Naïve CD4+ T-cell activation Boolean network model

<p>The network consists of 182 links and 118 nodes (including Boolean operators), 19 of which are input nodes, i.e., no link points to them (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0176500#pone.0176500.s001" target="_blank">S1 Table</a>). The Boolean network represents the naïve CD4+ T-cell activation events. The boxes represent non-PID (white) and PID proteins (gray). Spheres denote the AND gate. Activating links have a pointed head and solid line while inhibiting links have a blunt head and dashed line. Signal 1 represents peptide-MHC/TCR complex while Signal 2 represents co-receptor-ligand association, e.g. CD80-B7. Since the network focuses on TCR/CD28 signaling events, some events, e.g. for survival signaling that occur after antigen mediated T-cell activation and response through interleukin 2 (IL2), have not been fully considered.</p