Design Development and Evaluation of Topical Microemulsion

Microemulsion as an novel approach for topical administration of medicament or drug. Microemulsion can be formulated by using oil phase,aqueousphase,surfactant and cosurfactant by using psudeo ternary phase digram. The advantage of this microemulsion system having ease manufacturing , spontaneous formation,having thermodynamic stability and hydrophobic drug can be easily formulated or incorparted in to miceoemulsion base .When this microemulsion are combined with gel system are called emulgel.This microemulsiom based gel having better stability,dual control relase system.Gel based become non greasy,emollient and more patient compliance.Now a day various polymers are used as gelling agent it make help to reduce the interfacial tension of oil and aqueous phase of microemulsion and also increasing the viscosity aqueous phase.This approach of emulgel drug delivery used for fungal disorder of skin and also artheriitiscondition.this review gives complete knowledge of miceroemulsion, formulation consideration,properties,advantages and application.

2021

Abstract: A drug delivery method has been explored as microelectric emulsions that are optically isotropical, and thermodynamically stable water, oil, surfactant and/or surfactants due to their potential to solubilize poorly water soluble medicines and to their increased topical and systemic availability. The lipophilic drugs mobility may be solubilized and the skin can be entered quickly and effectively. Thus the topical administration of drugs is helpful. Many commonly utilized topical treatments such as salts, creams and lotions have numerous drawbacks such as sticky texture, causing discomfort when applied, They have a lower coefficient of propagation so applied by rubbing and they also show a stability concern. The difficulty of stability of the microemulsion is low viscosity, but it may be solved by adding viscosity and the moisturizing stratum corneum into topical DDS, which increases dermal penetration and skin flow of medical devices. Because of all these considerations, th...

International Journal of Pharmaceutical Sciences and Medicine (IJPSM), 2024

A topical drug delivery system usually denotes local dermatological activity as the effect of the pharmaceutical component on the skin to cure the disease. The microemulgel can be used to achieve a combined effect of microemulsion and gel. It shows the dual control release effect of drugs and increasing stability. It has the primary objective ability to incorporate hydrophobic drugs. Various market products containing foreign agent, for example gel, cream, ointment they have several drawbacks, including poor absorption, poor permeability, allergic reaction, irritation, less spreading stickiness, and stability problem. This evaluation provides a summary of the best properties, excipient, preparation, and evaluation related to microemulgel. A recent study of recent development and future directions for microemulgel-based systems was conducted. The emulgel provides various beneficial aspects of its cosmetic and dermatology activity, thixotropic, greaseless, emollient, easily distributed, readily removable, non-staining and water-soluble, with a long half-life, biocompatible, and transparent and pleasant appearing. Therefore, emulgel is a better semi-solid preparation neither conventional system nowadays. It is utilized to administer of anti-inflammatory, anti-fungal, anti-acne, analgesic, anti-psoriasis drugs. The formulated emulgel is characterized of various parameters such as pH, viscosity, spreadability, etc. its need and merit will advance in the upcoming years.

2021

Background: Microemulsion is one of the promising sub-micron carriers for topical drug delivery as it offers advantages like high drug-loading capacity and good skin penetration. Microemulsion based gel of posaconazole (broad-spectrum antifungal agent) could be an effective strategy for treatment of topical fungal infections. Objective: To develop microemulsion based hydrogel of posaconazole was for effective treatment of skin mycosis. Methods: Optimized microemulsion batches were selected through pseudoternary phase diagram (using oleic acid, tween 80 and IPA as oil, surfactant and co-surfactant, respectively) followed by stability studies and characterization. Results: The drug content and pH were found in the desired range. The droplet size of optimized formulations were found within the desired range (<200nm). The hydrogel prepared (from selected microemulsion batches) were found to have good spreadability and texture (adequate adherence). The in-vitro and ex-vivo studies exh...

Biosciences Biotechnology Research Asia

Microemulsions (ME) is a system that combines water, oil, and an emulsifier / surfactant which is a form of volatile liquid, homogeneous and kinetically stable. Microemulsion is an attractive drug delivery system for topical administration. Due to its solubility, mild skin irritation, and watery swelling are used in the Topical Drug Delivery System (TDDS). By improving the quality of skin texture, it provides a level of penetration. The function of skin balance is to limit the penetration of bacteria, viruses, and other environmental factors. With standard drugs, skin penetration may take time and have not been able to provide immediate action. So, in this case, we used the Microemulsion-based Topical Drug Delivery system. Microemulsion increases solubility, protects the drug from environmental factors and improves drug bioavailability. MEs provide high penetration and the ability to penetrate into the skin. Because of this, the immediate action of the drug can occur in the infected...

