female doctoral students (N = 80), while especially the female faculty (N = 93) perceived female students as less committed to their work than male students. Additional measures supported an explanation in social identity terms, according to which individual upward mobility (i.e. of female faculty) implies distancing the self from the group stereotype which not only involves perceiving the self as a non-prototypical group member, but may also elicit stereotypical views of other in-group members.

Going to Mars The Mars Science Laboratory spacecraft containing the Curiosity rover, was launched from Earth in November 2011 and arrived at Gale crater on Mars in August 2012. Zeitlin et al. (p. 1080 ) report measurements of the energetic particle radiation environment inside the spacecraft during its cruise to Mars, confirming the hazard likely to be posed by this radiation to astronauts on a future potential trip to Mars. Williams et al. (p. 1068 , see the Perspective by Jerolmack ) report the detection of sedimentary conglomerates (pebbles mixed with sand and turned to rock) at Gale crater. The rounding of the rocks suggests abrasion of the pebbles as they were transported by flowing water several kilometers or more from their source.

The importance of comets for the origin of life on Earth has been advocated for many decades. Amino acids are key ingredients in chemistry, leading to life as we know it. Many primitive meteorites contain amino acids, and it is generally believed that these are formed by aqueous alterations. In the collector aerogel and foil samples of the Stardust mission after the flyby at comet Wild 2, the simplest form of amino acids, glycine, has been found together with precursor molecules methylamine and ethylamine. Because of contamination issues of the samples, a cometary origin was deduced from the (13)C isotopic signature. We report the presence of volatile glycine accompanied by methylamine and ethylamine in the coma of 67P/Churyumov-Gerasimenko measured by the ROSINA (Rosetta Orbiter Spectrometer for Ion and Neutral Analysis) mass spectrometer, confirming the Stardust results. Together with the detection of phosphorus and a multitude of organic molecules, this result demonstrates that c...

At the core of the "proton radius puzzle" is a four-standard deviation discrepancy between the proton root-mean-square charge radii () determined from the regular hydrogen (H) and the muonic hydrogen (µp) atoms. Using a cryogenic beam of H atoms, we measured the 2S-4P transition frequency in H, yielding the values of the Rydberg constant= 10973731.568076(96) per meterand= 0.8335(95) femtometer. Ourvalue is 3.3 combined standard deviations smaller than the previous H world data, but in good agreement with the µp value. We motivate an asymmetric fit function, which eliminates line shifts from quantum interference of neighboring atomic resonances.

Resistance to insecticides and herbicides has cost billions of U.S. dollars in the agricultural sector and could result in millions of lives lost to insect-vectored diseases. We mostly continue to use pesticides as if resistance is a temporary issue that will be addressed by commercialization of new pesticides with novel modes of action. However, current evidence suggests that insect and weed evolution may outstrip our ability to replace outmoded chemicals and other control mechanisms. To avoid this outcome, we must address the mix of ecological, genetic, economic, and sociopolitical factors that prevent implementation of sustainable pest management practices. We offer an ambitious proposition.

This paper introduces historical aspects of the concepts correspondence and coherence with emphasis on the nineteenth century when key aspects of modern science were emerging. It is not intended to be a definitive history of the concepts of correspondence and coherence as they have been used across the centuries in the field of inquiry that we now call science. Rather it is a brief history that highlights the apparent origins of the concepts and provides a discussion of how these concepts contributed to two important science related controversies. The first relates to aspects of evolution in which correspondence and coherence, as competing theories of truth, played a central role. The controversy about evolution continues into the beginning of the twenty-first century in forms that are recognizably similar to those of the middle of the nineteenth century. The second controversy relates to the etiology of blood-born infections (sepsis) during childbirth (childbed fever). In addition to correspondence and coherence, the authors introduce other theories of truth and discuss an evolutionarily cogent theory of truth, the pragmatic theory of truth.

31. We thank the officers and crew of the R/V Knorr for their outstanding support during the transatlantic VPR sampling. B. Walden provided facilities support for use of the VPR. F. Thwaites, A. Girard, and M. Alberico assisted in system deployment and operations. V. Kosnyrev provided daily altimetry maps and eddy positions to the ship based on data streams provided by R. Leben. J. Hummon processed the ship's acoustic Doppler current profiler data. We thank D. Capone, E. Carpenter, J. Waterbury, P. Falkowski, S. Dyhrman, E. Webb, and two anonymous reviewers for their helpful comments on this paper.

The superior capability of cognitive experts largely depends on quick automatic processes. To reveal their neural bases, we used functional magnetic resonance imaging to study brain activity of professional and amateur players in a board game named shogi. We found two activations specific to professionals: one in the precuneus of the parietal lobe during perception of board patterns, and the other in the caudate nucleus of the basal ganglia during quick generation of the best next move. Activities at these two sites covaried in relevant tasks. These results suggest that the precuneus-caudate circuit implements the automatic, yet complicated, processes of board-pattern perception and next-move generation in board game experts.

Over the past 5 years, parts of Oklahoma have experienced marked increases in the number of small- to moderate-sized earthquakes. In three study areas that encompass the vast majority of the recent seismicity, we show that the increases in seismicity follow 5- to 10-fold increases in the rates of saltwater disposal. Adjacent areas where there has been relatively little saltwater disposal have had comparatively few recent earthquakes. In the areas of seismic activity, the saltwater disposal principally comes from “produced” water, saline pore water that is coproduced with oil and then injected into deeper sedimentary formations. These formations appear to be in hydraulic communication with potentially active faults in crystalline basement, where nearly all the earthquakes are occurring. Although most of the recent earthquakes have posed little danger to the public, the possibility of triggering damaging earthquakes on potentially active basement faults cannot be discounted.