At What Age Threshold does the Decline in Semen Parameters Begin?

2021

Aim: To investigate the effect of increasing male age on the semen parameters including semen volume, sperm concentration, and progressive sperm motility. Materials and Methods: 1038 patients who applied to our IVF clinic for semen analysis or for infertility treatment were included in the study. The participants were divided into three age categories as follows: 680 participants (65.5%) aged 22-30, 139 participants (13.4%) aged 31-45 years, and 219 participants (21.1%) aged ≥45 years. Demographic and baseline clinical characteristics were recorded. The variables considered in this study were age and the following semen parameters: volume (ml); sperm concentration (millions/ml); and progressive sperm motility A+B (%). Normal semen values were defined based on the WHO criteria (World Health Organization, 2010). Results: The mean age of the participants was 33.1(± 4.8). The mean BMI of the participants was 24.1(± 2.8). The mean semen volume was 3.3 (± 1.5), the mean semen concentratio...

Andrologia, 2007

Male age-semen parameters-sperm quality Correspondence Eliahu Levitas, MD, Fertility and IVF Unit,

Fertility and Sterility, 2010

Objective: To compare the semen quality and age-specific changes in men between the 1980s and 2000s. Design: Prospective study. Setting: Andrology laboratory, University of Calcutta, India. Patient(s): A semen sample was obtained from 3729 men presenting for infertility problems in two distinct decades, that is, between 1981-85 and 2000-2006. Intervention(s): Subjects with sperm count >20 Â 10 6 /mL without any extreme pathological disorders were selected. Samples having a major liquefaction problem were excluded. Main Outcome Measure(s): A standard World Health Organization procedure for semen analysis was performed that included assessment of volume, sperm concentration, and percentage motility. The motility parameters were further classified into forward progressive motility and nonprogressive motility.

Human Reproduction, 2003

BACKGROUND: Although the effect of maternal age on fertility is well known, it is unclear whether paternal age also affects fertility. This cross-sectional study sought to characterize the association between age and semen quality, a well-known proxy of fertility status. METHODS: A convenience sample of 97 non-smoking men (aged 22-80 years) without known fertility problems was recruited from a national

Andrology-Open Access, 2013

Background: The contributions of host factors, such as age, in male infertility are still poorly understood. Thus, the present work has aimed to evaluate the effect of patient's age on semen parameters of infertile males. Method: Semen samples from 52 infertile patients aged 21-52 years (mean 30.8 ± 6.7) were analysed by conventional semen analysis methods, flowcytometry analysis for sperm DNA integrity, and colorimetric assay for total antioxidant capacity. Results: The study revealed that, as patient's age increases, there was a significant reductionin sperm density, motility, percentage of morphologically normal spermatozoa, total antioxidant capacity and DNA integrity. Conclusion: The study results demonstrated the negative influence of increasing patient's age on semen parameters; and the possible role of patient's age in the aetiology of male infertility.

Cureus

Introduction: Male infertility contributes to a significant proportion of infertility cases, and advanced paternal age has been suggested to affect semen quality and fertility. However, the relationship between age and semen quality remains inconclusive, with conflicting findings reported in the literature. This study aimed to investigate the effect of age on semen quality among male partners of infertile couples in a tertiary care center in eastern India. Methods: A cross-sectional observational study was conducted, involving 390 male participants aged 21-50 years, who were referred to the andrology laboratory for semen analysis between January 2019 and December 2022. Participants were categorized into three age groups (21-30, 31-40, and 41-50 years). Semen parameters, including sperm concentration, semen volume, motility, and morphology, were assessed according to the World Health Organization guidelines. Results: Among the participants, no significant differences were observed in semen volume, motility, and morphology across different age groups. However, a statistically significant difference in sperm concentration among the three age groups was observed (p = 0.022). Spearman correlation analysis revealed a positive correlation between age and sperm concentration (r = 0.124, p = 0.013) as well as total sperm count (r = 0.10, p = 0.049). Conclusion: In this study, no significant decline in semen quality with age was found among male partners of infertile couples aged 21-50 years. These findings highlight the complex relationship between age and semen quality and emphasize the need for further research to better understand the underlying mechanisms and provide more conclusive evidence regarding the impact of age on male fertility.

