IN VIVO PHARMACOLOGICAL INVESTIGATION OF MIMOSA PUDICA L.
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Abstract
Objective: To evaluate the anti-nociceptive, acute toxicity, gastro intestinal motility, anti-pyretic investigations of leaf extract of Mimosa pudica L. leaves in Swiss albino mice following oral administration. Methods: In-vivo anti-nociceptive activity test was evaluated by tail immersion test. In-vivo acute toxicity test was conducted using acute toxic class method. In-vivo gastrointestinal motility was determined by charcoal feces defecation time. In-vivo antipyretic activity test was evaluated by brewer’s yeast induced pyrexia. Results: In-vivo anti-nociceptive activity test shows that methanol & ethanol extracts (250 & 500 mg/kg b.w.) performed significant activity (p<0.05) in mice comparing to the standard drug diclofenac Na. In-vivo acute toxicity test was done on mice with methanol, ethanol and chloroform extracts (2000, 1000, 500 mg/kg b.w.) of Mimosa pudica leaf and no reaction or death occurred in mice during two weeks of observation. In-vivo gastrointestinal motility test indicates significant (p<0.01) increase in gastrointestinal motility by ethanol extracts of (250 & 500 mg/kg b.w.) comparing to the standard drug loperamide. In-vivo antipyretic activity test shows that methanol (250 & 500 mg/kg b.w.), ethanol (250 & 500 mg/kg b.w.) and chloroform (250mg/kg b.w.) extracts showed significant (p<0.05) reduction in temperature of mice comparing to the standard drug paracetamol. Conclusion: The result of the study indicates analgesic, antipyretic properties along with gastrointestinal motility stimulating effects. According to the acute toxicity study, the leaf extracts are safe up to 2000 mg/kg in-vivo concentration.
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Research Article IN VIVO PHARMACOLOGICAL INVESTIGATION OF MIMOSA PUDICA L
2013
Objective: To evaluate the anti-nociceptive, acute toxicity, gastro intestinal motility, anti-pyretic investigations of leaf extract of Mimosa pudica L. leaves in Swiss albino mice following oral administration. Methods: In-vivo anti-nociceptive activity test was evaluated by tail immersion test. In-vivo acute toxicity test was conducted using acute toxic class method. In-vivo gastrointestinal motility was determined by charcoal feces defecation time. In-vivo antipyretic activity test was evaluated by brewer’s yeast induced pyrexia. Results: In-vivo anti-nociceptive activity test shows that methanol & ethanol extracts (250 & 500 mg/kg b.w.) performed significant activity (p<0.05) in mice comparing to the standard drug diclofenac Na. In-vivo acute toxicity test was done on mice with methanol, ethanol and chloroform extracts (2000, 1000, 500 mg/kg b.w.) of Mimosa pudica leaf and no reaction or death occurred in mice during two weeks of observation. In-vivo gastrointestinal motility...
IN-VIVO ANTI-PYRETIC, ANTI-NOCICEPTIVE, NEUROPHARMACOLOGICAL ACTIVITIES AND ACUTE TOXICITY INVESTIGATIONS OF BLUMEA LACERA Original Article
International journal of Pharmacy and Pharmaceutical Sciences, 2015
Objective: The present study was done to evaluate in vivo anti-pyretic, neuropharmacological activity including open field and swimming test, gastrointestinal motility, anti-nociceptive and acute toxicity effect of different leaf extracts of Blumea lacera in Swiss albino mice following oral administration. Methods: In-vivo antipyretic test of methanol, ethanol and chloroform extracts of Blumea lacera leaf was done brewer's yeast method; neuropharmacological study was performed by open field test and swimming test, GI motility test was done by charcoal induced anti motility test, anti-nociceptive activity was tested by acetic acid induced writhing method and acute toxicity study was done by investigating mortality/morbidity status of test animal. Results: In-vivo antipyretic activity shows methanol extracts at a dose of 400 mg/kg b. w., both the doses of ethanol extract and chloroform extract at a dose of 200 mg/kg b. w. produced significant (p<0.05) reduction of temperature in mice comparing to the standard drug diclofenac Na. In-vivo neuropharmacological activity study yields significant results when methanol 100 mg/kg, ethanol 200 mg/kg, chloroform 100 & 200 mg/kg extracts were administered to evaluate the rate of movement with time in a dose dependent manner when compared with the corresponding value of control group. In gastrointestinal motility test methanol extract at 250 mg/kg, ethanol extract at 250 & 500 mg/kg and chloroform 250 mg/kg doses significantly reduce GI motility when compared to standard drug loperamide. Statistically significant (p <0.001, p<0.02, p<0.05) results were found in in-vivo anti-nociceptive activity test for the 100 mg/kg chloroform, 100 mg/kg methanol and 200 mg/kg ethanol respectively when compared to standard diclofenac-Na. None of the extracts showed any significant in-vivo acute toxicity effect on mice. Conclusion: This plants leaf extracts exhibit potent antipyretic acitivities; significant neuropharmacological activities and significant antinociceptive activity without inducing any discernible acute toxicity effect.
