Longitudinal Study

Compares conceptualizations of homelessness as a temporary state through which people pass or a permanent trait that emanates from individual characteristics. Evidence from a longitudinal study of 564 homeless families in New York City and additional secondary sources supports the view that for families, homelessness is a temporary state that is resolved by the provision of subsidized housing. Even for single individuals with severe mental disturbances, housing is a key factor in ending homelessness, although here there is more evidence that social services also contribute. Policy implications are that governments should take a more active role in reducing homelessness by providing access to subsidized housing.

Background  Extremely low and very low gestational age (ELGA and VLGA) constitutes a risk factor for development even in absence of cerebral damage, as an immature central nervous system is exposed to invasive and inadequate stimulation. We tested the hypothesis that GA impacts developmental outcomes and trajectories of preterms without major cerebral damage in the first 2 years of life, expecting poorer developmental outcomes and higher rate of impairment with the decreasing of GA. We also evaluated whether GA, together with developmental outcomes in the first year of life, was related to developmental outcomes at 24 months.Methods  Eighty-eight infants, divided into three GA groups (ELGA: ≤28 weeks; VLGA: 29–32 weeks; full term: >37 weeks) were assessed longitudinally at 6, 12, 18 and 24 months using the Griffiths Mental Development Scales.Results  Use of a repeated measure multivariate analysis of variance resulted in several significant findings. GA was associated with the developmental quotient (DQ) scores (P= 0.006); and locomotor (P < 0.001), eye and hand co-ordination (P= 0.016) and performance (P= 0.040) sub-scale quotient (SQ) scores; age of evaluation was also associated with DQ scores (P= 0.002), and locomotor (P < 0.001) and performance (P < 0.001) SQ scores. In particular, ELGAs exhibited lower DQ and SQ scores compared with the VLGA and full-term groups; some ELGAs showed mild, moderate or severe cognitive impairments, while few VLGAs mild impairments. Linear regression analysis showed that GA (P= 0.034) and 12-month developmental outcome (P < 0.001) were related to 24-month developmental outcome.Conclusions  Different developmental trajectories emerged in relation to GA, with poorer developmental outcomes and higher rates of impairment in ELGAs and few mild impairments in VLGAs. The relevance of taking into account both GA and repeated assessments in the first 2 years of life was shown.

Using a sample of dental students (N=373) from four Canadian dental schools, this longitudinal study determined whether the new Canadian Dental Association (CDA) structured interview was a predictor of clinical and academic performance. The new interview predicted clinical performance in the third and fourth years of dental school, but not academic performance. The Canadian Dental Aptitude Test (DAT) continued to predict first- and second-year academic performance, but not clinical performance in the senior years. A personality factor, &quot;Conscientiousness,&quot; predicted clinical and academic performance to various degrees across the four years of dental school. A second personality factor, &quot;Openness to Experience,&quot; predicted third-year academic performance. The results suggest that a combination of scores from the DAT, a valid measure of personality, and a well-designed structured interview will provide the best prediction of those applicants who will do well in both...

This longitudinal research aimed to determine the utility of psychosocial and eating characteristics in early teenage years in predicting eating attitudes and behaviors in early adulthood. Self-esteem, perfectionism, family function, and eating attitudes were measured at 12 years and eating attitudes and behavior were assessed at 19 years. Sixty-three women (71.6%) remained in the study over the 7 years. Bulimic attitudes in early teenage years were related to subsequent bulimic features, while restrictive attitudes were more closely related to later purging behaviors. Self-esteem and perfectionism were only weakly linked with subsequent eating. However, different perceived family characteristics at the first stage were associated with specific aspects of eating in early adulthood. There is consistency of eating characteristics across time, but psychosocial characteristics have a more limited predictive power. Future longitudinal studies should begin earlier in childhood if psychoso...

The current study is a longitudinal investigation of unobserved heterogeneity in the developmental trajectories of problem behaviors among children who have experienced maltreatment. The goal of this study is to inform effective intervention plans with respect to behavior problems of maltreated children by examining the different trajectories of behavior problems and by assessing ecological risk factors related to each trajectory. This study utilized data from the Longitudinal Study of Child Abuse and Neglect, in which 827 maltreated children have been followed from age 4 to age 10. This study identified five distinctive developmental trajectories of maltreated children. In most trajectory groups, a specific set of ecological risk factors distinctively predicted the probability of membership in a specific group. The results are discussed with respect to individualized early intervention efforts toward those most likely to benefit.