Journal of Andrology, 2006

The most widely used reference values for human semen and sperm variables were developed by the World Health Organization (WHO) to help assess the fertility status of men interested in reproduction (typically a younger population). In this retrospective analysis, data from a large population of men aged 45 years or older were analyzed to derive semen and sperm reference ranges for an older population. Baseline semen samples were obtained from 1174 men with no or mild erectile dysfunction (ED) during the screening phase of two clinical trials evaluating the effects of a drug on human spermatogenesis. The median values and 95% reference ranges for 4 measured semen and sperm parameters (semen volume, sperm concentration, sperm motility, and sperm morphology) and 1 derived parameter (total sperm count) were calculated for the population and by age quartile. These references ranges were compared to established WHO reference values. Associations between the semen and sperm parameters and smoking status, alcohol use, and serum hormone concentrations were also analyzed. The mean age was 52.9 years (range: 45-80). Median semen volume, sperm motility, and sperm morphology parameters declined significantly with age. Only 46% of study subjects had baseline values for semen and sperm parameters that met or surpassed all the WHO reference values. This is the first study to statistically derive semen reference ranges from a large population of men aged 45 years or older. The observation that less than half the men in this study met all 4 WHO reference values for measured semen and sperm parameters underscores the need for age-specific reference ranges.

JBRA Assisted Reproduction, 2014

Objective: The aim of this study was to evaluate the effects of aging on semen quality in a population of infertile couples. Methods: A cross-sectional study of semen samples obtained from 1,500 men randomly selected from couples who attended an infertility clinic was conducted. The analyses were performed using Spearman's correlation and Mann-Whitney tests. The age groups consisted of men ≤ 35 years, from 36-45 years and > 45 years of age. The semen analysis was performed according to the WHO criteria, and morphology was evaluated using the motile sperm organelle morphology examination (MSOME). The percentages of normal spermatozoa and spermatozoa with large nuclear vacuoles (LNV, occupying > 50% nuclear area) were determined. The percentages of DNA fragmentation were assessed using the TUNEL assay. Results: A regression analysis revealed that the percentages of LNV spermatozoa and sperm DNA fragmentation positively correlated with age. Conversely, a regression analysis revealed that the percentage of normal sperm, sperm progressive motility and sperm vitality negatively correlated with age. As in the previous test, the analysis by age group showed that there was a significant reduction (P < 0.05) in the percentage of normal sperm, sperm progressive motility and sperm vitality as age increased. Conversely, the percentage of spermatozoa with LNVs and sperm DNA fragmentation significantly increased (P < 0.05) as age increased. Conclusion: Semen quality seems to be influenced by aging. The age-related decrease in sperm quality suggests that delaying childbearing, not only for women but also for men, may jeopardize reproductive capacity.

Fertility and Sterility, 2018

Objective: To assess the impact of aging on routine semen and computer-assisted sperm analysis (CASA) motility parameters according to the current World Health Organization guidelines; and to evaluate the effect of obesity and lifestyle (alcohol consumption, cigarette smoking) in older men's semen.

Objective: Sperm motility is one of the most important factor in fertility of men. Because, it describes the ability of sperm to move properly through the female reproductive tract and reach the egg in order to fertilize it. Various factors, such as semen quality and other parameters are known to be effect on sperm motility. This study was designed to determine, how semen parameters and individuals age infl uence on sperm motility. Method: Samples were collected from 273 men undergoing evaluation and treatment for infertility in Infertility Treatment Center, ACECR branch of Qazvin, Qazvin, Iran. Semen analysis was performed according to World Health Organization (WHO) criteria. In this procedure we considered on determination of sample volume, sperm concentration, motility, normal morphology and liquefaction time. Results: In this analysis, our results showed, increasing in sperm count, sample volume and normal morphology increased sperm motility signifi cantly. In contrast, increasing in liquefaction time and age decreased sperm motility signifi cantly. Our statistical analysis demonstrated that sperm concentration and semen volume have the most and lowest effect on motility respectively. Conclusion: In our study, semen parameters tend to have an infl uence on sperm motility.