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1996, Obstetrics & Gynecology
To describe trends in pregnancy-related mortality and risk factors for pregnancy-related deaths in the United States for the years 1991 through 1997. METHODS: In collaboration with the American College of Obstetricians and Gynecologists and state health departments, the Pregnancy Mortality Surveillance System, part of the Division of Reproductive Health at the Centers for Disease Control and Prevention, has collected information on all reported pregnancy-related deaths occurring since 1979. Data include those present on death certificates and, when available, matching birth or fetal death certificates. Data are reviewed and coded by clinically experienced epidemiologists. The pregnancy-related mortality ratio was defined as pregnancy-related deaths per 100,000 live births. RESULTS: The reported pregnancy-related mortality ratio increased from 10.3 in 1991 to 12.9 in 1997. An increased risk of pregnancy-related death was found for black women, older women, and women with no prenatal care. The leading causes of death were embolism, hemorrhage, and other medical conditions, although the percent of all pregnancy-related deaths caused by hemorrhage declined from 28% in the early 1980s to 18% in the current study period. CONCLUSION: The reported pregnancy-related mortality ratio has increased, probably because of improved identification of pregnancy-related deaths. Black women continue to have an almost four-fold increased risk of pregnancy-related death, the greatest disparity among the maternal and child health indicators. Although review of pregnancyrelated deaths by states remains an important public health function, such work must be expanded to identify factors that influence the survival of women with serious pregnancy complications.
2000
Problem/Condition: The risk of death from complications of pregnancy has decreased approximately 99% during the twentieth century, from approximately 850 maternal deaths per 100,000 live births in 1900 to 7.5 in 1982. However, since 1982, no further decrease has occurred in maternal mortality in the United States. In addition, racial disparity in pregnancy-related mortality ratios persists; since 1940, mortality ratios
MMWR. CDC surveillance summaries : Morbidity and mortality weekly report. CDC surveillance summaries / Centers for Disease Control, 1997
The Healthy People 2000: National Health Promotion and Disease Prevention Objectives specifies goals of no more than 3.3 maternal deaths per 100,000 live births overall and no more than 5.0 maternal deaths per 100,000 live births among black women; as of 1990, these goals had not been met. In addition, race-specific differences between black women and white women persist in the risk for pregnancy-related death. This report summarizes surveillance data for pregnancy-related deaths in the United States for 1987-1990. The National Pregnancy Mortality Surveillance System was initiated in 1988 by CDC in collaboration with the CDC/American College of Obstetricians and Gynecologists Maternal Mortality Study Group. Health departments in the 50 states, the District of Columbia, and New York City provided CDC with copies of death certificates and available linked outcome records (i.e., birth certificates or fetal death records) of all identified pregnancy-related deaths. During 1987-1990, 1,4...
Paediatric and Perinatal Epidemiology, 2005
Deaths from pregnancy complications remain an important public health concern. Nationally, two systems collect information on the number of deaths and characteristics of the women who died from complications of pregnancy. The Centers for Disease Control and Prevention's (CDC) National Center for Health Statistics (NCHS) reports maternal mortality through the National Vital Statistics System (NVSS); CDC National Center for Chronic Disease Prevention and Health Promotion's Pregnancy Mortality Surveillance System (PMSS) conducts epidemiological surveillance of pregnancyrelated deaths. The numbers of deaths reported by these two systems have differed over the past two decades; our objective was to determine the magnitude and nature of these differences. For 1995-97, we compared maternal deaths in the NVSS with pregnancy-related deaths in PMSS for the 50 States, Washington DC and New York City. Pregnancy-related deaths whose underlying cause was assigned to ICD-9 codes 630-676 by NVSS were classified as maternal deaths; those coded outside 630-676 were not. There were 1387 pregnancy-related deaths in PMSS and 898 maternal deaths in the NVSS; 54% of these deaths were reported in both systems, 40% in PMSS only, and 6% in NVSS only. Pregnancy-related deaths due to haemorrhage, embolism, and hypertensive complications of pregnancy were proportionately more often identified by NVSS as maternal deaths than those from cardiovascular complications, medical conditions or infection. From the 1471 unduplicated deaths classified as maternal or pregnancy-related from either reporting system, we estimated a combined pregnancyrelated mortality ratio of 12.6/100 000 live births for 1995-97, compared with 11.9 for PMSS only and 7.5 for NVSS only. The identification and classification of these events is dependent on the provision of complete and accurate cause-of-death information on death certificates. Changes in the guidelines for coding maternal deaths under ICD-10 may change the relationship in the number of deaths resulting from pregnancy reported by these two systems.