In the US, it is currently estimated that 3% of pregnant women have chronic hypertension, or more than 100,000 pregnant women each year. The aim of our study was to investigate the adaptation of autonomic control during pregnancy based on heart rate variability analysis and to determine whether chronic hypertension during pregnancy has an impact on this adaptation. Sixteen pregnant women with chronic hypertension (CH group; mean age, 30 years; range, 25-33 years) and 35 healthy pregnant women serving as controls (CON group; mean age, 28 years; range, 24-30 years) were recruited for this longitudinal study. Beginning at the 20th week of pregnancy, the women were monitored every 4th week until delivery. For the analysis of heart rate variability, Portapres signals (200 Hz) were recorded for 30 min under resting conditions. Women in the CH group had significantly elevated blood pressure compared to controls (CON, 111 mmHg [105-132]; CH, 140 mmHg [132-148]; p <0.001). An increased heart rate was found in both groups during the second half of pregnancy. Consequently, decreased heart rate variability was observed, but was more pronounced in the CON group. There was a shift in the frequency bands indicated by an elevation of the low-to-high frequency ratio (LF/HF) in both groups due to a decrease in HF, and thus a significant increase in LFn (LF power in normalized units). However, VLF (power of very low frequency range) increased exclusively in the CON pregnancies. Our data showed no significant difference in heart rate variability between the subjects of the CH and CON groups. Longitudinal variations were detectable in normal pregnancies and also, albeit to a lesser degree, in chronic hypertensive pregnant women. Thus, our data indicate that patients with long-term hypertension are still able to respond to the physiological changes occurring during pregnancy.

Low back pain (LBP) in children and adolescents was considered for many years to be rare and an indication of serious disease [1]. In the last two decades, epidemi-ological studies have shown that the prevalence of ... Ismail Bejia Nabiha Abid Kamel Ben Salem Mondher Letaief ...

The National Longitudinal Study of Adolescent Health data were used to test predictions from life history theory. We hypothesized that (1) in young adulthood an emerging life history strategy would exist as a common factor underlying many life history traits (e.g., health, relationship stability, economic success), (2) both environmental harshness and unpredictability would account for unique variance in expression of adolescent and young adult life history strategies, and (3) adolescent life history traits would predict young adult life history strategy. These predictions were supported. The current findings suggest that the environmental parameters of harshness and unpredictability have concurrent effects on life history development in adolescence, as well as longitudinal effects into young adulthood. In addition, life history traits appear to be stable across developmental time from adolescence into young adulthood.

Background and Objectives: Prior research suggests that parents' monitoring behaviors are related to the conduct problems of children but not to the conduct problems of children with callous-unemotional traits. However, these studies have been cross-sectional. The present short-term longitudinal study investigates the bidirectional influences of parental monitoring and youth problem behaviors, while also examining the potential moderating influence of callous-unemotional traits.

Objective Poor condition at birth may impact on IQ, although its effect on other measures of neurodevelopment is unclear. The authors' aim was to determine whether infants receiving resuscitation after birth have reduced scores in measures of attention, memory and language skills or the need for educational support at school even in the absence of clinical encephalopathy. Methods Three groups of term infants were identifi ed from the Avon longitudinal study of parents and children: infants resuscitated at birth but asymptomatic for encephalopathy (n=612), infants resuscitated who developed symptoms of encephalopathy (n=40) and the reference infants who were not resuscitated and had no further neonatal care (n=8080). Measures of attention, language, memory and the need for educational support were obtained for children between 8 years and 11 years. Test results (standardised to a mean of 100 and SD of 15) were adjusted for clinical and social covariates. Missing covariate data were imputed using chained equations. Results Infants asymptomatic after resuscitation had similar scores to those not requiring resuscitation for all measures while infants who developed encephalopathy had lower working memory (−6.65 (−12.34 to −0.96)), reading accuracy (−7.95 (−13.28 to −2.63)) and comprehension (−9.32 (−14.47 to −4.17) scores and increased risk of receiving educational support (OR 6.24 (1.52 to 26.43)) than infants thought to be well at birth, although there was little evidence for an association after excluding infants who developed cerebral palsy. Conclusions The authors found no evidence that infants who were resuscitated but remained well afterwards differed from those not requiring resuscitation in the aspects of neuropsychological functioning assessed in this study. Infants who developed neonatal encephalopathy had evidence of worse functioning, particularly in language skills and were more likely to receive educational support at school.

