Neural correlates of consciousness

This paper evaluates recent advancements in the debate on animal consciousness, comparing the marker hypothesis with the universal consciousness hypothesis. It discusses the use of consciousness tests (C-tests) for identifying conscious beings, a method supported by Bayne et al.’ s (2024) and compares this with Andrews's (2024) call for assuming all animals are conscious. The paper argues for a balanced approach to studying consciousness that acknowledges species-specific consciousness without relying solely on C-tests. It suggests Dung and Newen's (2023) framework as a synthesis of these views, offering a method that combines scientific rigour with ethical considerations.

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Objective: A main feature of schizophrenic thought and language disturbance is concretism, the inability to understand the figurative meaning of proverbs and metaphors. Although this is routinely tested during clinical interview, its neural basis is unknown. Method: We investigated processing of metaphoric sentences with functional magnetic resonance imaging (fMRI) in 12 patients with schizophrenia and 12 control subjects. Stimuli consisted of 60 novel short sentences with either metaphoric or literal meaning presented visually, intersparsed by a low level baseline (grey background). Subjects read these sentences silently and judged by button press whether they had a positive or negative connotation. Results: Reading metaphors in contrast to literal sentences revealed signal changes in the left inferior frontal gyrus in the control subjects (BA 45/47) and an area 3 cm dorsal to that in the patients (BA 45). Only activation in this area was negatively correlated with the severity of concretism rated with the PANSS. Comparison between groups for the contrast metaphors vs. low level baseline revealed stronger signal changes in the control group in the right superior/middle temporal gyrus (BA 39) and the left inferior frontal gyrus (BA 45) in the patients. Conclusions: The results in the control subjects are in line with studies showing an involvement of the left inferior frontal and right lateral temporal cortex during context processing. Failure to recruit these areas in the patients may underlie schizophrenic concretism.

Social support modulates subjective and neural responses to sad mental imagery Jakub Kraus (Conceptualization) (Methodology) (Investigation) (Formal analysis) (Writing -review and editing) (Visualization), Robert Roman (Funding acquisition) (Supervision), Lenka Jurkovičov á (Investigation), Radek Mareček (Software) (Data curation), Michal Mikl (Software) (Data curation), Milan Br ázdil (Funding acquisition), Andreas Frick (Formal analysis) (Supervision) (Writing -review and editing)

Social touch may modulate emotions, but the neurobehavioral correlates are poorly understood. Here, we investigated neural responses to a picture of a deceased close person and if neural activity and connectivity are modulated by social touch from one’s romantic partner. Using functional magnetic resonance imaging, we found altered reactivity in several brain areas including the anterior cingulate cortex (ACC) and the anterior insula in response to the personal picture compared to a picture of an unfamiliar person. Hand holding with the romantic partner, compared to being alone, reduced reactivity in the ACC and cerebellum and provided subjective comfort. To separate physical touch from the emotional effect of partner presence, we evaluated hand holding with the partner relative to a stranger and found reduced reactivity in the anterior insula. Connectivity between the anterior insula and the ACC was reduced during partner touch, and the connectivity strength was negatively related ...

Background Interpersonal difficulties of patients with borderline personality disorder (BPD) are closely related to rejection sensitivity. The aim of the present study was to gain further insight into the experience and cerebral processing of social interactions in patients with BPD by using fMRI during experimentally induced experiences of social exclusion, inclusion, and overinclusion. The study involved 30 participants diagnosed with BPD (29 female and 1 male; age: M = 24.22, SD = 5.22) and 30 healthy controls (29 female and 1 male; age: M = 24.66, SD = 5.28) with no current or lifetime psychiatric diagnoses. In the fMRI session, all participants were asked to complete a Cyberball task that consisted of an alternating sequence of inclusion, exclusion, and overinclusion conditions. Compared to healthy controls, participants with BPD reported higher levels of inner tension and more unpleasant emotions across all experimental conditions. At the neural level, the participants with BPD showed lower recruitment of the left hippocampus in response to social exclusion (relative to the inclusion condition) than the healthy controls did. Lower recruitment of the left hippocampus in this contrast was associated with childhood maltreatment in patients with BPD. However, this difference was no longer significant when we added the covariate of hippocampal volume to the analysis. During social overinclusion (relative to the inclusion condition), we observed no significant differences in a group comparison of neural activation. The results of our study suggest that patients with BPD experience more discomfort than do healthy controls during social interactions. Compared to healthy participants, patients with BPD reported more inner tension and unpleasant emotions, irrespective of the extent to which others included them in social interactions. At a neural level, the participants with BPD showed a lower recruitment of the left hippocampus in response to social exclusion than the healthy controls did. The reduced activation of this neural structure could be related to a history of childhood maltreatment and smaller hippocampal volume in patients with BPD.

An increasing number of studies suggest that implicit attitudes towards food and body shape predict eating behaviour and characterize patients with eating disorders (EDs). However, literature has not been previously analysed; thus, differences between patients with EDs and healthy controls and the level of automaticity of the processes involved in implicit attitudes are still matters of debate. The present systematic review aimed to synthesize current evidence from papers investigating implicit attitudes towards food and body in healthy and ED populations. PubMed, EMBASE (Ovid), PsycINFO, Web of Science and Scopus were systematically screened and 183 studies using different indirect paradigms were included in the qualitative analysis. The majority of studies reported negative attitudes towards overweight/obese body images in healthy and ED samples and weight bias as a diffuse stereotypical evaluation. Implicit food attitudes are consistently reported as valid predictors of eating be...