EXECUTIVE SUMMARY Maternal mortality, or deaths from pregnancy-related causes, is on the rise, both in California and the United States (U.S.). The rate of maternal deaths in California in 1999 was 8.0 deaths per 100,000 live births and by 2008 it was 14.0 deaths per 100,000 live births. African-American women are roughly four times more likely to die from pregnancy-related causes than women in all other racial/ethnic groups. Maternal deaths are rare; yet rising rates serve as a warning sign and merit further investigation. Improved vital statistics data reporting may account for about a third of the rise, leaving about two-thirds of maternal deaths that are likely due to other causes such as changes in the health status of women, changes in health care services, or the emergence of other social/environmental factors. Another reason to investigate the rise in maternal mortality is the accompanying rise in rates of pregnancy-related injury or illness, referred to as maternal morbidit...
2001
Prologue: Why Surveillance Still Matters-i 1. Structure of Pregnancy-Related Mortality Surveillance in the United States-1 2. Definition of Terms-5 3. Classifying a Woman's Death in Relation to Pregnancy-7 Cases where causal relationship may be unclear-10 4. Identifying Cases-13 Cause-of-death codes on death certificates-15 Manual review of death certificates-16 Check box indicating pregnancy on death certificates-17 Linking vital records-18 Searches of other computerized data sources-20 Other sources of information-21 Autopsy record review-21 Medical record review-21 5. Reviewing Pregnancy-Related Deaths-23 Maternal mortality review committees-25 Issues to review-29 Sources of information-30 Components of review-32 Correcting or improving cause-of-death information on a death certificate-36 Legal issues: liability and confidentiality-37 6. Analyzing and Interpreting the Findings-39 Quantitative analysis-39 Qualitative analysis-41 Using quantitative and qualitative data together-42 Issues related to small numbers-43 7. Taking Action-45 Making and implementing recommendations-46 Disseminating findings and recommendations-46 8. Evaluating the Surveillance System-49 Internal evaluation-49 External evaluation-50 9. Special Issues-51 Funding-51 Monitoring maternal health and morbidity/near misses-51 Epilogue-53 Appendices A. Instructions for completing the cause-of-death section of death certificates B. States with check boxes to indicate pregnancy on their death certificates C. The pregnancy-related portion of the proposed U.S. standard certificate of death D. State Review Provisions, ACOG 2000 E. Examples of data abstraction forms for medical records F. Example of questionnaire for interviews after pregnancyrelated deaths G. Extracts from "State Level Expert Review Committees-Are They Protected?" H. Measures of pregnancy-related mortality I. Example of a maternal mortality review committee's report-William Foege, M.D. i Strategies to Reduce Pregnancy-Related Deaths related to pregnancy-before, during, or after delivery. Each year six million women become pregnant, almost four million give birth, and over one million experience pregnancy-related complications. This means that pregnancy-related complications are a significant burden on women, their families, and society in economic, social, and personal terms (Unpublished article: Danel I, Berg CJ, Atrash HK, Johnson CH. The magnitude of maternal morbidity during labor and delivery, United States, 1993-1997.). Public health surveillance-identifying and reviewing pregnancy-related deaths, analyzing the findings, and taking action-should decrease a woman's risk of mortality due to pregnancy as well as help the many women who suffer pregnancy-related morbidity without dying. ii 1 Structure of Pregnancy-Related Mortality Surveillance in the United States This manual describes strategies for conducting pregnancy-related or maternal mortality surveillance in the United States. This surveillance is an ongoing process of identifying pregnancy-related deaths, reviewing the factors that led to those deaths, analyzing and interpreting the information gathered, and acting on the results so as to reduce such deaths in the future. The ultimate purpose of this surveillance process is to stimulate action rather than merely to count cases and calculate rates or ratios. All these steps-identification, data collection and analysis, and action-are needed on an ongoing basis in order to justify the effort and reduce pregnancy-related deaths. For pregnancy-related mortality surveillance to be