EVALUATION OF THE ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF ETHANOL EXTRACT OF THE ROOT OF MIMOSA PIGRA LINN (FABACEAE) IN ALBINO RATS Original Article
International Journal of Pharmacy and Pharmaceutical Sciences, 2015
Objective: Mimosa pigra roots are used in traditional medicine in the treatment of fever, headaches and cold. This study investigated the ethanol extract of the root of Mimosa pigra for its analgesic and anti-inflammatory activities in albino rats. Methods: The analgesic activity was evaluated by radiant heat tail flick method while the anti-inflammatory effect was investigated using fresh egg albumin induced paw edema in rats. The plant extract was evaluated at 250 mg/kg and 500 mg/kg. All administrations were done through the oral route. Results: Preliminary phytochemical screening showed that the extract contains; steroids, tannins, flavonoids, phlobatanins, saponins. The LD50 was found to be greater than 5000 mg/kg. The results showed that oral administration of 250 mg/kg of Mimosa pigra showed significantly (P<0.05) analgesic activity in30, 60 and 150 minutes while 500 mg/kg produced significantly (P<0.05) analgesic activity in 30, 60, 120 and 150 minutes. The two tested doses (250 mg/kg and500 mg/kg) were found to produce percentage inhibition of rat paw edema (42.60% and 49%) at 150 minutes compared to the positive control group of 63.20%. Conclusion: The findings of this study showed that the ethanol extract of this plant possesses significant anti-inflammatory and analgesic activities.
Anti-Pyretic and Analgesic Potentials of Aqueous Extract of Phragmanthera capitata S. Balle in Albino Rats
Phragmanthera capitata is parasitic plant (mistletoe) that colonizes many plants including avocado trees. The whole plant infusion/decoction is used in Cameroon folk medicine to relief fever and abdominal pain. This study was aimed at assessing anti-pyretic and analgesic potentials of aqueous extract of Phragmanthera capitata (AEPC) in Wistar rats at doses of 100, 200 and 300 mg/kg body weight. To assess anti-pyretic potential; 2, 4-dinitrophenol (DNP) and turpentine were used to induce pyrexia with standard drug being diclofenac sodium (50 mg/kg). To assess peripheral analgesic effect, acetic acidinduced writhing test was used. To assess central analgesic potential, formalin-induced licking test was used with standard drug being pethidine (5 mg/kg). Data obtained were analyzed using analysis of variance (ANOVA) with Tukey test used as post hoc. In DNP-induced pyrexia, results revealed that AEPC at 200 and 300 mg/kg significantly (P <0.05 and P <0.01) reduced rat body temperature by 0.80±0.02 and 1.20±0.10 O C respectively as compared to 0.90±0.05 O C for standard drug. In turpentine induced pyrexia, same inhibition trend was shown as in DNP induced pyrexia. In peripheral analgesic activity, AEPC (300 mg/kg) maximally inhibited (P <0.05) number of writhes to 4.25±0.10 as compared to 9.27±0.51 for standard drug and 31.50±2.32 for control. In central analgesic activity, the number of licks was reduced to 4.99±0.13 as compared to 4.21±0.09 for standard drug and 39.25±3.13 for control. Therefore, AEPC possesses enormous anti-pyretic and analgesic properties in a dose-dependent manner. These properties corroborate the extract being used in Cameroon folk medicine to relief fever and abdominal pain.
