Optic nerve incidentaloma
Eric SiglerOphthalmology at Point of Care
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Abstract
Retinal astrocytic hamartomas are rare, benign tumors of glial origin. These lesions are often associated with systemic syndromes, including tuberous sclerosis complex and neurofibromatosis type 1, but also may be encountered in otherwise healthy individuals as an acquired lesion. We present the following case to illustrate clinical and imaging characteristics typically seen in astrocytic hamartoma found as “optic nerve incidentaloma” in an otherwise healthy teenager.
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International …, 2001
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Bilateral Optic Malignant Astrocytoma in a 3 Year Old Child with Nfi – Case Presentation
2009
INTRODUCTION Neurofibromatosis type 1(NF I) is a common autosomal dominant condition that affects about 1 in 5000 people. Optic nerve glioma is one of the landmark lesions characterizing this disease. They usually occur in children during the first decade of life and are seen in 11–30% of patients with NF I. When associated with NF1, the tumors are more often benign, can be multifocal and bilateral, and are usually found within the optic nerves although they can occur anywhere along the optic pathway, all the way to the visual cortex. Although the unilateral occurrence is a finding quite common in this population (up to 30%) bilateral involvement of the optic nerves is rare. Further, the optic gliomas in NF1 are self-limiting lesions with a very slow growth (which stops in adolescence). As a result exophtalmus is a very rare finding and they require surgical intervention in a very small number of cases.
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IntechOpen, 2018
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Ophthalmic Genetics, 2008
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American Journal of Ophthalmology, 1980
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Infrared Imaging and Optical Coherence Tomography Reveal Early-Stage Astrocytic Hamartomas Not Detectable by Fundoscopy
American Journal of Ophthalmology, 2012
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Glial tumors of the retina. The 2009 King Khaled Memorial Lecture
Saudi Journal of Ophthalmology, 2009
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Combined hamartoma of the retina and retinal pigment epithelium is a rare benign ocular tumour in children, composed of glial cells, vascular tissue, and sheets of pigmented epithelial cells. Although generally thought to be congenital, acquired cases are known to exist. It usually presents with reduced visual acuity and/or strabismus and it can be associated with several syndromes, including Neurofibromatosis Type 2. There is no consensus on the management of combined hamartoma of the retina and retinal pigment epithelium. We present a case, including MRI features, of a 4,5-years-old girl with a combined hamartoma of the retina and retinal pigment epithelium. 2 of 3 birpublications.org/bjrcr
Association of bilateral, multiple presumed retinal astrocytic proliferations with combined hamartoma of retina and retinal pigment epithelium in a 9-year-old male child with neurofibromatosis type 2
Indian Journal of Ophthalmology, 2016
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Optical Coherence Tomography and Infrared Images of Astrocytic Hamartomas Not Revealed by Funduscopy in Tuberous Sclerosis Complex
Retina, 2017
Purpose: To detect, describe, and classify the morphologic characteristics of astrocytic hamartomas in tuberous sclerosis complex, using both spectral-domain optical coherence tomography (OCT) and infrared images. Methods: Ten subjects (20 eyes) with tuberous sclerosis complex underwent a complete ophthalmologic examination and multimodality imaging with spectral-domain OCT and infrared images. The imaging protocol included a 30°scan angle of the posterior pole and of the four quadrants. Line scans, detail, raster, and posterior pole patterns were used. The identified astrocytic hamartomas were described and characterized qualitatively and quantitatively. Results: Forty-four hamartomas were detected in 8 patients. In five cases, lesions were bilateral. Thirty of these hamartomas had not been revealed by previous ophthalmoscopy. Through multimodality imaging, it was possible to define multiple lesions with characteristic optical reflective qualities. All the 44 hamartomas were measur...
Combined Hamartoma of the Optic Disc and Retinal Pigment Epithelium—3 Years of the Follow-Up with Semi-Automated Kinetic Perimetry
Open Journal of Ophthalmology, 2012
Aim: To present a case of hamartoma of the optic disc and Retinal Pigment Epithelium (RPE) and follow up of the visual function over three-years period. Methods: A seventeen-year-old boy has observed reduced visual acuity in his left eye. The visual acuity was 0.2 and there was RAPD in the left eye. Fundoscopy revealed an elevation of the optic disc obscuring disc vessels with epiretinal gliosis. Fluorescein angiography demonstrated hyperfluorescent saccular dilatations with leakage in the late phase. Ocular Coherence Tomography (OCT) showed hyperreflective elevation of the optic disc and epiretinal membrane. There was a juxtapapillary scotoma in Semi-automated Kinetic Perimetry (SKP). There was no systemic diseases. Results of blood tests, CT and MRI of CNV were normal. Results: After 3 years period of the follow-up the visual acuity was 0.1 and there was a progression of the visual field defect to the altitudinal scotoma in the upper hemisphere. Fluorescein anhiography and OCT revealed the same. Conclusion: Hamartoma of RPE and optic disc is a rare condition consisting of glial, vascular and RPE cells. It should be differentiated from optic disc oedema and vascular tumors of the retina. Assessment of the visual function is very important in the longitudinal follow-up.
Optic nerve giant cell astrocytoma in tuberous sclerosis complex
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2018
Tumour shown extending into optic nerve at level of lamina cribrosa (HPS). Middle: Von Kossa stain for calcium shows calcification of optic nerve distal to globe. Bottom: Neurofilament immunostain indicates axonal diminution in the optic nerve distal to globe. HPS = hematoxylin, phloxine and saffron.
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