Migrating to another country makes a person a newcomer in the receiving society. The current research investigates the impact of group-related approach and avoidance strategies on the psychological functioning of newcomers in the receiving society. Research in the interpersonal domain has demonstrated that approach strategies have positive effects and avoidance strategies negative effects on people&amp;amp;amp;#x27;s well-being. We propose that in an intercultural context group-related approach strategies also lead to a higher extent of well- ...

Although a wide variety of factors have been found to be related to health in some way, researchers on the subject of health generally fail to integrate $findings of other research disciplines within their own line of research. This study has attempted to bring together two research disciplines: ( a ) research on personality and health, and ( b ) research on socio-economical diflerences in health. Personality factors as well as social class have been found to mediate the stress-illness relation. Based on empirical and theoretical considerations, we proposed a simple model for the occurrence and course of disease. The personality factors studied were neuroticism, locus of control, and self-esteem. Socio-economic status (SES) was represented by education level, occupation status, and income. Health was operationalizedas the number of somatic diseases. The research questions were investigated (using t-tests andpath analysis) in a longitudinal set of data that were collected between 1970 and 1984 among 245 subjects in the normalpopulation. Neuroticism appeared to be an important mediator of the stressillness relation. Of the SES variables, occupation and education served as mediators; education was especially inJEuentia1 on the course of disease. The role of neuroticism is discussed.

Recently, structural MRI studies in children have been used to examine relations between brain volume and behavioral measures. However, most of these studies have been done in children older than 2 years of age. Obtaining volumetric measures in infants is considerably more difficult, as structures are less well defined and largely unmyelinated, making segmentation challenging. Moreover, it is still unclear whether individual anatomic variation across development, in healthy, normally developing infants, is reflected in the configuration and function of the mature brain and, as importantly, whether variation in infant brain structure might be related to later cognitive and linguistic abilities. In this longitudinal study, using T1 structural MRI, we identified links between amygdala volume in normally developing, naturally sleeping, 6-month infants and their subsequent language abilities at 2, 3 and 4 years. The images were processed and manually segmented using Cardviews to extract volumetric measures. Intra-rater reliability for repeated segmentation was 87.73% of common voxel agreement. Standardized language assessments were administered at 6 and 12 months and at 2, 3 and 4 years. Significant and consistent correlations were found between amygdala size and language abilities. Children with larger right amygdalae at 6 months had lower scores on expressive and receptive language measures at 2, 3, and 4 years. Associations between amygdala size and language outcomes have been reported in children with autism. The findings presented here extend this association to normally developing children, supporting the idea that the amygdalae might play an important but as yet unspecified role in mediating language acquisition.

Background/Objectives: To examine whether a relationship exists between exclusive breastfeeding duration and later vegetable consumption in 4-year-old children, independently of factors traditionally associated with children's vegetable intake. Subjects/Methods: A longitudinal study using information collected on children's food consumption patterns and behaviors from a representative sample of children born in 1998 in the province of Québec, Canada. Face-to-face interviews and self-administered questionnaires were addressed to children's mothers and fathers. From the first group of children (n ¼ 2100) included in the cohort, a subsample of 4-year-old children participated in a nutrition substudy (n ¼ 1549). Results: Children whose mothers held a university degree had odds of 8.7 (95% CI: 4.23-17.93) for consuming two or more servings of vegetables a day at 4 years of age (vs less than one serving per day) in comparison to children of mothers with no high school diploma. Likewise, children who were exclusively breastfed for 3 or more months had odds of 2.6 (95% CI: 1.34-5.02, with 3 to o4 months of exclusive breastfeeding) and 1.9 (95% CI: 1.01-3.61, with 4 or more months of exclusive breastfeeding) for consuming two or more servings of vegetables per day (vs less than one serving per day) in comparison to children who were formula-fed and/or partially breastfed (no exclusive breastfeeding). Conclusions: The findings suggest that three or more months of exclusive breastfeeding is a predictive factor for higher vegetable consumption in preschool children.

