Effect of Euthyroid Nodular Goiter on Anxiety and Depression

AYDIN SAĞLIK DERGİSİ

2012

Aim: Different proteins have different roles in various diseases. Argyrophilic nucleolar organising region associated proteins (AgNORs) are synthesized from secondary constriction of acrocentric chromosome interested in a variety of diseases including thyroid disorders. Our aim was the comparison of the AgNOR count and AgNOR surface area/total nuclear surface area (NORa/TNa) proportions to different sex and age in cases with cystic nodular goitre. Materials and Methods: Twenty female (age range 26-78) and male (age range 2679) whose fine needle aspiration (FNA) materials were compatible with cystic nodular goitre were included in the study. Those biopsy materials were stained for AgNOR detection according to a specific protocol. 100 nuclei per individual have been evaluated, and both AgNOR count and NORa/TNa values of individual cells were detected for each group. Results: Female patients with cystic nodular goitre had not significantly (p=0.131) higher AgNOR count (2.05±0.46%) and ...

Eskisehir Medical Journal, Eskisehir City Hospital

Hypothyroidism is one of the common diseases worldwide that occurs when the thyroid gland is unable to produce enough thyroid hormone for the body's metabolic needs. Thyroid hormones play a critical role in the metabolic activity of the brain, and hypothyroidism has important effects on neuropsychiatric function. The incidence of depressive syndrome is higher in patients with hypothyroidism. However, the mechanism of depression and other psychiatric disorders caused by hypothyroidism is stil unclear. The symptomatic manifestations of depression are diverse and it is possible to model many of them in experimental animal models. Studies have shown that hypothyroid animals are more likely to develop depression like behaviors when compared to euthyroid controls. In these studies, a much longer immobility time was observed in the forced swim test in hypothyroid rats. It has been suggested that neurotransmitter systems in the brain, especially serotonin, are involved in the mechanism ...

DergiPark (Istanbul University), 2013

Bu çalışma, allojenik ve otolog kök hücre nakli (KHN) yapılan hastaların anksiyete ve depresyon düzeyinin belirlenmesi amacıyla tanımlayıcı olarak yapılmıştır. Örneklemi toplam 60 hasta oluşturmuştur. Çalışmada araştırmacı tarafından soru formu geliştirilmiştir. Hastane Anksiyete ve Depresyon Ölçeği (HADÖ) araştırma formuyla karşılaştırmak için kullanılmıştır. Otolog gruptaki hastaların hastaneye yatış ve 30. gün anksiyete düzeyi allojenik gruptan daha yüksek saptanmıştır. Anksiyete düzeyleri açısından 2 grup arasındaki fark istatistiksel olarak anlamlı bulunmuştur (p<0,05). Çalışmada hastaların yaş, tanı, eğitim, cinsiyet, medeni durum, fizyolojik sorunlara göre anksiyete ve depresyon sorunları karşılaştırılmıştır. Hastalardan aplastik anemili hastaların anksiyete düzeyi daha yüksek saptanmıştır. Diğer yandan allojenik KHN yapılan bayan hastalarda depresyon düzeyi daha yüksek olarak belirlenmiştir. 2 grup arasındaki fark istatistiksel olarak anlamlı bulunmuştur (p<0.05).

Dicle Medical Journal, 2012

Objectives: Fine-needle aspiration biopsy (FNAB) is the gold standard in the management of thyroid nodules and specimen should be obtained from dominant nodule. In our study, we aimed to compare the FNAB and histopathology results of dominant and non-dominant nodules and to evaluate the association between nodule size and histopathology results in patients with MNG. Materials and methods: Between 2009 and 2010, 197 cases who had diagnosed MNG were analyzed. These cases were performed FNAB from both dominant nodule and non-dominant nodule. 26 patients with inadequate cytological results were excluded and 171 cases were included in the analysis. Malignant ultrasonographic (US) features were defined as showing marked hypoechogenicity, microcalcifications, solid structure and not having peripheral halo. Results: No statistically significant difference was observed between malign cytology and suspected cytology ratios of dominant nodules and non-dominant nodules (p=0.083). Malignancy rates were higher at dominant nodules not having peripheral halo and non-dominant nodules including microcalcification at US. Also statistically significant difference was not observed (p=0.485) between malign histopathology rates of dominant and non-dominant nodules after surgery. Conclusions: According to cytological and histopathological results of patients with MNG, there was no significant difference between the malignancy ratio of dominant and non-dominant nodules. There is no obvious correlation between malignancy and nodule size in patients with MNG. We think that FNAB obtained not from only dominant nodules but also nodules with suspicious features of malignancy is necessary for most accurate diagnosis.