International Journal of Applied Pharmaceutics

Objective: The present research was aimed to develop ketoconazole (KT) loaded microemulsion-based gel formulation for effective topical delivery through enhanced drug solubility, improved skin permeation and reduced side effects overcoming drawbacks of conventional dosage forms. Methods: For the selection of oil, surfactant and co-surfactant mixture (Smix) ratio, the phase titration method was used and pseudo-ternary phase diagrams were prepared. D-optimal mixture design was employed to optimize the microemulsion system taking oil, Smix and water as independent variables and particle size, polydispersity index, zeta potential, % transmittance and cumulative % drug release as response variables. Finally, topical gel formulation of KT-loaded microemulsion was developed and evaluated for physico-chemical properties, rheological properties, in vitro drug release kinetics and ex-vivo drug permeation. Results: The optimized microemulsion was found to be a transparent formulation with 19.7...

2019

Microemulsion is an best candidates as novel drug drlivery system because of their shelf life and improve the drug solubilization with easy of preparation and administration. The term microemulsion refers to thermodynamically stable iostropically dispersion of two immisible liquid such as oil and water stabilized by interfacial film of surfactant molecule. Now a days microemulsion is an emerging trade and having worldwide importance in varity of technological application .These application include enhanced oil recovery,cosmeceuticals agriculture ,metal cutting,organic and bio organic reaction. Monali B. Lalage | Sujit Kakade | Ashok Bhosale "Review on Microemulsion a Novel Approach for Antifungal Drug Delivery" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29759.pdf

International Journal of Pharmaceutical Sciences Review and Research, 2014

The aim of present study was to develop micro emulsion system for topical application of miconazole to provide various advantages over conventional dosage forms. Miconazole nitrate is hydrophobic imidazole antifungal agent. Clinical studies show that it is highly effective for topical treatment of fungal infections. Micro emulsion was prepared using oleic acid as an oil phase, tween 20 as surfactant and propylene glycol as co-surfactant. In vitro characterization of micro emulsion of miconazole nitrate was done through measurement of pH, conductivity, viscosity, antifungal activity, drug release kinetics. Miconazole nitrate cream (2%) was used as reference sample for comparison of antifungal activity and release rate. The data obtained from various studies gave satisfactory results. Micro emulsion showed greater antifungal activity against Candida albicans as compared to reference sample. In vitro drug release studies were conducted for micro emulsion and reference sample using Franz diffusion cell. Faster drug release rates were observed for micro emulsion formulation than reference sample. Drug penetration from micro emulsion followed Higuchi model whereas drug release from reference formulation followed Korsmeyer-Peppas model. It was concluded that miconazole nitrate can be formulated as micro emulsion with good release and consistency.

A fluconazole w/o microemulsion was developed for topical application using isopropyl myristate as the oil phase. Pseudo-ternaryphase diagrams were constructed to determine the microemulsion existence region using surfactant (tween 80) andco-surfactant (polyethylene glycol 400). Different formulations were prepared to evaluate the effect of oil content, surfactant/co-surfactant concentration on in-vitro permeation rates. In-vitro transdermal permeability of fluconazole from themicroemulsions was evaluated using Keshary Chien diffusion cells mounted with 0.45µ cellulose acetate membrane. Theamount of fluconazole permeated was analyzed by HPLC. The permeability of the fluconazole incorporated into themicroemulsion systems was 2.5 - fold higher than that of the marketed formulation. These results indicate that the microemulsionsystem studied is a promising tool for the percutaneous delivery of fluconazole.

Biomedicine & Pharmacotherapy, 2018

Microemulsions are thermodynamically stable, transparent, colloidal drug carrier system extensively used by the scientists for effective drug delivery across the skin. It is a spontaneous isotropic mixture of lipophilic and hydrophilic substances stabilized by suitable surfactant and co-surfactant. The easy fabrication, long-term stability, enhanced solubilization, biocompatibility, skin-friendly appearance and affinity for both the hydrophilic and lipophilic drug substances make it superior for skin drug delivery over the other carrier systems. The topical administration of most of the active compounds is impaired by limited skin permeability due to the presence of skin barriers. In this sequence, the microemulsion represents a cost-effective and convenient drug carrier system which successfully delivers the drug to and across the skin. In the present review work, we compiled various attempts made in last 20 years, utilizing the microemulsion for dermal and transdermal delivery of various drugs. The review emphasizes the potency of microemulsion for topical and transdermal drug delivery and its effect on drug permeability.