Microemulgel: a novel approach for topical drug delivery

International Journal of Pharmaceutical Sciences and Medicine (IJPSM), 2024

A topical drug delivery system usually denotes local dermatological activity as the effect of the pharmaceutical component on the skin to cure the disease. The microemulgel can be used to achieve a combined effect of microemulsion and gel. It shows the dual control release effect of drugs and increasing stability. It has the primary objective ability to incorporate hydrophobic drugs. Various market products containing foreign agent, for example gel, cream, ointment they have several drawbacks, including poor absorption, poor permeability, allergic reaction, irritation, less spreading stickiness, and stability problem. This evaluation provides a summary of the best properties, excipient, preparation, and evaluation related to microemulgel. A recent study of recent development and future directions for microemulgel-based systems was conducted. The emulgel provides various beneficial aspects of its cosmetic and dermatology activity, thixotropic, greaseless, emollient, easily distributed, readily removable, non-staining and water-soluble, with a long half-life, biocompatible, and transparent and pleasant appearing. Therefore, emulgel is a better semi-solid preparation neither conventional system nowadays. It is utilized to administer of anti-inflammatory, anti-fungal, anti-acne, analgesic, anti-psoriasis drugs. The formulated emulgel is characterized of various parameters such as pH, viscosity, spreadability, etc. its need and merit will advance in the upcoming years.

ChemInform, 2014

Topical delivery systems for drugs make localized administration of the drug anywhere in the body through ophthalmic, vaginal, skin and rectal routes. Topical formulations encompass a wide variety of formulations intended for cosmetic or dermatological application, to healthy as well as diseased skin. Drugs may be administered for localized or systemic effect. Topical preparations can be formulated with varying physico-chemical properties, as solid, semisolid or liquid. Microemulsion of drug is prepared and incorporated into emulgel, having novel topical drug delivery system as dual release control system. Micro-emulsions are micronized; thermodynamically stable systems having low interfacial tension prepared by adding co-surfactant have several features like enhanced permeability, good thermodynemic stability and prolong release. Emulgel prolongs the drug release, increases patient compliance and stability of emulsion. The prepared emulgel is evaluated for various parameteres like pH, viscosity, globule size; spreadability etc. whereas micro-emulsion is evaluated for various parameters like viscosity, pH, zeta-potential etc.

Microemulsion as an novel approach for topical administration of medicament or drug. Microemulsion can be formulated by using oil phase,aqueousphase,surfactant and cosurfactant by using psudeo ternary phase digram. The advantage of this microemulsion system having ease manufacturing , spontaneous formation,having thermodynamic stability and hydrophobic drug can be easily formulated or incorparted in to miceoemulsion base .When this microemulsion are combined with gel system are called emulgel.This microemulsiom based gel having better stability,dual control relase system.Gel based become non greasy,emollient and more patient compliance.Now a day various polymers are used as gelling agent it make help to reduce the interfacial tension of oil and aqueous phase of microemulsion and also increasing the viscosity aqueous phase.This approach of emulgel drug delivery used for fungal disorder of skin and also artheriitiscondition.this review gives complete knowledge of miceroemulsion, formulation consideration,properties,advantages and application.

Transparent or translucent semisolid formulations are called as Topical Gels and through rectal, vaginal, ophthalmic and skin as topical route are used for localized drug delivery. Different methods are used to enhancement of permeability and bioavailability of topical gels that can be incorporate into a novel drug delivery system like emulgel, solid dispersion into gel, hydrogel, microemulsion gel, solid lipid nanoparticles into gel, liposomal gel. The major limitation of Hydrogel is in the delivery of hydrophobic drugs. Therefore, Microemulsion based hydrogel approach is being used so that even a hydrophobic therapeutic moiety can be delivered efficiently as hydrogels. This review is concerned with all detail information regarding novel approach to microemulsion based hydrogel formulations, advantages and disadvantages, classification, basic components of topical drug delivery systems, method of preparation, available marketed preparations and evaluation of microemulsion based hydrogels and mainly highlights the novel approach of formulation.

2021

Abstract: A drug delivery method has been explored as microelectric emulsions that are optically isotropical, and thermodynamically stable water, oil, surfactant and/or surfactants due to their potential to solubilize poorly water soluble medicines and to their increased topical and systemic availability. The lipophilic drugs mobility may be solubilized and the skin can be entered quickly and effectively. Thus the topical administration of drugs is helpful. Many commonly utilized topical treatments such as salts, creams and lotions have numerous drawbacks such as sticky texture, causing discomfort when applied, They have a lower coefficient of propagation so applied by rubbing and they also show a stability concern. The difficulty of stability of the microemulsion is low viscosity, but it may be solved by adding viscosity and the moisturizing stratum corneum into topical DDS, which increases dermal penetration and skin flow of medical devices. Because of all these considerations, th...