One of the most commonly raised concerns among those addressing alcohol consumption and young people is the close association between alcohol and sport (Sivyer, 1990). As a result, there is much current debate concerning the alcohol sponsorship of sporting events and teams. The authors are currently involved in a series of cross-sectional and longitudinal studies examining the nature, and effects,

Noncompliance with neuroleptic treatment is a major barrier to delivery of effective treatment for schizophrenia outpatients. This article describes the development of a standardized measure for the assessment of attitudinal and behavioral factors influencing patient compliance with neuroleptic treatment. The Rating of Medication Influences (ROMI) scale was developed as part of a longitudinal study of neuroleptic noncompliance in schizophrenia and administered to 115 discharged schizophrenia outpatients. Analyses of the following were conducted to assess the scale's psychometric properties: (1) interrater reliability, (2) internal consistency, (3) principal components, (4) correlation with other subjective measures, and (5) correlation with independent family reports. Most (95%) of the ROMI patient-report items were reliable, whereas rater-judgment items were not reliable. The rater section was dropped. A principal components analysis of the reliable patient-report items yielded three subscales related to compliance (Prevention, Influence of Others, and Medication Affinity) and five subscales related to noncompliance (Denial/ Dysphoria, Logistical Problems, Rejection of Label, Family Influence, and Negative Therapeutic Alliance). There were significant correlations between these subscales, and independently obtained family-report ROMI items were significant. The Denial/ Dysphoria subscale correlated strongly with two other published measures of dysphoric response to neuroleptics, whereas the other noncompliance sub-scales did not The ROMI is a reliable and valid instrument that can be used to assess the patient's subjective reasons for medication compliance and noncompliance. The subscale findings suggest that the ROMI provides a more comprehensive data base for patient-reported compliance attitudes than the other available subjective measures. Indications for use of the ROMI and other subjective measures of neuroleptic response are reviewed.

This study examined the developmental trajectories of parent-child relationships in adolescence, especially with respect to changes in support levels and negativity, and analyzed if and how these trajectories were associated with the subsequent quality of romantic relationships in young adulthood. A sample of 145 German subjects was followed across six waves (i.e., ages 14, 15, 16, 17, 21, and 23 years). Growth mixture modeling revealed three developmental trajectories of parent-child relationships across adolescence (i.e., normative, increasingly negative, and decreasingly negative/distant), which were associated with the quality of romantic outcomes at two times in emerging adulthood. Earlier mother-adolescent relationships were distinctively linked with connectedness and sexual attraction experienced in young adults' romantic relationships. Distant father-child relationships during adolescence were linked with the child's later anxious love.

Within the framework of stage-environment fit theory, the authors examined the contribution of family relations to adolescent outcomes concurrently and longitudinally, as well as the moderating effects of gender and ethnicity in these associations. Data came from a longitudinal study of European American and African American families from a range of socioeconomic backgrounds. Results demonstrated that gender and ethnicity influenced both the level and rate of change in family relations and adolescent outcomes. Family relations contributed either concurrently or longitudinally to at least 1 of the adolescent outcomes. The effects of gender and ethnic moderation differed according to both the time frame and the outcome assessed.

The research of body image among breast cancer patients is characterized by some limitations, such as the lack of longitudinal studies or the absence of a multidimensional perspective of body image. This study intends to overcome these limitations, by examining the evolution of body image dimensions (investment, emotions and evaluations) from the period of surgery (T1) to 6-months after the treatment’s ending (T2). It also aims to explore the predictors of body image at T2 and, simultaneously, the predictive role of initial body image to psychosocial adjustment at T2.A total of 56 breast cancer patients participated in both assessments and completed a battery of instruments that included measures of body image dimensions (appearance investment, self-consciousness of appearance, shame and appearance satisfaction) and psychosocial adjustment (quality of life and emotional distress).Within the dimensions of body image, only shame increased over time. In general, initial levels of investment predicted subsequent body image dimensions and having a mastectomy done was associated with higher shame and lower appearance satisfaction at T2. Initial body image did not predict later adjustment, with the exception of depression, where appearance investment played a relevant role.Our findings contributed to the advance of knowledge in this area, providing relevant data about the evolution of body image dimensions, its predictors and its predictive role on psychosocial adjustment among breast cancer patients. This study also suggested some clinical implications that can assist health professionals to implement strategies focused on body image throughout the disease.