Divergent findings exist whether left and right hemispheric pre- and postcentral cortices contribute to the production of tool use related hand movements. In order to clarify the neural substrates of tool use demonstrations with tool in hand, tool use pantomimes without tool in hand, and body-part-as-object presentations of tool use (BPO) in a naturalistic mode of execution, we applied functional Near InfraRed Spectroscopy (fNIRS) in twenty-three right-handed participants. Functional NIRS techniques allow for the investigation of brain oxygenation during the execution of complex hand movements with an unlimited movement range. Brain oxygenation patterns were retrieved from 16 channels of measurement above pre- and postcentral cortices of each hemisphere. The results showed that tool use demonstration with tool in hand leads to increased oxygenation as compared to tool use pantomimes in the left hemispheric somatosensory gyrus. Left hand executions of the demonstration of tool use, p...

Cognitive reappraisal has been associated with increased activation in prefrontal cortex (PFC) and cingulate regions implicated in cognitive control and affect regulation. To date, neuroimaging studies of reappraisal have primarily used emotionally evocative scenes, and it remains unclear whether the same cognitive strategy applied to emotional facial expressions would involve similar or different neural underpinnings. The present study used fMRI to examine brain activation during cognitive reappraisal of negatively valenced facial expressions relative to passive viewing of negative and neutral facial expressions. Twenty-two healthy adults completed a cognitive reappraisal task comprised of three different conditions (Look-Neutral, Maintain-Negative, Reappraise-Negative). Results indicated that reappraisal was associated with a decrease in negative affect and engagement of PFC brain regions implicated in cognitive control and affect regulation (DLPFC, mPFC, and VLPFC). Furthermore, individual differences in habitual reappraisal use were associated with greater DLPFC and mPFC activation, while suppression use was associated with greater amygdala activation. The present study provides preliminary evidence that facial expressions are effective alternative 'targets' of prefrontal engagement during cognitive reappraisal. These findings are particularly relevant for future research probing the neural bases of emotion regulation in populations for whom aversive scenes may be less appropriate (e.g., children) and illnesses in which aberrant responses to social signals of threat and negative feedback are cardinal phenotypes.

Observing someone perform an action engages brain regions involved in motor planning, such as the inferior frontal, premotor, and inferior parietal cortices. Recent research suggests that during action observation, activity in these neural regions can be modulated by membership in an ethnic group defined by physical differences. In this study we expanded upon previous research by matching physical similarity of two different social groups and investigating whether likability of an outgroup member modulates activity in neural regions involved in action observation. Seventeen Jewish subjects were familiarized with biographies of eight individuals, half of the individuals belonged to Neo-Nazi groups (dislikable) and half of which did not (likable). All subjects and actors in the stimuli were Caucasian and physically similar. The subjects then viewed videos of actors portraying the characters performing simple motor actions (e.g. grasping a water bottle and raising it to the lips), while undergoing fMRI. Using multivariate pattern analysis (MVPA), we found that a classifier trained on brain activation patterns successfully discriminated between the likable and dislikable action observation conditions within the right ventral premotor cortex. These data indicate that the spatial pattern of activity in action observation related neural regions is modulated by likability even when watching a simple action such as reaching for a cup. These findings lend further support for the notion that social factors such as interpersonal liking modulate perceptual processing in motorrelated cortices.

Observing someone perform an action engages brain regions involved in motor planning, such as the inferior frontal, premotor, and inferior parietal cortices. Recent research suggests that during action observation, activity in these neural regions can be modulated by membership in an ethnic group defined by physical differences. In this study we expanded upon previous research by matching physical similarity of two different social groups and investigating whether likability of an outgroup member modulates activity in neural regions involved in action observation. Seventeen Jewish subjects were familiarized with biographies of eight individuals, half of the individuals belonged to Neo-Nazi groups (dislikable) and half of which did not (likable). All subjects and actors in the stimuli were Caucasian and physically similar. The subjects then viewed videos of actors portraying the characters performing simple motor actions (e.g. grasping a water bottle and raising it to the lips), while undergoing fMRI. Using multivariate pattern analysis (MVPA), we found that a classifier trained on brain activation patterns successfully discriminated between the likable and dislikable action observation conditions within the right ventral premotor cortex. These data indicate that the spatial pattern of activity in action observation related neural regions is modulated by likability even when watching a simple action such as reaching for a cup. These findings lend further support for the notion that social factors such as interpersonal liking modulate perceptual processing in motorrelated cortices.

Brief periods of unconscious thought (UT) have been shown to improve decision making compared with making an immediate decision (ID). We reveal a neural mechanism for UT in decision making using blood oxygen level-dependent (BOLD) functional magnetic resonance imaging. Participants (N ¼ 33) encoded information on a set of consumer products (e.g. 48 attributes describing four different cars), and we manipulated whether participants (i) consciously thought about this information (conscious thought), (ii) completed a difficult 2-back working memory task (UT) or (iii) made an immediate decision about the consumer products (ID) in a within-subjects blocked design. To differentiate UT neural activity from 2-back working memory neural activity, participants completed an independent 2-back task and this neural activity was subtracted from neural activity occurring during the UT 2-back task. Consistent with a neural reactivation account, we found that the same regions activated during the encoding of complex decision information (right dorsolateral prefrontal cortex and left intermediate visual cortex) continued to be activated during a subsequent 2-min UT period. Moreover, neural reactivation in these regions was predictive of subsequent behavioral decision-making performance after the UT period. These results provide initial evidence for post-encoding unconscious neural reactivation in facilitating decision making.