19.Ulusal Psikoloji Kongresi, 2016

Ortadoğu Tıp Dergisi, 2017

Öz Amaç: Toplumda sık görülen kronik otitis media ve anksiyete/depresyon ilişkisini ortaya koymayı amaçladık. Gereç ve Yöntem: Çalışmaya ileri işitme kaybı ve tinnitusu olmayan kronik otitis media'lı 50 erkek ve 50 kadın ile kontrol grubu olarak da 25 erkek ve 25 kadın alındı. Erkek ve kadınlar kendi aralarında değerlendirildi. Grup 1 kontrol grubu grup 2 ise kronik otitli hastalar olarak değerlendirildi. Değerlendirme Beck anksiyete (BAS)/depresyon (BDS) skalaları ile yapıldı. Bulgular: Erkek cinsiyet için grup 1 de BDS' den alınan ortalama skor 11.37±6.3grup 2'de 19,50±2,82 olarak saptandı (p<0.05). Grup 1 BAS'dan alınan ortalama skor 12,33±6,23 grup 2'de 15,69±24,73 olarak saptandı (p<0.05). Kadın cinsiyet için grup 1 de BDS'den alınan ortalama skor 10,42±9,13 grup 2'de 19,14±2,12 olarak saptandı (p<0.05). Grup 1 BAS'dan alınan ortalama skor 11,64 ±5,66 grup 2'de 18,25±9,69olarak saptandı (p<0.05). Her iki cinsiyette de hem BDS hem de BAS'dan alınan ortalama skorlar grup 2'de grup 1'e göre istatiksel olarak anlamlı oranda yüksek saptandı. Tartışma: Çalışmamızda kronik otitis media hastalarında anksiyete ve depresyon yüksek oranda görüldüğünü belirledik. Literatür incelemelerinde kronik otitis medianın işitme kaybı ve tinnitus gibi birçok semptomu ile yaşam kaliteleri ve anksiyete/depresyon ilişkilerini inceleyen çalışmalar olmasına rağmen pür kronik otitis media ve anksiyete/ depresyon ilişkisini incelediğimiz çalışmamızın bu konuda yapılmış ilk çalışma olduğunu düşünmekteyiz. Sonuç: Kronik otitis medialı hastaların takibinde, bu hastalığın anksiyete ve depresyon ile ilişkili olabileceği de dikkate alınmalıdır.

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi, 2020

Thyroid nodule refers to lesions originating from follicular cells and radiologically differentiated from thyroid parenchyma. It is more common in women and its frequency increases with age. In Ultrasonography (USG) scans, nodules are detected in 20-67% in thyroid. Carcinoma develops from 7-15% of thyroid nodules. TSH should be seen from patients with thyroid nodules and thyroid USG should be requested. FNA should be requested from patients according to thyroid USG features. Thyroid FNA results are evaluated according to the Bethesda classification. Treatment for nodule is planned according to Fine needle Aspiration biopsy (FNAB) results, clinical features of the patient, USG findings and molecular tests. In this article, the approach to thyroid nodule is discussed with current literature.

Üsküdar University, 2019

As with other diseases, the examination of genetic factors for the diagnosis and treatment of psychological diseases is an important issue. Monoamine oxidase (MAO) enzyme plays an important role in the etiology of various neurological diseases. Therefore, the examination of the gene group which encoding the MAO enzyme has an important role in the research of neuropsychology and clinical psychology. Monoamine oxidase A (MAOA), a regulator of monoamine neurotransmitters in the brain, has been one of the most prominent genes in gene-environment interaction studies, especially with regard to central nervous system disorders. Depression is one of the mood disorders mentioned in this thesis. There is a long period of time, where the person is severely depressed, rather than a bad emotional state or sadness. Anxiety with other mood disorders is accompanied by psychological problems and is a fundamental disorder at the root of many psychopathological forms. Anxiety within the normal range serves as an activating feeling for the individual, while an abnormal level of anxiety disturbs the personal, social, academic or professional functioning of the individual. This mood disorder causes the person to move away from his / her social environment and this leads to the inability to control of emotional changes. Our finding here (our hypothesis) is to find a genetic marker that governs the criteria for psychology for depression and anxiety from those who are in a state of state of affairs. The candidate polymorphic gene region for this pilot study is the MAOA isoform. We used the universally accepted back depression and anxiety scale for the emergence of mood disorders. Our hypothesis is to gain significance between MAOA and depression and anxiety. MAOA-VNTR gene and Back Depression and Back Anxiety scale tests. The selected population is a group of 102 people composed of individuals aged 18-25 years. Due to the location of the selected gene region in the chromosome, the population is divided into two groups based on gender. According to the statistical analysis, the results of back-depression and back-anxiety tests and the results of genetic diagnosis are obtained in male subjects whereas in women, no significant results could be obtained.