Erlang Computation GSM Design

Molecules, 2013

Neglected Tropical Diseases (NTDs), like leishmaniasis, are major causes of mortality in resource-limited countries. The mortality associated with these diseases is largely due to fragile healthcare systems, lack of access to medicines, and resistance by the parasites to the few available drugs. Many antiparasitic plant-derived isoprenoids have been reported, and many of them have good in vitro activity against various forms of Leishmania spp. In this work, potential Leishmania biochemical targets of antiparasitic isoprenoids were studied in silico. Antiparasitic monoterpenoids selectively docked to L. infantum nicotinamidase, L. major uridine diphosphate-glucose pyrophosphorylase and methionyl t-RNA synthetase. The two protein targets selectively targeted by germacranolide sesquiterpenoids were L. major methionyl t-RNA synthetase and dihydroorotate dehydrogenase. Diterpenoids generally favored docking to L. mexicana glycerol-3-phosphate dehydrogenase. Limonoids also showed some selectivity for L. mexicana glycerol-3-phosphate dehydrogenase and L. major dihydroorotate dehydrogenase while withanolides docked more selectively with L. major uridine diphosphate-glucose pyrophosphorylase. The selectivity of the different classes of antiparasitic compounds for the protein targets considered in this work can be explored in fragment-and/or structure-based drug design towards the development of leads for new antileishmanial drugs.

Efficiency of tower cranes largely depends on their location, and the supply point position which has a significant contribution to crane cycle time. The current trend in practice for crane positioning is to rely on experience than a technique, and the existing methods in literature suffer from some shortcomings such as predetermined crane and supply locations and two-dimensional (2D) representation of the results. Therefore, the main aim of the present study is to propose a model to find the optimum tower crane and supply point locations in the site and the associated minimum completion time. The proposed model includes radial velocity, tangent velocity, crane working radius (CWR), considers a three-dimensional (3D) movement of the materials by crane and generates a heatmap visualization of the whole site. For this purpose, a model is initially proposed for the analytical modeling of average transportation time (ATT), and afterward, the flowchart of the optimization procedure is presented. In the next step, the model is implemented into a case study for evaluation purpose. Results show that the proposed model has a good convergence rate to the existing models and is capable of generating accurate solutions.

This report presents the results of 10 full-scale fire resistance tests conducted at the National Fire Laboratory on load-bearing gypsum board protected, wood stud shear wall assemblies with and without resilient channels on the fire-exposed side. The two assembly arrangements studied were: symmetrical installation 1x1 (one layer of gypsum board on each of the exposed and unexposed sides) and asymmetrical installation of the shear membrane (one layer of gypsum board on both the exposed and unexposed sides and a shear wall membrane as a base layer alternating between the exposed (2x1) and unexposed sides (1x2)) on a wood stud frame. The gypsum board was 12.7 mm thick Type X. The insulations used were glass and rock fibres. The shear membranes used were plywood and oriented strand board (OSB).

The IEA examines the full spectrum of energy issues including oil, gas and coal supply and demand, renewable energy technologies, electricity markets, energy efficiency, access to energy, demand side management and much more. Through its work, the IEA advocates policies that will enhance the reliability, affordability and sustainability of energy in its 30 member countries, 7 association countries and beyond.

This paper provides estimates of labour productivity levels in OECD manufacturing, for 9 countries and 36 industrial sectors. It also provides an overview of some of the available evidence on cross-country productivity differences in the service sector. The paper uses industry-specific conversion factors to calculate productivity levels, based on available industry-of-origin studies and material from the expenditure approach to international comparisons. After a discussion of some methodological issues, the paper describes the estimation of manufacturing productivity levels in detail, while also referring to some other recent work on the issue. The variation in cross-country productivity levels appears to be quite large in the OECD area, suggesting that there may be scope for further productivity catch-up in many countries and many sectors.