Brief periods of unconscious thought (UT) have been shown to improve decision making compared with making an immediate decision (ID). We reveal a neural mechanism for UT in decision making using blood oxygen level-dependent (BOLD) functional magnetic resonance imaging. Participants (N ¼ 33) encoded information on a set of consumer products (e.g. 48 attributes describing four different cars), and we manipulated whether participants (i) consciously thought about this information (conscious thought), (ii) completed a difficult 2-back working memory task (UT) or (iii) made an immediate decision about the consumer products (ID) in a within-subjects blocked design. To differentiate UT neural activity from 2-back working memory neural activity, participants completed an independent 2-back task and this neural activity was subtracted from neural activity occurring during the UT 2-back task. Consistent with a neural reactivation account, we found that the same regions activated during the encoding of complex decision information (right dorsolateral prefrontal cortex and left intermediate visual cortex) continued to be activated during a subsequent 2-min UT period. Moreover, neural reactivation in these regions was predictive of subsequent behavioral decision-making performance after the UT period. These results provide initial evidence for post-encoding unconscious neural reactivation in facilitating decision making.

Neuroimaging investigations of self-processing have generally focused on the neural correlates of explicit self-reflection. However, very little is known about the neural basis of implicit self-related processes. We utilized the concept of self-schemas to construct a two-task fMRI study that elicited both implicit and explicit self-relevant processes. The sample consisted of 18 participants who were schematic for either athletics or science. In the implicit self-relevance task, individuals made non-self-relevant judgments about affectively neutral scientific and athletic images. In the explicit self-reference task, participants judged the selfdescriptiveness of adjectives related to athletics or science. Implicit and explicit processing of self-relevant (schematic) material elicited activity in many of the same regions, including medial prefrontal cortex, posterior cingulate/precuneus, ventromedial prefrontal cortex, subgenual anterior cingulate, amygdala, and ventral striatum. We suggest that processing self-related material recruits similar neural networks regardless of whether the self-relevance is made explicit or not.

The experience of reality (EoR, sometimes also known as subjective veridicality) is a relevant part of our everyday conscious experience. EoR holds the potential to shape reasoning, reporting, and acting. EoR helps us navigate goals, but it also can be an instrument for social control and manipulation, and may contribute to explaining phenomena such as gaslighting, epistemic stubbornness, or fake news dissemination. EoR has also profound implications in philosophical issues, such as the delimitation of the concept of reality. Here, I analyze the EoR from a process-based perspective, without avoiding its phenomenology. I propose a distinction between three types of EoR: EoR out there, EoR of the experience itself and EoR somehow. (EoR somehow is a kind of experience of just reality, with no related content, sometimes called pure consciousness event, and not to be confused with the Cartesian cogito.) I also put forward two key ideas concerning EoR. First, I argue that EoR is not always aligned with reality. In other words, the content we experience as real does not always correspond to what is really the case. Therefore, even though misalignment can be reduced through a diverse range of dynamics, the succession of the processes of acquisition of sense data, alignment dynamics, objective veridicality, and subjective veridicality is not a one-way, transitive, straightforward pathway. So, EoR entails more construction and requires more caution than expected a priori. Second, I identify a rare but significant exception to this rule: EoR somehow. Since EoR somehow lacks content, it admits no misalignment. The existence of such a kind of experience suggests that the processes that underpin EoR are specific, interacting but not fully dependent on content.

Perceptually categorizing a face to its racial belonging may have important consequences on interacting with people. However, race categorical perception (CP) has been scarcely investigated nor its developmental pathway. In this study, we tested the neurolinguistics rewiring hypothesis, stating that language acquisition modulates the brain processing of social perceptual categories. Accordingly, we investigated the electrophysiological correlates of race CP in a group of adults and children between 3 and 5 years of age. For both groups we found a greater modulation of the N400 connected with the processing of between category boundaries (i.e., faces belonging to different race groups) than withincategory boundaries (i.e., different faces belonging to the same race group). This effect was the same in both adults and children, as shown by the comparable between-group amplitude of the differential wave (DW) elicited by the between-category faces. Remarkably, this effect was positively correlated with racial-labels acquisition, but not with age, in children. Finally, brain source analysis revealed the activation of a more modularized cortical network in adults than in children, with unique activation of the left superior temporal gyrus (STG) and the inferior frontal gyrus (IFG), which are areas connected to language processing. These are the first results accounting for an effect of language in rewiring brain connectedness when processing racial categories.

How consciousness (experience) arises from and relates to material brain processes (the “mind-body problem”) has been pondered by thinkers for centuries, and is regarded as among the deepest unsolved problems in science, with wide-ranging theoretical, clinical, and ethical implications. Until the last few decades, this was largely seen as a philosophical topic, but not widely accepted in mainstream neuroscience. Since the 1980s, however, novel methods and theoretical advances have yielded remarkable results, opening up the field for scientific and clinical progress. Since a seminal paper by Crick and Koch (1998) claimed that a science of consciousness should first search for its neural correlates (NCC), a variety of correlates have been suggested, including both content-specific NCCs, determining particular phenomenal components within an experience, and the full NCC, the neural substrates supporting entire conscious experiences. In this review, we present recent progress on theoret...