successful, many people from many groups in many different roles must collaborate. In the United States, pregnancy-related mortality surveillance is a public health function, primarily coordinated by the states, although some large counties and cities also undertake this activity. Clinicians and health care professionals play vital roles in many parts of the surveillance process, as do social service and educational agencies, professional organizations, community groups, and the health care industry. Federal agencies assist in coordinating surveillance activities, providing technical assistance, and compiling national data. This manual addresses issues and tasks that are important for health departments, clinicians, vital statistics personnel, pregnancy-related mortality review committees, legislators, and community groups. Pregnancy-related mortality surveillance consists of several steps that occur in a more or less sequential fashion. Although each 1 Strategies to Reduce Pregnancy-Related Deaths state has its own unique structure, in every state, pregnancyrelated mortality surveillance requires similar steps: Identify pregnancy-related deaths. Review the medical and non-medical causes of death. Analyze and interpret the findings. Act on the findings. The concept of pregnancy mortality surveillance as an ongoing process with the ultimate purpose of action is an important one. Too often surveillance stops after identifying and counting deaths. However, pregnancy-related mortality surveillance requires all four steps-identification, investigation, analysis, and action-in a continuing fashion to make the effort worthwhile. * See Table 1 for definitions of ICD and ACOG/CDC terms. Box 1 5 Strategies to Reduce Pregnancy-Related Deaths ■ Not-pregnancy-related death. The death of a woman while pregnant or within 1 year of termination of pregnancy, due to a cause unrelated to pregnancy (Figure 1). These terms improve surveillance in several ways: ■ They help identify deaths caused by pregnancy by promoting the idea of first identifying deaths with a temporal relationship to pregnancy (pregnancy-associated deaths) as a group from which to find those deaths caused by pregnancy (pregnancy-related deaths).
Obstetrics & Gynecology, 2003
To examine the association between health care services variables and pregnancy-related death using a contemporary geographically defined population and enhanced methods for case identification.
Abstract OBJECTIVE: To compare specific maternal and clinical characteristics and contributing factors among the five leading causes of pregnancy-related mortality to develop focused clinical and public health prevention programs. METHODS: California pregnancy-related deaths from 2002-2005 were identified with enhanced surveillance using linked birth and death certificates. A multidisciplinary committee reviewed medical records, autopsy reports, and coroner reports to determine cause of death, clinical and demographic characteristics, chance to alter outcome, contributing factors (at health care provider, facility, and patient levels), and quality improvement opportunities. The five leading causes of death were compared with each other and with the overall California birth population. RESULTS: Among the 207 pregnancy-related deaths, the five leading causes were cardiovascular disease, preeclampsia or eclampsia, hemorrhage, venous thromboembolism, and amniotic fluid embolism. Among the leading causes of death, we identified differing patterns for race, maternal age, body mass index, timing of death, and method of delivery. Overall, there was a good-to-strong chance to alter the outcome in 41% of deaths, with the highest rates of preventability among hemorrhage (70%) and preeclampsia (60%) deaths. Health care provider, facility, and patient contributing factors also varied by cause of death. CONCLUSION: Pregnancy-related mortality should not be considered a single clinical entity. Reducing mortality requires in-depth examination of individual causes of death. The five leading causes exhibit different characteristics, degrees of preventability, and contributing factors, with the greatest improvement opportunities identified for hemorrhage and preeclampsia. These findings provide additional support for hospital, state, and national maternal safety programs.
Obstetrics & Gynecology, 2015
OBJECTIVE: To compare specific maternal and clinical characteristics and contributing factors among the five leading causes of pregnancy-related mortality to develop focused clinical and public health prevention programs.