Background  Trafficking in women is a widespread human rights violation commonly associated with poor mental health. Yet, to date, no studies have used psychiatric diagnostic assessment to identify common forms of mental distress among survivors returning to their home country. Methods  A longitudinal study was conducted of women aged 18 and over who returned to Moldova between December 2007 and December 2008

Research on learning pattern development in higher education contexts is scarce. In this longitudinal study the development of learning patterns of professional bachelor students is analyzed. Participants in the study were 254 students enrolled in eight different study disciplines. Vermunts&#39; Inventory of Learning Styles was used to assess individual differences in learning conceptions and learning strategies. By examining intra-individual changes

The purpose of the study was to assess the stability of expressed preferences for the use of life-sustaining treatments (LST) in severe illness conditions over two years. The two year longitudinal study included three structured interviews with a one-year interval (1994, 1995, and 1996). At baseline, 1138 Israeli elderly persons (70+) were interviewed, 802 and 638 were interviewed in the following stages. Stability over time was assessed on the basis of score dierences on two dierent indices that measured the wish to prolong life.

This study was to identify hysterectomy prevalence across urban, rural and remote areas of Australia and across states, to separate geographic variation from the effect of sociodemographic influences, and also to compare the quality of life of women who have and have not had hysterectomy. Data were collected from 14,072 women aged 45-50 years participating in the baseline survey of the Australian Longitudinal Study on Women&amp;#39;s Health. The estimated prevalence of hysterectomy was 22%. Factors significantly associated with hysterectomy included living in a rural or remote area, state of residence, having private health insurance, lower levels of education, being married and having more than two children, having had other gynaecological and non-gynaecological surgical procedures, and more visits to general practitioners. Compared with women who had not had hysterectomy, women who had had hysterectomy had significantly poorer physical and mental health as measured by the SF-36 quality of life profile (adjusted mean PCS=45.7 vs 49.3, p&amp;lt;0.0001; adjusted mean MCS=46.9 vs 48.2, p&amp;lt;0.0001).

Agency is-besides communion-a basic dimension of traits. It can be specifically linked to behavioral outcomes, to status, mastery, self-esteem and to success. The present paper analyzes the situational malleability of agency. Two studies tested whether an individual's agency (but not communion) is situationally influenced by the experience of success versus failure at a task, as well as whether this effect is the same for men and women. Supporting our hypotheses, the induction of success versus failure experiences led to changes in agency that were independent of actual performance, independent of type of task (memorizing vs. face recognition), independent of induction methodology (easy vs. difficult task vs. manipulated performance feedback), and independent of self-esteem, initial level of agency and of the participants' gender. Communion was not influenced by this kind of experience. Implications for both the basic dimension of agency and for theories on gender and gender stereotypes are discussed.

Objectives. The objectives of this study were 1) to assess whether there is an independent association between the level of prenatal cocaine exposure and infants' developmental test scores after control of potential confounding variables; and 2) if such an association exists, to determine which biological and social variables, individually and in interaction with each other, may modify it. Methods. In a prospective, longitudinal study of 203 urban term infants, 3 cocaine exposure groups were defined by maternal report and infant meconium assay: unexposed, heavier cocaine exposure (>75th percentile self-reported days of use or meconium benzoylecognine concentration), or lighter cocaine exposure (all others). Examiners, masked to exposure history, tested infants at 6, 12, and 24 months of age with the Bayley Scales of Infant Development. Results. The final mixed linear regression model included as fixed covariates level of prenatal exposure to cocaine, alcohol, and cigarettes; prenatal marijuana exposure; gestational age and birth weight z score for gestational age; and gender. Age at test, caregiver at time of each test (biological mother, kinship caregiver, unrelated foster caregiver), and any previous child-focused early intervention were included as time-dependent covariates. There were no significant adverse main effects of level of cocaine exposure on Mental Development Index (MDI), Psychomotor Development Index (PDI), or Infant Behavior Record. Child-focused early intervention interacted with level of cocaine exposure such that heavily exposed children who received such intervention showed higher adjusted mean MDI scores than all other groups. Although the sample was born at or near term, there was also a significant interaction of cocaine exposure and gestational age on MDI scores, with those in the heavier exposure group born at slightly lower gestational age having higher mean MDI scores compared with other children born at that gestational age. There was also a significant interaction on MDI between child's age and caregiver. At 6 months, the adjusted MDI of children living with a kinship caregiver was 15.5 points lower than that of children living with their biological mother, but this effect was diminished and was no longer significant at 24 months (difference in means: 4.3 points). The adjusted mean MDI of children in unrelated foster care at 6 months was 8.2 points lower than children of biological mothers, whereas it was 7.3 points higher at 24 months. Early intervention attenuated the age-related decline in PDI scores for all groups. Birth weight <10th percentile was associated with lower PDI scores for children with heavier cocaine exposure and with lower MDI scores for all groups. Conclusions. Heavier prenatal cocaine exposure is not an independent risk factor for depressed scores on the Bayley Scales of Infant Development up to 24 months of age when term infants are compared with lighter exposed or unexposed infants of the same demographic background. Cocaine-exposed infants with birth weight below the 10th percentile for gestational age and gender and those placed with kinship caregivers are at increased risk for less optimal developmental outcomes. Pediatric clinicians should refer cocaine-exposed children to the child-focused developmental interventions available for all children at developmental risk.