How consciousness (experience) arises from and relates to material brain processes (the "mind-body problem") has been pondered by thinkers for centuries, and is regarded as among the deepest unsolved problems in science, with wide-ranging theoretical, clinical, and ethical implications. Until the last few decades, this was largely seen as a philosophical topic, but not widely accepted in mainstream neuroscience. Since the 1980s, however, novel methods and theoretical advances have yielded remarkable results, opening up the field for scientific and clinical progress. Since a seminal paper by Crick and Koch (1998) claimed that a science of consciousness should first search for its neural correlates (NCC), a variety of correlates have been suggested, including both content-specific NCCs, determining particular phenomenal components within an experience, and the full NCC, the neural substrates supporting entire conscious experiences. In this review, we present recent progress on theoretical, experimental, and clinical issues. Specifically, we (1) review methodological advances that are important for dissociating conscious experience from related enabling and executive functions, (2) suggest how critically reconsidering the role of the frontal cortex may further delineate NCCs, (3) advocate the need for general, objective, brain-based measures of the capacity for consciousness that are independent of sensory processing and executive functions, and (4) show how animal studies can reveal population and network phenomena of relevance for understanding mechanisms of consciousness.

Background: Patients with Alzheimer's disease (AD) exhibit an impaired serial position effect (SPE) during free recall, whereby fewer initial list items (primacy region) are recalled than end-of-list items (recency region), generating a 'primacy effect'. We performed a voxel-based morphometric study with healthy and dementia patients to determine the behavioral and neural correlates of the SPE. Methods: 62 controls and 69 patients with AD, mild cognitive impairment and other dementias participated. Behavioral measures: All participants received (a) the California Verbal Learning Test, where percent recall scores were calculated for primacy, middle and recency regions (Tri-als1-5), and (b) Digits Forward, Digits Backward and Animal fluency to estimate, respectively, phonological loop, working memory, and semantic memory. Voxel Based Morphometry: 3D T1-weighted images were acquired. Preprocessing and volumetric analyses were conducted with modulated gray matter images using the DARTEL procedure in SPM8 in Matlab. Results: Behavior: Groups differed on overall learning performance (F(1,129) ¼ 130.4; p < .001). Patients showed the primacy effect (F(1,68) ¼ 13.32; p < .001), and primacy performance was associated with fluency (r ¼ + 401, p < .001) but not attentional performance. Controls showed greater primacy recall than patients (Tukey, p < .001) which correlated with more digits backward (r ¼ +.304, p ¼.02) and a trend for better fluency performance (r ¼ +.217, p ¼.09). Better recency recall correlated with digits forward only for controls (r ¼ +.252, p < .01). VBM: Over both groups, primacy recall significantly correlated with right middle occipital lobe and angular gyrus regions, including Brodmann's Area 40, and left middle and medial temporal lobes including the hippocampus. Recency recall was associated with grey matter loss in bilateral parahippocampal cortices, hippocampi, superior temporal gyri and temporal poles. Conclusions: Recency recall was associated with low-level attentional processing and bilateral temporal lobe integrity. Primacy recall was associated with working and semantic memory for controls but only with semantic memory performance in patients, and with temporal and parietal lobe integrity over both groups. These results suggest that higher level attentional skills are required to learn and retain primacy items, which patients lack. Since the parieto-temporal network underpinning the primacy effect is affected early in the course of AD, this measure may serve as a powerful cognitive-biomarker of this disease.

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by deficits in cognitive and emotional self-control. Optical technique acquisitions, such as near infrared spectroscopy (NIRS), seem to be very promising during developmental ages, as they are non-invasive techniques and less influenced by body movements than other neuroimaging methods. Recently, these new techniques are being widely used to measure neural correlates underlying neuropsychological deficits in children with ADHD. In a short series of articles, we will review the results of functional NIRS (fNIRS) studies in children with ADHD. The present brief review will focus on the results of the fNIRS studies that investigate cortical activity during neuropsychological and/or emotional tasks. According to the reviewed studies, children and adolescents with ADHD show peculiar cortical activation both during neurological and emotional tasks, and the majority of the reviewed studies revealed lower prefrontal cortex activation in patients compared to typically developmental controls. Limitations: a consistent interpretation of these results is limited by the substantial methodological heterogeneity including patients' medication status and washout period, explored cerebral regions, neuropsychological tasks, number of channels and sampling temporal resolutions.

Restoring function to damaged neural pathways, or promoting compensatory strategies to overcome dysfunctional neural pathways have been topics of inquiry within motor rehabilitation. This study considers these topics in Parkinsons disease (PD), where disruption within the striatal-thalamic-cortical (STC) circuits can cause impairment in internally guided (IG) movements. A related, but separate externally guided (EG) movement network, recruits the intact cerebellar-thalamic-cortical (CTC) loop to facilitate movement in response to sensory cues, and is effective in remediating motor function. Partnered dance with leading and following roles may be used as proxies for training IG and EG strategies respectively, in PD and can test which strategy is more effective in remediating effects of PD. Leaders determine variables associated with IG and communicate step amplitude, timing, and direction to the follower. Followers use an EG strategy to sense and interpret directional pressure cues f...

