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木贼对动脉粥样硬化早期大鼠血清IL-1、IL-8及TNF-α的影响

木贼对动脉粥样硬化早期大鼠血清IL-1、IL-8及TNF-α的影响

2003
Giuseppe Confessore
Abstract
目的观察木贼对大鼠动脉粥样硬化早期血脂及血清IL-1、IL-8、TNF-α的影响.方法高脂饲料复制SD大鼠高脂血症和早期动脉粥样硬化模型,同时给以不同剂量木贼水煎剂灌胃,实验10 w后,测定各组动物血脂水平及血清IL-1、IL-8、TNF-α含量.结果木贼预防性用药后与模型组比较血脂降低(P＜0.01),血清中IL-8明显减少(P＜0.01),高剂量给药还可降低血清IL-1含量(P＜0.01).结论木贼预防性用药可调控血清中炎性细胞因子IL-1 、IL-8的含量,有延缓动脉粥样硬化病变形成的作用.

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