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1 Advances in cardiac surgery toward the mid-20th century created a need for an artificial means of stimulating the heart muscle. Initially developed as large external devices, technological advances resulted in miniaturization of electronic circuitry and eventually the development of totally implantable devices. These advances continue to date, with the recent introduction of leadless pacemakers. A microcontroller pacemaker, along with a PC-based programmer is proposed for bradycardia pacing. The algorithm is implemented in Arduino microcontrollers, which is programmed using PC and MATLAB. A ventricular signal with random or frequent lost beats is studied, and a pacing system is proposed for regulation of the simulated heart signal as in VVI mode. The experimental results show the ability of the system in detecting absence of the heartbeat in the expected times, and composing the required pacing pulses.
In this project work A state machine approach has been followed to design and implement a single and dual chamber pacemaker in response to different heart beats from 35bpm-125bpm. The heart of the pacemaker system rests in the pulse generator which forms the major portion of the project. It has been developed using Verilog and implemented in hardware using FPGA. In the FSM, first an input event is detected. Once this input is detected a timer is set which will be the time between heartbeats, thus giving 35-125 heartbeats per minute. This pacemaker responses only when the QRS wave is low or high in compared to normal ECG wave. The designing and verification is done through verilog on Xilinx 14.1. Also, ECG signal is generated in modelsim 10.1b. The pacemaker response is verified with various heart beats from 35-125bpm.
The International Arab Journal of Information Technology, 2008
This paper describes the development of a heart rate monitor system based on a microcontroller. It offers the advantage of portability over tape-based recording systems. The paper explains how a single-chip microcontroller can be used to analyse heart beat rate signals in real-time. In addition, it allows doctors to get the heart beat rate file of the patient by email every twenty four hours. It can also be used to control patients or athletic person over a long period. The system reads, stores and analyses the heart beat rate signals repetitively in real-time. The hardware and software design are oriented towards a single-chip microcontroller-based system, hence minimizing the size. The important feature of this paper is the use of zero crossing algorithm to compute heart rate. It then processes on real-time the information to determine some heart diseases.
2000
Because the voltage amplitude of a heart beat is small compared to the amplitude of exponential noise, pacemakers have difficulty registering the responding heart beat immediately after a pacing pulse. This thesis investigates use of digital filters, an inverse filter and a lowpass filter, to eliminate the effects of exponential noise following a pace pulse. The goal was to create a filter which makes recognition of a haversine wave less dependent on natural subsidence of exponential noise. Research included the design of heart system, pacemaker, pulse generation, and D sensor system simulations. The simulatf model includes the following components: \ • Signal source, A MA TLAB generated combination of a haversine signal, exponential noise, and myopotential noise. The haversine signal is a test signal used to simulate the QRS complex which is normally recorded on an ECG trace as a representa-
Health monitoring systems becomes a hot topic and important research field. Electrocardiogram (ECG) signal is a diagnoses tool that measures and records the electrical activity of the heart, taking care of patient's health. Therefore, monitoring this signal becomes a necessary need to take care of human health. In this paper, two procedures are proposed; first, monitoring the ECG signal, second for sending the signal of monitoring patients and ECG data through Serial communication port to the other pc or nurse. AT89C51 microcontroller uses to perform these procedures including all the necessary connections of the microcontroller with other components and programming the microcontroller using assembly language to send the signal serially. At both transmitting and receiving sides, the signal was gives the same setting of baud rate, stop bits, number of data bits, parity to ensure secure arrival of data without any lossless. The Electrocardiogram (ECG) has an essential diagnostic tool that measures and records the electrical activity of the heart. A wide range of heart conditions has detected when interpreting the recorded ECG Signals. These qualities have make the ECG a perfect instrument for patient monitoring and supervision. The commonly for using ECG-machine has used for diagnosis and supervision at the present to consider expensive and stationary (1). The normal heart beat has begun as an electrical impulse generated in the sinoatrial node of the right atrium. From there, the electrical activity has spread as a wave over the atria and arrives at the atrioventricular node about 200ms later. The atrioventricular node has the electrical only connection between the atria and ventricles. In approximately 100ms, the wave front has emerge on the other side and rapidly spreads to all parts of the inner ventricular surface via the His-Purkinje system (2). A typical ECG tracing of a normal heartbeat (or cardiac cycle) has consisted of a P wave, a QRS complex and a T wave as show in Figure (1) An interesting line of research has focused on how to use the microcontroller to monitor the ECG signal as well as all the aspects have related to the microcontroller such as the connections, programming and also how to send this signal.
This research paper aims at a dual-chamber pacemaker design which is being simulated using VLSI architecture in Xilinx and is being modified by changing clock cycle to provide better results as compared to other pacemaker. It follows a state machine approach to achieve the desired purpose. The heart of the system is the pacing pulse generator, which forms the major part of the project. It is being designed using VHDL and implemented in hardware using FPGA. The code has been modified and optimized for different modes of stimulation. Reasonable components in the construction of the detection circuit and other peripherals had been used for simulation. It had been assured that memory and data compression techniques monitoring devices remotely had been used for improvements in the overall performance.