In this paper we analyse data from the National Education Longitudinal Study to investigate whether experiencing parental divorce during adolescence has an adverse impact on students'performance on standardized tests. To account for the potential endogeneity of parental divorce we employ double and triple di¤erences models that rely on observing teenagers from intact and divorced backgrounds before and after the divorce occurs. We …nd that parental divorce does not negatively a¤ect teenagers' cognitive skills. Our results also suggest that cross-section estimates overstate the detrimental e¤ect of parental divorce. We thank the U.S. Department of Education's National Center for Education Statistics for access to the public use NELS data and Jennifer Thompson for kindly answering our questions about the data …les. Seminar participants at the EUI, UNICEF and CSEF gave very helpful comments on earlier drafts.

Learning protocols are a self-guided way of writing that allows for elaboration and reflection on learning content. In an experimental study (N = 103), we supported protocol writing with prompts to elicit important strategies as postulated by a cyclical model of selfregulated learning. Students received either (a) no prompts, (b) cognitive prompts, (c) metacognitive prompts, (d) mixed prompts without, or (e) including prompts for planning of remedial strategies. Prompting all essential sub-processes of self-regulated learning (group e) fostered students' comprehension best. Thus, with appropriate support, writing can serve as a beneficial medium helping students to self-regulate their understanding of subject matter.

Dilated cardiomyopathy (DCM) is a major cause of morbidity and mortality in various dog breeds. The diagnosis of overt DCM is not normally problematic, although the importance of active exclusion of other causes of the dilated, hypokinetic heart is emphasised. Recent interest in human familial DCM has prompted a number of researchers to investigate the genetic basis of canine DCM. Prospective screening of dogs from lines with familial prevalence of DCM may identify dogs with pre-clinical ("occult") DCM. Dogs with other echocardiographic abnormalities or arrhythmias may also be identified. It is clear that dogs, like humans, have a prolonged pre-symptomatic phase of the disease extending over years. The ESVC DCM taskforce was established to provide the veterinary cardiology community with guidelines for the diagnosis of DCM, predominantly based on 2D and M-mode echocardiography. Diagnosis of DCM requires all of the following: (i) Left ventricular dilatation (ii) Reduced systolic function (iii) Increased sphericity of the left ventricle. We propose a scoring system for the identification of dogs in the pre-clinical stages. These include a number of major criteria and minor criteria. Future prospective longitudinal studies are required to test these in different breed populations to assess their predictive power and further refinements may be required. The importance of post mortem confirmation of disease is emphasised, and the two major histopathological features associated with DCM, the attenuated wavy fibre and the fibro-fatty infiltration-degenerative forms, require further investigation to identify the different aetiopathogenetic factors which may be involved.

Evidence linking home hazards to falls has not been well established. The evidence-based approach to fall-risk assessment in longitudinal studies becomes difficult because of exposures that change during follow-up. We conducted a cohort study to determine the prevalence of hazards and to resolve whether they are linked to the risk of falls among 959 seniors receiving home-care services. A home hazards assessment was completed at entry and every six months thereafter using a standardized form. The adjusted (for a number of confounding factors) relationship between home hazards and falls was estimated using a survival model taking into account updated time-varying exposures and multiple events. Falls leading to a medical consultation were examined as a secondary outcome, hypothesized as a measure of severity. Home environmental hazards were found in 91% of homes, with a mean of 3.3 risks per individual. The bathroom was the most common place for hazards. The presence of hazards was si...

