Sweet Syndrome secondary to infection: A case report

Journal of Investigative Medicine High Impact Case Reports

Sweet’s syndrome, also known as acute febrile neutrophilic dermatosis, is a rare disorder that typically presents with rapid appearance of tender skin lesions accompanied by fever and leukocytosis with neutrophilia. Its pathogenesis is not fully understood. The syndrome is generally classified into classical, malignancy-associated, and drug-induced categories, each of which has its specific characteristics. In this article, we present a case of classical Sweet’s syndrome in a woman who presented with an acute viral illness.

Case Reports in Immunology, 2014

A 7-year-old boy with high grade fever (39 ∘ C) and warm, erythematous, and indurated plaque above the left knee was referred. According to the previous records of this patient, these indurated plaques had been changed toward abscesses formation and then spontaneous drainage had occurred after about 6 to 7 days, and finally these lesions healed with scars. In multiple previous admissions, high grade fever, leukocytosis, and a noticeable increase in erythrocyte sedimentation rate and C-reactive protein were noted. After that, until 7th year of age, he had shoulder, gluteal, splenic, kidney, and left thigh lesions and pneumonia. The methylprednisolone pulse (30 mg/kg) was initiated with the diagnosis of Sweet's syndrome. After about 10-14 days, almost all of the laboratory data regressed to nearly normal limits. After about 5 months, he was admitted again with tachypnea and high grade fever and leukocytosis. After infusion of one methylprednisolone pulse, the fever and tachypnea resolved rapidly in about 24 hours. In this admission, colchicine (1 mg/kg) was added to the oral prednisolone after discharge. In the periodic fever and neutrophilic dermatosis, the rheumatologist should search for sterile abscesses in other organs.

International journal of dermatology, 2010

Sweet's syndrome (SS) is an uncommon disorder characterized by the abrupt onset of erythematous papules and plaques that histologically exhibit diffuse dermal neutrophilic infiltrate and edema. There are usually associated constitutional symptoms such as fever, neutrophilia, elevated serum inflammatory markers, and associated disorders. The aim of this study was to assess the clinical and histologic features of all patients diagnosed with SS at our institution between 1971 and 2008 and to compare their findings with those published in the literature. Retrospective review of 44 cases of SS diagnosed at the American University of Beirut - Medical Center between 1971 and 2008. Data collected included clinical (age, gender, morphology and distribution of lesions, associated symptoms and disorders, therapy) and histologic features, as well as laboratory abnormalities. Most of our patients showed the typical clinical, histologic, and laboratory abnormalities characteristic of SS. Of o...

International Journal of Dermatology, 2006

Sweet's syndrome is rare in children. Usually, heralded by tender polymorphous skin lesions, typically accompanied by fever and peripheral neutrophilia, can easily be mistaken for infection and lead to many antibiotic administration. Such therapy does not improve disease, which is thought to represent an immunologic reaction to agents as diverse as infection, neoplasia, or drugs. We report two boys, six and nine-year-old who suffered from acute febrile neutrophilic dermatosis. Both were febrile, had leukocytosis, and exhibited characteristic clinical and histopathologic lesions. They had an antecedent trauma, and responded to systemic corticosteroids. Our evaluation and long term follow-up of these children failed to reveal evidence of underlying malignancy or a chronic systemic illness typically encountered in Sweet's syndrome.

Current Health Sciences Journal, 2020

Introduction. Sweet syndrome (SS), also denominated as acute febrile neutrophilic dermatosis, is a rare disease characterized by the sudden onset of painful, erythematous, firm skin lesions (papules, plaques, and nodules) which show, upon histologic examination, the presence of a diffuse infiltrate of mature neutrophils. The cutaneous manifestation typically involves the face, neck, trunk, and upper limbs and is associated with fever, general malaise, arthralgia. Case report. A female patient, 60 years old, attended the Dermatology Clinic due to the appearance of violaceous erythematous-oedematous infiltrated plaques, located on the face, neck, upper limbs, trunk and knees. The onset of the cutaneous manifestation had occurred 2 months prior, accompanied by pain, chills, flares of fever and arthralgia. The onset coincided with the surgical treatment of an umbilical hernia. From the medical history we note that the patient was diagnosed in 2014 with histiocytoid SS. She followed a tr...

International Journal of Dermatology, 2006

Sweet's syndrome is considered a variable manifestation of hypersensitivity to several antigens. Many etiological factors, including drugs, infectious, inflammatory, neoplastic and miscellaneous disorders, have been reported to be associated with this syndrome. We report the case of a patient who subsequently developed inflammatory dermatophytosis and Sweet's syndrome; an association not previously described.

Australasian Journal of Dermatology, 2007

A 38-year-old woman developed an acute, painful cutaneous eruption on her lower legs, neck, chest and fingers while receiving a number of oral and intravenous antibiotics for left leg cellulitis caused by trauma. Clinically and histopathologically, she was diagnosed with Sweet s syndrome with typical pseudovesicular skin changes in conjunction with erythema nodosum-like lesions on her lower legs. She responded quickly to oral prednisolone. We propose Staphylococcal cellulitis as a cause of Sweet s syndrome.

International Journal of Research in Dermatology, 2017

Sweet's syndrome (SS) or acute febrile neutrophilic dermatoses was originally described by Robert Douglas Sweet in 1964. It is characterized by fever, leucocytosis, and sudden onset of painful, erythematous papules, nodules or plaques histopathologically characterized by a dense dermal infiltrate of neutrophils with prominent papillary dermal oedema sometimes severe enough to produce subepidermal vesiculation or bullae. This condition is highly responsive to corticosteroids. 2 There are various clinical subtypes of SS which include classical or idiopathic, respiratory or gastrointestinal tract infection related, drug induced, autoimmune disease

Journal of College of Medical Sciences-Nepal, 2012

Sweet's syndrome (the eponym for acute febrile neutrophilic dermatosis) is characterized by a constellation of clinical symptoms, physical features, and pathologic findings which include fever, neutrophilia, tender erythematous skin lesions (papules, nodules, and plaques), and a diffuse infiltrate consisting predominantly of mature neutrophils that are typically located in the upper dermis without vasculitis. To study the clinico-pathological features, clinical course and treatment of patients with sweets syndrome. A retrospective observational analysis of 12 diagnosed cases of sweet’s syndrome attending and admitted in the Department of Dermatology from June 2003- April 2009 were considered in this study. The study comprised of 9 females and 3 males (3:1) between the age group of 22-73 years. Typical lesions of sweets syndrome were present in all cases and the duration of illness ranged from 3-8 days. Constitutional symptoms of fever, pain and malaise were present in all and th...