Evaluation of the Analgesic and Anti-Inflammatory Activities of Ethanol Extract of the Root of Mimosa Pigra Linn (Fabaceae) in Albino Rats
2015
Objective: Mimosa pigra roots are used in traditional medicine in the treatment of fever, headaches and cold. This study investigated the ethanol extract of the root of Mimosa pigra for its analgesic and anti-inflammatory activities in albino rats.Methods: The analgesic activity was evaluated by radiant heat tail flick method while the anti-inflammatory effect was investigated using fresh egg albumin induced paw edema in rats. The plant extract was evaluated at 250 mg/kg and 500 mg/kg. All administrations were done through the oral route.Results: Preliminary phytochemical screening showed that the extract contains; steroids, tannins, flavonoids, phlobatanins, saponins. The LD50 was found to be greater than 5000 mg/kg. The results showed that oral administration of 250 mg/kg of Mimosa pigra showed significantly (P<0.05) analgesic activity in30, 60 and 150 minutes while 500 mg/kg produced significantly (P<0.05) analgesic activity in 30, 60, 120 and 150 minutes. The two tested do...
Analgesic Profile of the Aqueous and Methanol Extracts of Alchornea Laxiflora in Albino Mice
The study investigated the median lethal dose and the effects of the aqueous and methanol extracts of Alchornea laxiflora in three mouse models of central and peripheral analgesia, the hot plate, acetic acid-induced abdominal writhes and the tail immersion tests. This was with a view to providing information on the acute toxicity, analgesic effects and the possible mechanism of analgesia. The LD50 for the aqueous and methanol extracts of A. laxiflora in the oral route was > 1600 mg/kg respectively, and found to be safe in animals. However, the LD50 (i.p.), was found to be 400 mg/kg for the methanol extract, which was relatively toxic and > 1600 mg/kg for the aqueous extract. Mice of both sexes (n=6) weighing 18 – 22 g were used for the study, which were randomised into control and test, which summed up to eight (VIII) groups. The control group (I) received 10 % Tween 80 (vehicle), 0.1 ml/10 g mouse while the test groups (II,III,IV,V,VI) were administered graded doses (100, 200, 400, 800, 1600 mg/kg, p.o.) of the extracts. The reference groups (VII,VIII) received standard drugs, Acetyl salicylic acid (10 mg/kg, i.p.) and Pethidine (10 mg/kg, i.p.). The animals were observed for their reaction to pain using different noxious stimuli (thermal and chemical). They were appropriately scored individually after observation 30 and 60 min post intra-peritoneal and oral administrations of vehicle, extracts or drugs respectively.
In-vivo Assessment of Neuropharmacological Activity of Methanol Bark Extract of Mimosa pudica in Mice
Advances in Pharmacology and Pharmacy, 2019
Background: Mimosa pudica, a common plant of Mimosoideae family has been used as Ayurvedic herbal medicine by Bangladeshi and Chinese to treat several diseases such as hemorrhoids, hair loss, arthritis, dysentery, leprosy, jaundice, leukoderma, asthma, uterine problems. The root and bark of the plant is said to display antimicrobial activity. Hence, gargling with a decoction of the root and bark of Mimosa pudica diluted in water may help to treat toothaches. Aim of the study: The present study was designed to evaluate the presence of phytochemical groups and to investigate the neuropharmacological activity of methanol extract of Mimosa pudica (MEMP). Methodology: The neuropharmacological activity was determined by hole cross and open field test using Swiss Albino mice as experimental animal. Results: Phytochemical analysis of Mimosa pudica extract indicated the presence of tannins, alkaloids, terpenoids and flavonoids. The sample showed dose-dependent sedative activity at the doses of 200 and 400 mg/kg body weight compared to standard drug Diazepam (1 mg/kg body weight). Conclusion: MEMP showed significant sedative activity demonstrating that the extract may be useful in the development of a new sedative and anti-anxiety drug.