This paper investigates the effect of different levels of neighbourhood housing tenure mix on transitions from unemployment to employment and the probability of staying in employment for those with a job. We used individual level data from the Scottish Longitudinal Study (SLS), a 5.3% sample of the Scottish population, covering a 10 year period. We found a strong negative correlation between living in deprived neighbourhoods and labour market outcomes (getting or keeping a job). We found a small, but significant, positive correlation between living in mixed tenure (40-80% social housing) streets and transitions from unemployment to employment. In the conclusion we discuss the extent to which we think these results can be interpreted as 'neighbourhood effects' or selection effects.

To examine predictors of cannabis use initiation, continuity and progression to daily use in adolescents. Design. Population-based cohort study over 3 years with 6 waves of data collection. Participants. 2032 students, initially aged 14-15 years, from 44 secondary schools in the state of Victoria, Australia. Measurements. Self-report cannabis use was categorized on four levels (none, any, weekly, daily) and summarized as mid-school (waves 2/3) and late-school (waves 4/5/6) use. Background, school environment, mid-school peer use and individual characteristics were assessed. Findings. Peer cannabis use, daily smoking, alcohol use, antisocial behaviour and high rates of school-level cannabis use were associated with mid-school cannabis use and independently predicted late-school uptake. Cannabis use persisted into late-school use in 80% of all mid-school users. Persisting cannabis use from mid-to late-school was more likely in regular users (odds ratio (OR) 3.4), cigarette smokers (OR any smoking: 2.0, daily smoking: 3.3) and those reporting peer use (OR 2.1). Mid-school peer use independently predicted incident late-school daily use in males (OR 6.5) while high-dose alcohol use (OR 6.1) and antisocial behaviour (OR 6.6) predicted incident late-school daily use in females. Conclusions. Most cannabis use remained occasional during adolescence but escalation to potentially harmful daily use in the late-school period occurred in 12% of early users. Transition was more likely in males, for whom availability and peer use were determinants. In contrast, females with multiple extreme behaviours were more likely to become daily users. Cigarette smoking was an important predictor of both initiation and persisting cannabis use.

This follow-up study examined the current functioning of young adult alumni of a large network of grouphomes in Israel. Our aim was to identify factors explaining their current functioning and explore gender differences. Background and in-care experiences were gathered on 143 alumni (64 men and 79 women). One hundred nine of those alumni (51 men and 58 women) agreed to be interviewed. Despite their disadvantaged background prior to entering care, alumni functioned adequately and were in good health. Girls seem to have more positive in-care experiences than boys. A child's academic functioning while in care was a positive predictor for alumni current functioning status. Our study identifies areas of concern such as alumni relative low educational level, and suggests directions for future interventions and longitudinal studies. D

For the purpose of studying the potential neurobehavioral effects of different human apolipoprotein E (apoE) isoforms produced within the brain, transgenic (TG) mice were generated in which human apoE3 or apoE4 isoforms were under control of an astrocyte-specific, glial fibrillary acidic protein promoter and these TG mice were bred back to apoE knockout (KO) mice. Behavioral phenotypes of apoE3 and apoE4 TG mice were derived by conducting a longitudinal study in which apoE3 and apoE4 TG mice were compared with apoE KO and wild-type (WT) mice (all male) on several behavioral measures. Analysis of locomotor activity, &amp;quot;open-field&amp;quot; behaviors, acoustic startle/prepulse inhibition, and elevated plus maze data suggested that the apoE TG/KO groups were more &amp;quot;emotionally reactive&amp;quot; than WT mice, with apoE4 mice typically being the most reactive. The absence of performance differences among groups on the rotating holeboard and water navigation tasks suggested intact reference memory processing in apoE TG/KO mice. However, apoE4 mice were profoundly impaired on a working memory-based protocol in the radial arm maze (11-14 months). Nonassociative factors (sensorimotor capacities or emotionality differences) did not appear to confound interpretation of the learning/memory results. Western blot analysis revealed no alterations in the level of synaptic, neuronal, or glial markers in neocortex or hippocampus and histologic analysis revealed no evidence of Abeta deposition or neuritic plaques in the apoE KO/TG mice. Our findings suggest that apoE4 expression in the brain may have selective deleterious effects on memory function in the absence of typical Alzheimer&amp;#39;s-like neuropathology.