Autobiographical memories enable us to mentally reconstruct and relive past events, which is essential for one's personal identity. Unfortunately, this complex memory system is susceptible to age-related deterioration, possibly changing the way episodic information is being processed in older adults. The aim of this study was to investigate whether age influences the neural activity associated with content (episodic versus semantic) and remoteness (recent versus remote) of memories. Using functional magnetic resonance imaging in healthy older and young adults, we found significant age-dependent differences in the neural networks underlying memory content but not remoteness. Our data suggest an age-associated functional reorganization in the neural networks underlying long-term declarative memory. Relative increase in activity of posterior brain regions could reflect changes in visuospatial processing during episodic memory retrieval in older adults.

Autobiographical memories enable us to mentally reconstruct and relive past events, which is essential for one's personal identity. Unfortunately, this complex memory system is susceptible to age-related deterioration, possibly changing the way episodic information is being processed in older adults. The aim of this study was to investigate whether age influences the neural activity associated with content (episodic versus semantic) and remoteness (recent versus remote) of memories. Using functional magnetic resonance imaging in healthy older and young adults, we found significant age-dependent differences in the neural networks underlying memory content but not remoteness. Our data suggest an age-associated functional reorganization in the neural networks underlying long-term declarative memory. Relative increase in activity of posterior brain regions could reflect changes in visuospatial processing during episodic memory retrieval in older adults.

Despite this body of work, the relative contributions of these areas to guiding spatial selection and visuomotor behavior are still poorly understood. This is due mainly to the limitations of traditional imaging methods. In particular, while microelectrode recordings shed light on the specialized functions of highly localized cortical regions, they typically do not capture activity across spatially distributed networks simultaneously. Thus, they cannot characterize activity in distributed networks or their interactions. fMRI, on the other hand, cannot capture the dynamics of attentional mechanisms with high temporal resolution. This limitation is due in part to technical factors (e.g., scanning durations), but

Stress engages multiple neurobiological modifications and a failure to regulate these may lead to chronic psychiatric problems. Despite considerable research, it remains unclear how neural alterations of acute stress reflect the ability to cope with chronic stress. The current longitudinal study examined the whole-brain network dynamics following induced acute stress and its prediction of vulnerability to real-life chronic stress. 60 military pre-deployment soldiers (all male) underwent a lab-induced stress task during which resting fMRI was acquired before stress, after stress, and at recovery (90 minutes later). Subjective stress was repeatedly measured during the experiment. Depression and post-traumatic stress symptoms were also evaluated, as well as a year later during military deployment. A time-varying analysis was applied to characterize the dominant activity of different states as they change over time. Findings reveal that, from acute stress to recovery, the frontoparietal...

Nobody knows exactly how consciousness is produced. To make matters worse, nobody even knows what consciousness is. In this article, I provide insight into what consciousness is, and how it is produced, by showing that consciousness is faster than light. I also show that consciousness is a new faster-than-light phenomenon; as opposed to coming from non-local quantum mechanics. To be clear, I have not disproven Einstein's theory of relativity; instead, I have discovered a loophole in Einstein's theory of relativity that applies to consciousness. The discovery that consciousness is faster than light is important, because it shows that consciousness cannot be a particle, energy, or anything else located in space (e.g. not a soul). In other words, we can now conclude that consciousness is non-energy information. Where does this non-energy information (i.e. consciousness) come from? The discovery that consciousness is faster than light excludes numerous theories of consciousness while also enabling new theories of consciousness. For example, a computational theory of consciousness was previously untenable due to the fact that there is no convergence point in the brain for all information and the speed limit of light prevented the conscious observer from accessing all of the distributed information in the brain, but now a computational theory of consciousness is plausible. I show rare case reports and evidence that support the theory that consciousness (i.e. non-energy information) is, at least in part, produced directly from "non-trivial" computations.

Using a concurrent ERP/fMRI paradigm, we investigated how listeners take advantage of morphologically relevant tonal information at the beginning of words to predict and pre-activate likely word endings. More predictive, low tone word stems gave rise to a 'pre-activation negativity' (PrAN) in the ERPs, a brain potential which has previously been found to increase along with the degree of predictive certainty as regards how a word is going to end. It is suggested that more predictive, low tone stems lead to rapid access to word endings with processing subserved by the left primary auditory cortex as well as the supramarginal gyrus, while high tone stemswhich are less predictivedecrease predictive certainty, leading to increased competition between activated word endings, which needs to be resolved by the left inferior frontal gyrus.

To date, little is known about the neural mechanisms underlying overt visual search. In two experiments, we concurrently recorded EEG and eye movements while participants searched for two identical targets amongst a set of distractors. In such a multiple-target paradigm, participants must continue the search after finding the first target and memorize its location. We investigated neural correlates of item processing in different stages of the search using fixation-related potentials (FRPs). Results of Experiment 1 showed that the detection of the first target elicited a P3-like component absent in distractor fixations. Furthermore, finding the first target influenced FRPs in continued search: a sustained negativity was observed for distractor fixations following the first target fixation, likely indicating the involvement of memory. In Experiment 2, display size was manipulated systematically (10, 22, 30 items). Eye movement analysis showed that the average number of fixations preceding the first target detection varied as a function of display size. We present FRPs for target fixations and discuss the influence of the number of preceding distractor fixations on their morphology. In addition, we analyzed the post-target negativity over longer time intervals and report on its temporal properties and functional role.

