Anti�hyperlipidemic Effect of Triglize, a Polyherbal Formulation

ABSTRACT Anti‐hyperlipidemic property of Triglize, a polyherbal formulation was determined in male albino Wistar rats. The aqueous extract of polyherbal formulation (PHF) triglize was used for the study. The animals were fed with high fat diet to induce hyperlipidemia . The test (polyherbal formulation) and standard drugs were administered once dally as a single oral dose for 28 days. The test drug administered at the dose levels of 25, 50, 100 and 200 mg/kg and standard drug atorvastatin was administered at the dose level of 10 mg/kg. Weekly body weight variation, lipid profile (total cholesterol, triglyceride, HDL, VLDL and LDL levels, HDL ratio and atherogenic index) were analyzed and day of the termination the liver was isolated from the all the animals and subjected to histopathological evaluation. End of the experiments liver markers like ASAT, ALAT were analyzed in serum samples. High fat diet showed significant increase in body weight, lipid profile in serum. The polyherbal formulation and atorvastatin treated groups showed significantly increased HDL levels and decreased total cholesterol, triglyceride, LDL, VLDL, HDL ratio and atherogenic index. End of the study atorvastatin elevated the ASAT and ALAT levels. The PHF has been found significant anti‐hyperlipidemic and hepatoprotective action.