International Journal of Research in Pharmaceutical Sciences, 2020

A huge amount of Indian medicinal plants are accredited with various pharmacological activities. Extract of medicinal plant and extracted oil have more or less pharmacological property, some natural penetration enhancers have advantages such as low cost, better safety profile hence they increase their acceptances in the formulation of microemulgel. Some of oil may assist the therapeutic action of API. It is convenient, cost-effective to use of herbal oil as oil phase or API, penetration enhancer, surfactant or other constituent in microemulgel formulation. Microemulgel is a microemulsion and gel combination with herbal ingredient, with small sized globule present in an emulsion. Microemulsion consists of delivering a drug dissolved in a mixture of one or more excipient like mono, di, and triglycerides, lipophilic and hydrophilic co surfactant. Microemulsion is formed when entropy changes in that dispersion is greater than the free energy require increasing the surface area between ...

Biosciences Biotechnology Research Asia

Microemulsions (ME) is a system that combines water, oil, and an emulsifier / surfactant which is a form of volatile liquid, homogeneous and kinetically stable. Microemulsion is an attractive drug delivery system for topical administration. Due to its solubility, mild skin irritation, and watery swelling are used in the Topical Drug Delivery System (TDDS). By improving the quality of skin texture, it provides a level of penetration. The function of skin balance is to limit the penetration of bacteria, viruses, and other environmental factors. With standard drugs, skin penetration may take time and have not been able to provide immediate action. So, in this case, we used the Microemulsion-based Topical Drug Delivery system. Microemulsion increases solubility, protects the drug from environmental factors and improves drug bioavailability. MEs provide high penetration and the ability to penetrate into the skin. Because of this, the immediate action of the drug can occur in the infected...

Saudi Pharmaceutical Journal, 2016

As compared to gel and other topical preparations microemulgel has been prepared by screening of oils, emulsifier, and co-emulsifier on bases of solubility of an API in it. An API has high solubility and oil may also have more or less pharmacological property, so it may assist the therapeutic action of API. Due to presence of oil portion, it leads to more penetration of API in the skin. Oil Micelle Size was less than 500 nm which provides more area for absorption of API in the skin so more penetration and more effective than macro-emulsion. Microemulgel has an advantage of emulgel that has dual benefits of micro-emulsion and gel and several other desirable properties like good consistency, thyrotrophic, greaseless, easily spreadable as well as removable, emollient, nonstaining, water soluble, longer shelf-life, bio-friendly, transparent, pleasant appearance, ability of patients for self-medication, termination of medications will be easy, etc.

International Research Journal of Pharmacy

A microemulsion based gel was designed for the topical and targeted delivery of sertaconazole nitrate for the treatment of su perficial fungal infection. The microemulsion region was obtained using a ternary diagram, different ratio of oil and Smix were used. The microemulsion of sertaconazole containing 2% (w/w) of sertaconazole, 6.67% (w/w) of oil phase (Eugenol+Oleic acid 1:1), 60.18% (w/w) of surfactant mixture 2:1 ratio (Tween-80 and Transcutol-P) and 33.15% (w/w) with distilled water. The prepared microemulsion gel and commercial cream of sertaconazole were evaluated for in-vitro and ex-vivo studies. The highest drug retention was achieved with Tween 80 and Transcutol P (T80TC45) when the optimized formulation was converted to a gel. The designed formulation MG2 was safe to be used over the skin as the PDI=0 when compared with commercial cream and MG1. The optimized formulation also posse's anti-inflammatory activity. The average zone of inhibition of MG2 was (23.19 ± 0.478) which was more than the commercial cream (15.34 ± 0.382) or MG1 (17.78 ± 0.715). Candida albicans which may be due to better permeation and retention effect of microemulsion gel 2. The MG2 was found to be stable after six month. The results obtained in this research from in vitro and in vivo data it can be concluded that the developed microemulsions have great potential for topical drug delivery in the treatment of inflammation and fungal infection.

Biomedicine & Pharmacotherapy, 2018

Microemulsions are thermodynamically stable, transparent, colloidal drug carrier system extensively used by the scientists for effective drug delivery across the skin. It is a spontaneous isotropic mixture of lipophilic and hydrophilic substances stabilized by suitable surfactant and co-surfactant. The easy fabrication, long-term stability, enhanced solubilization, biocompatibility, skin-friendly appearance and affinity for both the hydrophilic and lipophilic drug substances make it superior for skin drug delivery over the other carrier systems. The topical administration of most of the active compounds is impaired by limited skin permeability due to the presence of skin barriers. In this sequence, the microemulsion represents a cost-effective and convenient drug carrier system which successfully delivers the drug to and across the skin. In the present review work, we compiled various attempts made in last 20 years, utilizing the microemulsion for dermal and transdermal delivery of various drugs. The review emphasizes the potency of microemulsion for topical and transdermal drug delivery and its effect on drug permeability.