In visual backward masking (VBM), a target is followed by a mask that decreases target discriminability. Schizophrenia patients (SZ) show strong and reproducible masking impairments, which are associated with reduced EEG amplitudes. Patients with bipolar disorder (BP) show masking deficits, too. Here, we investigated the neural EEG correlates of VBM in BP. 122 SZ, 94 unaffected controls, and 38 BP joined a standard VBM experiment. 123 SZ, 94 unaffected controls and 16 BP joined a corresponding EEG experiment, analyzed in terms of global field power. As in previous studies, SZ and BP show strong masking deficits. Importantly and similarly to SZ, BP show decreased global field power amplitudes at approximately 200 ms after the target onset, compared to controls. These results suggest that VBM deficits are not specific for schizophrenia but for a broader range of functional psychoses. Potentially, both SZ and BP show deficient target enhancement.

Visual backward masking (VBM) deficits are candidate endophenotypes of schizophrenia indexing genetic liability of the disorder. In VBM, a target is followed by a mask that deteriorates target perception. Schizophrenia patients and, to a lesser extent, their unaffected relatives show strong and reproducible VBM deficits. In patients, VBM deficits are associated with strongly decreased amplitudes in the evoked-related potentials (ERPs). Here, to unveil the neural mechanisms of VBM in schizophrenia, circumventing illness-specific confounds, we investigated the electroencephalogram correlates of VBM in unaffected siblings of schizophrenia patients. We tested 110 schizophrenia patients, 60 siblings, and 83 healthy controls. As in previous studies, patients showed strong behavioral deficits and decreased ERP amplitudes compared to controls. Surprisingly, the ERP amplitudes of siblings were even higher than the ones of controls, while their performances were similar. ERP amplitudes in siblings were found to correlate with performance. These results suggest that VBM is deteriorated in patients and siblings. However, siblings, unlike patients, can partially compensate for the deficits by over-activating a network of brain regions.

Recent neuroimaging studies have investigated the neural substrates involved in the valuation of supraliminally presented targets and the subsequent preference decisions. However, the neural mechanisms of the valuation of subliminally presented targets, which can guide subsequent preference decisions, remain to be explored. In the present study, we determined whether the neural systems associated with the valuation of supraliminally presented faces are involved in the valuation of subliminally presented faces. The subjects were supraliminally and subliminally presented with faces during functional magnetic resonance imaging (fMRI). Following fMRI, the subjects were presented with pairs of faces and were asked to choose which face they preferred. We analyzed brain activation by back-sorting the fMRI data according to the subjects&#39; choices. The present study yielded two main findings. First, the ventral striatum and the ventromedial prefrontal cortex predict preferences only for s...

Sepede G, De Berardis D, Campanella D, Perrucci MG, Ferretti A, Serroni N, Moschetta FS, Del Gratta C, Salerno RM, Ferro FM, Di Giannantonio M, Onofrj M, Romani GL, Gambi F. Impaired sustained attention in euthymic bipolar disorder patients and non‐affected relatives: an fMRI study. Bipolar Disord 2012: 14: 764–779. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S.Objective:  Behavioral deficits in sustained attention have been reported during both acute and euthymic phases of type I bipolar disorder (BD‐I) and also in non‐affected relatives of bipolar disorder (BD) patients. In particular, selective failure in target recognition was proposed as a potential trait marker for BD, but there are few studies exploring the neural correlates. The aim of the present study was to analyze the behavioral and functional magnetic resonance imaging (fMRI) response of euthymic BD‐I patients and non‐affected relatives during a sustained attention task.Methods:  Twenty‐four euthy...

With increasing age, people experience more difficulties with suppressing irrelevant information, which may have a major impact on cognitive functioning. The extent of decline of inhibitory functions with age is highly variable between individuals. In this study, we used ERPs and phase locking analyses to investigate neural correlates of this variability in inhibition between individuals. Older and younger participants performed a selective attention task in which relevant and irrelevant information was presented simultaneously. The participants were split into high and low performers based on their level of inhibition inefficiency, that is, the slowing of RTs induced by information that participants were instructed to ignore. P1 peak amplitudes were larger in low performers than in high performers, indicating that low performers were less able to suppress the processing of irrelevant stimuli. Phase locking analyses were used as a measure of functional connectivity. Efficient inhibi...

This research investigates the neural correlates of consciousness (NCC) through a novel “no-cognition” paradigm that employs the unique capacity of meditators to prevent cognitive reactions to stimuli. It also uses the innovative ability of machine learning to decode perceptual content from brain activity to test a prediction about the temporal dynamics of consciousness. 

Within neuroscience, the exact parameters of NCC is a matter of contention. For cognitively based theories, the NCC entails activity related to cognition in the frontal cortex in addition to perceptually related  processing in the occipital and temporal cortex. This is opposed to sensory-based theories that mainly focus on the occipital and temporal cortex. 

Using electroencephalography, the experiment tested the neural responses of a group of advanced meditators and non-meditative controls. A comparison of the groups across no-task and task conditions evaluated whether the P3b component is an NCC, as predicted by the
cognitively based global neuronal workspace theory (GNWT), or constitutes a neural correlate of cognitive processing related to task relevance. We also tested GNWT’s prediction that consciousness arises 300–600 ms post stimulus. 

Our results appear to provide evidence that the P3b component is not an NCC, but is instead a neural correlate of cognitive processing related to task relevance, as demonstrated by the P3b’s presence in the task condition and disappearance in the no-task condition. For decoding, we found that accuracy remained above chance until 500 ms in both conditions when comparing between stimulus categories and individual face stimuli, which is consistent with GNWT’s temporal predictions about consciousness’s ignition. Overall, this data implies that some facets of the competing theories are valid, while other aspects are invalid, thus suggesting that cognitivist and sensory based theories should be integrated, instead of entirely opposed to one another.