Antinociceptive potential of methanol leaf extracts of Cissampelos parreira (Linn), Lantana camara (Linn) and Ocimum gratissimum (African basil
Journal of Advanced Biotechnology and Experimental Therapeutics, 2021
The effects of Cissampelos pareira (Linn), Lantana camara (Linn) and Ocimum gratissimum (African basil) leaf extracts on pain have not been biologically determined despite their frequent traditional use in pain management. The present study evaluated the effects of methanol leaf extracts of these three plants on formalin-induced pain in Swiss albino mice. Leaves of C. pareira, L. camara, and O. gratissimum were harvested, cleaned, shade dried, crushed, extracted in absolute methanol and concentrated to dryness. The quantitative phytochemical screening of the three plant extracts was first carried out. Then, the pain assay tests constituted eight groups of five mice each: normal control group, positive control group, negative control group and experimental groups of 50, 100, 150, 200 and 250 mg/kg bw extracts. The animals were administered with various treatments thirty minutes before induction of pain through injection of 0.01 ml of 2.5% formalin solution into the sub-plantar region of the left hind paw. Paracetamol at the dose of 50 mg/kg bw and 5% dimethyl sulfoxide were used as the positive and negative controls respectively. The plant extracts were administered intraperitoneally and orally. Data was analyzed using one-way analysis of variance and unpaired t-test. Phytochemical screening on separate extracts of C. pareira, L. camara, and O. gratissimum revealed fatty acids, phenols, flavonoids and terpenoids. The different dosages of methanol leave extracts of C. pareira, L. camara, and O. gratissimum reduced pain significantly (p˃0.05) in mice. The significant reduction of pain was associated with fatty acids, phenols, flavonoids and terpenoids revealed in the plant extracts.
Pain management in mice using the aqueous and ethanol extracts of four medicinal plants
East African Medical Journal, 2004
Background: There are many traditionally used analgesic plants in Ethiopia. They, however, have not been subject to scientific investigation for their efficacy and safety. Objective: To evaluate both prophylactic and relieving effects of aqueous and ethanol extracts of four traditionally used medicinal plants in Ethiopia. Design: An experimental design in which five group of albino mice weighing 30-35 grams representing positive and negative control, and extract treated groups respectively. The extracts, standard drugs and normal saline were administered into GIT by gavage to evaluate the analgesic effect.
Anti-diarrhoeagenic Properties of Aqueous Extract of Phragmanthera capitata S. Balle in Albino Rats
European Journal of Medicinal Plants, 2014
Phragmanthera capitata is parasitic plant (mistletoe) that colonizes many plants including avocado trees. The whole plant infusion/decoction is used in Cameroon folk medicine to relief fever and abdominal pain. This study was aimed at assessing anti-pyretic and analgesic potentials of aqueous extract of Phragmanthera capitata (AEPC) in Wistar rats at doses of 100, 200 and 300 mg/kg body weight. To assess anti-pyretic potential; 2, 4-dinitrophenol (DNP) and turpentine were used to induce pyrexia with standard drug being diclofenac sodium (50 mg/kg). To assess peripheral analgesic effect, acetic acidinduced writhing test was used. To assess central analgesic potential, formalin-induced licking test was used with standard drug being pethidine (5 mg/kg). Data obtained were analyzed using analysis of variance (ANOVA) with Tukey test used as post hoc. In DNP-induced pyrexia, results revealed that AEPC at 200 and 300 mg/kg significantly (P <0.05 and P <0.01) reduced rat body temperature by 0.80±0.02 and 1.20±0.10 O C respectively as compared to 0.90±0.05 O C for standard drug. In turpentine induced pyrexia, same inhibition trend was shown as in DNP induced pyrexia. In peripheral analgesic activity, AEPC (300 mg/kg) maximally inhibited (P <0.05) number of writhes to 4.25±0.10 as compared to 9.27±0.51 for standard drug and 31.50±2.32 for control. In central analgesic activity, the number of licks was reduced to 4.99±0.13 as compared to 4.21±0.09 for standard drug and 39.25±3.13 for control. Therefore, AEPC possesses enormous anti-pyretic and analgesic properties in a dose-dependent manner. These properties corroborate the extract being used in Cameroon folk medicine to relief fever and abdominal pain.
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Antihyperglycemic and antinociceptive activity of Fabaceae family plants – an evaluation of Mimosa pigra L. leaves
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IN VITRO ANTIOXIDANT ACTIVITIES AND IN VIVO ANTI-NOCICEPTIVE AND NEUROPHARMACOLOGICAL ACTIVITIES OF MIMOSA PUDICA
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iosrphr.org
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