Annals of Epidemiology, 2007
PURPOSE: Our study aim was to identify factors that may contribute to the racial disparity in pregnancyrelated mortality. METHODS: We examined differences in severity of disease, comorbidities, and receipt of care among 608 (304 African-American and 304 white) consecutive patients of non-Hispanic ethnicity with one of three pregnancy-related morbidities (pregnancy-related hypertension, puerperal infection, and hemorrhage) from hospitals selected at random from a statewide region. RESULTS: African-American women had more severe hypertension, lower hemoglobin concentrations preceding hemorrhage, more antepartum hospital admissions, and a higher rate of obesity. The rate of surgical intervention for hemorrhage was lower among African-Americans, although the severity of hemorrhage did not differ between the two racial groups. More African-American women received eclampsia prophylaxis. After stratifying by severity of hypertension, we found that more African-Americans received antihypertensive therapy. The rate of enrollment for prenatal care was lower in the African-American group. Among women receiving prenatal care, African-American women enrolled significantly later in their pregnancies. CONCLUSIONS: We have identified racial differences in severity of disease, comorbidities, and care status among women with pregnancy-related complications that would place African-Americans at disadvantage to survive pregnancy. These differences are potentially modifiable.
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2007
Objective: We compared official maternal mortality statistics with those from a special study covering all pregnancy-associated deaths in two European countries (Finland and France) and in two US states (Massachusetts and North Carolina) in 1999-2000 to characterize pregnancyrelated deaths that are not included in official statistics. Study design: We linked the official ICD-10-based maternal mortality data for 84 deaths with study data on 404 pregnancy-associated deaths. Results: Of the pregnancy-associated deaths, 151 were pregnancy-related. We found 69 pregnancy-related deaths that had not been included as maternal deaths, and two deaths coded as maternal deaths that did not meet our definition for a pregnancy-related death. In total, 58 of these 69 deaths were from medical causes and 11 were from external causes or injuries (10 postpartum depression-related suicides and one accidental drug poisoning). The unreported deaths due to medical causes included 27 direct, 15 indirect, and two direct/indirect pregnancyrelated deaths and 14 possibly pregnancy-related deaths. The most common causes of the unreported deaths due to medical causes were intracerebral hemorrhage (7 deaths), peripartum cardiomyopathy (4), pulmonary embolism (4) and pregnancy-induced hypertension (4). Conclusions: The collection of data on pregnancy-related and pregnancy-associated deaths is useful for countries with low maternal mortality figures. The use of various data-collection methods may substantially increase the quality of maternal mortality statistics. #
OBJECTIVE: To compare specific maternal and clinical characteristics and contributing factors among the five leading causes of pregnancy-related mortality to develop focused clinical and public health prevention programs.
Journal of Women's Health, 2014
This article provides a brief overview of the work conducted by the Division of Reproductive Health at the Centers for Disease Control and Prevention on severe maternal morbidity and mortality in the United States. The article presents the latest data and trends in maternal mortality and severe maternal morbidity, as well as on maternal substance abuse and mental health disorders during pregnancy, two relatively recent topics of interest in the Division, and includes future directions of work in all these areas.
Annals of Epidemiology, 2006
PURPOSE: Researchers are increasingly studying maternal mortality in the context of maternal morbidity in order to identify risk and protective factors operating at each point along the morbidity-mortality continuum. This study examined factors associated with mortality in pregnant women with severe morbidity. In particular, the Black-White disparity was examined. METHODS: Illinois vital records data were linked to identify maternal deaths and other pregnant women with severe morbidity. Pregnancy-related deaths and high risk survivors were compared and case fatality rates were computed. Condition-specific and multivariable analyses were conducted, and time of death was examined. RESULTS: The overall risk of maternal death was 37.1 per 10,000 high risk pregnant women in Illinois from 1994 to 1998. Women who were older, African American, unmarried, or living in Chicago were at elevated risk of death. The adjusted relative risk for the Black-White disparity was 3.7 among all high risk pregnant women and 8.5 among women with hypertensive disorders. A greater proportion of African American and Hispanic women died within 7 days of delivery compared to White women. CONCLUSIONS: Medical risk status alone cannot explain disparities in maternal mortality. The Black-White disparity for risk of death persisted in both overall and condition-specific analyses.