The relationship between neural social cognition patterns and performance on social cognition tasks in daily life is a topic of debate, with key consideration given to the extent to which theory of mind (ToM) brain circuits share properties re ecting the naturalistic context. To test implicit and explicit mentalizing in naturalistic context, we used an experimental fMRI paradigm that provided brain activation within the ToM brain circuits. We conducted the experiment on 42 adults and found that only explicit mentalizing, which involved silent viewing and two-choice answers, elicited activation of ToM neural circuits when animations of everyday social interactions were presented. We also observed that the nature of ToM reasoning, i.e., affective or cognitive, played a signi cant role in activating different neural circuits. By considering the condition (implicit vs explicit) and nature (affective vs cognitive) of social interactions in naturalistic context, we can understand the similarities and differences across ToM brain circuits during social interactions.

Despite ample support for enhanced affective well-being and emotional stability in healthy aging, the role of potentially important dimensions, such as the emotional arousal, has not been systematically investigated in neuroimaging studies. In addition, the few behavioral studies that examined effects of arousal have produced inconsistent findings. The present study manipulated the arousal of pictorial stimuli to test the hypothesis that preserved emotional functioning in aging is modulated by the level of arousal, and to identify the associated neural correlates. Young and older healthy participants were presented with negative and neutral pictures, which they rated for emotional content, while fMRI data were recorded. There were three main novel findings regarding the neural mechanisms underlying the processing of negative pictures with different levels of arousal in young and older adults. First, the common engagement of the right amygdala in young and older adults was driven by high arousing negative stimuli. Second, complementing an age-related reduction in the subjective ratings for low arousing negative pictures, there were opposing patterns of activity in the rostral/ventral anterior cingulate cortex (ACC) and the amygdala, which showed increased vs. decreased responses, respectively, to low arousing negative pictures. Third, increased spontaneous activity in the ventral ACC/ventromedial prefrontal cortex (vmPFC) in older adults was linked to reduced ratings for low arousing negative pictures. Overall, these findings advance our understanding of the neural correlates underlying processing of negative emotions with different levels of arousal in the context of enhanced emotional functioning in healthy aging. Notably, the results support the idea that older adults have emotion regulation networks chronically activated, in the absence of explicit induction of the goal to regulate emotions, and that this effect is specific to low arousing negative emotions.

Recollection of emotional autobiographical memories (AMs) is important to healthy cognitive and affective functioning 1 -remembering positive AMs is associated with increased personal well-being and self-esteem 2 , whereas remembering and ruminating on negative AMs may lead to affective disorders 3 . Although significant progress has been made in understanding the brain mechanisms underlying AM retrieval in general (reviewed in 4, 5 ), less is known about the effect of emotion on the subjective re-experience of AMs and the associated neural correlates. This is in part due to the fact that, unlike the investigations of the emotion effect on memory for laboratory-based microevents (reviewed in 6, 7-9 ), often times AM studies do not have a clear focus on the emotional aspects of remembering personal events (but see 10 ). Here, we present a protocol that allows investigation of the neural correlates of recollecting emotional AMs using functional magnetic resonance imaging (fMRI). Cues for these memories are collected prior to scanning by means of an autobiographical memory questionnaire (AMQ), therefore allowing for proper selection of emotional AMs based on their phenomenological properties (i.e., intensity, vividness, personal significance). This protocol can be used in healthy and clinical populations alike.

Due to their ability to capture attention, emotional stimuli tend to benefit from enhanced perceptual processing, which can be helpful when such stimuli are task-relevant but hindering when they are task-irrelevant. Altered emotion-attention interactions have been associated with symptoms of affective disturbances, and emerging research focuses on improving emotion-attention interactions to prevent or treat affective disorders. In line with the Human Affectome Project's emphasis on linguistic components, we also analyzed the language used to describe attention-related aspects of emotion, and highlighted terms related to domains such as conscious awareness, motivational effects of attention, social attention, and emotion regulation. These terms were discussed within a broader review of available evidence regarding the neural correlates of (1) Emotion-Attention Interactions in Perception, (2) Emotion-Attention Interactions in Learning and Memory, (3) Individual Differences in and (4) Training and Interventions to Optimize Emotion-Attention Interactions. This comprehensive approach enabled an integrative overview of the current knowledge regarding the mechanisms of emotion-attention interactions at multiple levels of analysis, and identification of emerging directions for future investigations.

Available evidence suggests that emotion regulation can modulate both immediate (emotional experience) and long-term (episodic memory) effects of emotion, and that both explicit and implicit forms may be effective. However, neural mechanisms by which explicit and implicit emotional suppression affect these phenomena remain unclear, particularly regarding their effects on memory. In this study, participants rated the emotional content of negative and neutral images, following explicit (verbal instructions) or implicit (priming) induction of emotional suppression goals, during functional magnetic resonance imaging. Participants&#39; memory for the images was tested one week later. Behaviorally, explicit suppression reduced emotional ratings of negative images, whereas both explicit and implicit suppression reduced subsequent memory. At the neural level, the engagement of explicit suppression was uniquely associated with decreased activity in the amygdala (AMY), during emotional rating...

Despite ample support for enhanced affective well-being and emotional stability in healthy aging, the role of potentially important dimensions, such as the emotional arousal, has not been systematically investigated in neuroimaging studies. In addition, the few behavioral studies that examined effects of arousal have produced inconsistent findings. The present study manipulated the arousal of pictorial stimuli to test the hypothesis that preserved emotional functioning in aging is modulated by the level of arousal, and to identify the associated neural correlates. Young and older healthy participants were presented with negative and neutral pictures, which they rated for emotional content, while fMRI data were recorded. There were three main novel findings regarding the neural mechanisms underlying the processing of negative pictures with different levels of arousal in young and older adults. First, the common engagement of the right amygdala in young and older adults was driven by ...

Remembering emotional autobiographical memories (AMs) is important for emotional well-being, and investigation of the role of emotion regulation (ER) during AM recollection has relevance for understanding mental health issues. Although significant progress has been made in understanding the brain mechanisms underlying ER and AM, less is known about the role of ER during AM recollection. The present study investigated how focusing away (or distracting) from the emotional content during AM recollection influences the subjective re-experiencing of emotions and the associated neural correlates, by manipulating the retrieval focus of participants who remembered emotional AMs while fMRI data were recorded. First, focusing away from emotion led to decreased self-reported emotional responses, along with increased engagement of ER-related regions (ventro-medial prefrontal cortex, vmPFC), and reduced activity in emotion-related regions (amygdala, AMY). Second, increased vmPFC activity was linked to reduced emotional ratings, during the non-emotional focus. Third, mediation analysis identified vmPFC as a functional hub integrating affective signals from AMY and mediating their impact on the subjective re-experiencing of emotion, according to the current retrieval focus. Collectively, these findings shed light on the neural mechanisms underlying the ability to effectively switch attentional focus away from emotions during AM recollections and have direct relevance for understanding, preventing and treating affective disorders, characterised by reduced ability to regulate emotions.

We present a protocol that allows investigation of the neural mechanisms mediating the detrimental impact of emotion on cognition, using functional magnetic resonance imaging. This protocol can be used with both healthy and clinical participants.

The ability to gauge social interactions is crucial in the assessment of others' intentions. Factors such as facial expressions and body language affect our decisions in personal and professional life alike 1 . These "friend or foe" judgements are often based on first impressions, which in turn may affect our decisions to "approach or avoid". Previous studies investigating the neural correlates of social cognition tended to use static facial stimuli 2 . Here, we illustrate an experimental design in which whole-body animated characters were used in conjunction with functional magnetic resonance imaging (fMRI) recordings. Fifteen participants were presented with short movie-clips of guest-host interactions in a business setting, while fMRI data were recorded; at the end of each movie, participants also provided ratings of the host behaviour. This design mimics more closely real-life situations, and hence may contribute to better understanding of the neural mechanisms of social interactions in healthy behaviour, and to gaining insight into possible causes of deficits in social behaviour in such clinical conditions as social anxiety and autism 3 .

What are the neural markers of encoding and retrieving emotional events with increased efficacy? In recent years, this question has captured the attention of cognitive neuroscientists who fervently engaged in addressing it using a multitude of approaches. The present review discusses evidence from brain imaging studies investigating the neural correlates of the memory-enhancing effect of emotion in healthy human participants. The available evidence points to two main mechanisms: one direct involving the medial temporal lobe (MTL), and the other indirect involving the prefrontal cortex (PFC), among other brain regions. Recent studies also showed that these mechanisms are sensitive to aspects relevant to social interactions, as well as to personality-, sex-and age-related differences. Overall, this evidence provides insights into the brain mechanisms that make emotional memories special, and points to possible alterations that could lead to negative affective biases in encoding and remembering emotional memories observed in affective disorders.

A central observation in the recognition memory literature is that neural processes occurring during encoding of stimuli are predictive of their later recognition and recall. Compared to items that are later forgotten, encoding of correctly recognised items has been associated with greater amplitude between 400 ms and 800 ms post stimulus onset across centro-parietal sites (the difference-due-to-memory ERP effect), increased EEG power in the theta and gamma frequency bands and decreased EEG power in the alpha and beta bands, and increased theta-gamma phase-amplitude coupling. Importantly, theories of encoding based on these findings imply that these effects should be domain-general. In this pre-registered study, we tested this assumption by exploring neural correlates of successful encoding in learning of novel names for novel concepts. Following the previous studies, we used three different measures of neural activity, ERPs, time-frequency representations of power, and phase-amplitude coupling; however, for either of these measures, we could not reject the null hypothesis of no difference between the novel names that were later recalled and those that were not. We provide three possible interpretations of our findings, and our main conclusion is that the existing theories of encoding may be underspecified and that properly-powered pre-registered studies are needed to further constrain these theories.

A central observation in the recognition memory literature is that neural processes occurring during encoding of stimuli are predictive of their later recognition. Compared to items that are later forgotten, encoding of correctly recognised items has been associated with greater amplitude between 400 ms and 800 ms post stimulus onset across centro-parietal sites (the difference-due-to-memory ERP effect), increased EEG power in the theta and gamma frequency bands and decreased EEG power in the alpha and beta bands, and increased theta-gamma phase-amplitude coupling. Importantly, theories of encoding based on these findings imply that these effects should be domain-general. In this pre-registered study, we tested this assumption by exploring neural correlates of successful encoding in learning of novel names for novel concepts. Following the previous studies, we used three different measures of neural activity, ERPs, time-frequency representations of power, and phase-amplitude couplin...