Obstetrics and gynecology, 2015
Annals of Epidemiology, 2004
PURPOSE: African-American women have a 2-to 4-fold increased risk of pregnancy-related death compared with Caucasian women. We conducted this study to determine if differences in a combination of socioeconomic and medical risk factors may explain this racial disparity in pregnancy-related death. METHODS: Pregnancy-related deaths of African-American (N ϭ 60) and Caucasian (N ϭ 47) women were identified from review of pregnancy-associated deaths (N ϭ 400) ascertained through cause of death on death certificates, electronic linkage of birth and death files, and review of the hospital discharge database for the State of North Carolina, during the period between 1992 and 1998. Controls (N ϭ 3404) were randomly selected from all live births for the same 7-year period. Logistic regression was used to model the association between race and pregnancy-related death. RESULTS: The unadjusted odds ratio (OR) for pregnancy-related death for African-Americans compared with Caucasians was 3.07 (95% confidence interval [CI], 2.08, 4.54). After controlling for gestational age at delivery, maternal age, income, hypertension, and receipt of prenatal care, African-American race remained a significant predictor variable (OR 2.65 [95% CI 1.73, 4.07]). CONCLUSIONS: Our analysis confirms that there is a strong association between race and pregnancyrelated death, even after adjusting for potential predictors and confounders.
Anesthesiology Clinics, 2020
Black women have experienced injustice and abuse in the United States since the 1600s. Institutionalized racism has led to black women's deep distrust of health care providers and medical research processes, leading to disparities in accessing care and dramatic underrepresentation in research. Black women die at a rate of 3 to 4 times greater compared with their white counterparts, regardless of socioeconomic factors. Hospital factors play a prominent role in black women experiencing greater morbidity and mortality, and anesthesiologists are uniquely positioned to help erase some of these disparities by focusing on these vulnerabilities.
Obstetrics & Gynecology, 2016
To develop methods for trend analysis of vital statistics maternal mortality data, taking into account changes in pregnancy question formats over time and between states, and to provide an overview of U.S. maternal mortality trends from 2000 to 2014. METHODS: This observational study analyzed vital statistics maternal mortality data from all U.S. states in relation to the format and year of adoption of the pregnancy question. Correction factors were developed to adjust data from before the standard pregnancy question was adopted to promote accurate trend analysis. Joinpoint regression was used to analyze trends for groups of states with similar pregnancy questions. RESULTS: The estimated maternal mortality rate (per 100,000 live births) for 48 states and Washington, DC (excluding California and Texas, analyzed separately) increased by 26.6%, from 18.8 in 2000 to 23.8 in 2014. California showed a declining trend, whereas Texas had a sudden increase in 2011-2012. Analysis of the measurement change suggests that U.S. rates in the early 2000s were higher than previously reported.
American Journal of Obstetrics and Gynecology, 2005
Objective: The purpose of this study was to examine the temporal change in fetal death risk in the US from 1991 to 1997, and to assess the extent to which changes in registration practices and labor induction have contributed to that change. Study design: This was a cohort study of all singleton pregnancies 20 to 43 weeks of gestation in 1991 and 1997 in the US. Results: From 1991 to 1997, the overall fetal death rate fell from 77.6 to 67.8 per 10,000 total births. However, fetal deaths at 20 to 22 weeks as a proportion of total births increased from 14.5 to 16.9 per 10,000. In a Cox regression analysis, the crude period effect (1997 vs 1991) at 40 to 43 weeks was 0.87 (95% CI 0.80-0.94), and remained virtually unchanged (HR 0.88, 95% CI 0.81-0.96) after adjustment for maternal sociodemographic, medical, and lifestyle risk factors. In ecologic (Poisson regression) analysis based on states as the unit of analysis, the crude period effect in non-Hispanic whites (RR 0.79, 95% CI 0.74-0.84) disappeared (RR 0.98, 95% CI 0.82-1.16) after adjusting for induction of labor. The effect of induction in blacks was limited to 42 to 43 weeks in those at high risk. Conclusion: Increased registration is probably responsible for an increase in fetal death risk at 20 to 22 weeks of gestation, whereas the increasing trend toward routine labor induction at and after term appears to have reduced the risk of fetal death, especially among whites.
North Carolina medical journal
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