Jurnal Teknokes
Electrocardiograph (ECG) is one of the diagnostic sciences that is often studied in modern medicine, used to detect damage to the components of the heart or disorders of the heart rhythm called arrhythmias. The purpose of this research is to develop an Electrocardiograph simulator that is equipped with arrhythmia. The main design consists of an Arduino Mega 2560 microcontroller, MCP4921 DAC (Digital to Analog Converter) circuit, a network resistor, and a sensitivity selection circuit. The MCP4921 type DAC converts the digital signal data into analog data which will then be forwarded to the resistor network circuit as a signal formation for each lead. The basic signal image data used for the formation of normal Electrocardiograph and arrhythmias were taken from the Electrocardiograph recorder using Phantom Electrocardiograph. Based on the readings on the Beat Per Minute setting of the module to the Beat Per Minute printout on the Electrocardiograph recorder, the error rate value for ...
Biomedizinische Technik/Biomedical Engineering, 2004
Chronotropic incompetent patients are unable to adapt their heart rate adequately to the actual level of strain (mental stress, exercise). This disease which can be interpreted as an interruption of the information flow between the autonomic nervous system (ANS) and the intrinsic rhythm generator inside the heart (sinus node) is most often treated with implantable rate-responsive pacemakers. These are equipped with at least one sensor in order to provide a rate-responsive algorithm with information concerning the body's current strain, thereby allowing an adjustment of the stimulation rate. From the physiological point of view an optimal system can be defined as one which is capable of bridging the pathological gap between the ANS and the sinus node [9, 11]. Based on this definition, any such pacemaker should be able to restore both sympathetic and parasympathetic stimuli to the pacing frequency. As direct sensing of the activity of afferent heart nerves is impossible, reasonable substitutes have to be used to generate some ANS related information. The system described here is based on the dromotropic effect. The sensitive signal is the conduction time between the right atrium and the ventricles (atrio-ventricular conduction time, AVCT). AVCT can be simply measured by means of the intra-cardiac electrogram where it is defined as the time interval starting with the right-atrial stimulus and ending with the following right-ventricular depolarization. AVCT is influenced by the ANS, both by the sympathetic and the parasympathetic system. Provided that the conduction is regular and that there is no atrial fibrillation, AVCT can be used for heart rate control in a pacemaker. In view of this potential we developed a concept for a rate-responsive algorithm, which has been realized under laboratory conditions [4]. This concept was based on a thorough experimental analysis of the individ
Annals of Surgery, 1952
2010
The present work describes the design and analysis of a control system for regulating the heart rate using pacemaker in an efficient way. The total control system in this work is considered to be composed of cardio vascular system duly energized by one pacemaker system as operated in a closed loop manner with unity negative gain in the closed loop feedback path. The design emphasizes on the optimality in operation of the control process as determined by the performance index (PI) of the total process. For attaining the optimality in performance (as realized in terms of PI), one compensator is, however, used along with the cascade arrangement of the cardio vascular system driven by the concerned pacemaker. Hence, the overall open loop transfer function in the forward path is simply the product of the transfer functions of the pacemaker, the cardio vascular system and the compensator system. The controllability and the observability of the system are tested, and the system is found to...
2007 Computers in Cardiology, 2007
Implanted cardiac pacemakers are becoming more sophisticated. However, accurate detection of pacemaker stimuli is a problem for most ECG machines because of the very short duration of the stimuli, sometimes only 0.3ms. In addition, the relatively new technique of biventricular pacing involves two closely timed stimuli to activate the ventricles separately. Detection of all stimuli in a paced patient is therefore becoming increasingly difficult for conventional ECG machines. In order to address this problem, a more recently developed electrocardiograph, namely the Burdick Atria 6100, introduced enhanced front end electronics. This study assessed its accuracy in detecting pacemaker stimuli and assessed the choice of lead for their detection. 51 patients were initially recruited. Five were excluded for various reasons. Pacemaker activity was detected in 45/46 patients and in 16/16 patients with biventricular pacemakers, two closely paced stimuli were detected.
Journal of Electrocardiology, 1979
A microcomputer controlled device for delivering precisely timed stimuli to cardiac chambers is described. Stimulation patterns are determined by software, rather than hardware design, resulting in enhanced flexibility. Additionally, by providing timing inputs to conventional laboratory stimulators, this instrument can convert these limited use devices into ones capable of generating complex cardiac stimulation patterns at moderate cost.
Pacing and Clinical Electrophysiology, 1985
Computer simulation of dual chamber pacemaker algorithms using a realistic heart model. Single and dual chamber pacing algorithms have been incorporated into a realisd'c compuler model of cardiac electrical activation. The model enables dijjerenl pacemaker aJgorifhms to be tested, it allows prediction of iheir behavior, and if produces a simulated ECG record for each case. The computer model has been used to test eight different modifications of a simple DDD mode to prevenl or (erminale pocemaker-mediafed "endless loop" tachycardia: (1} constant prolongation of the atrial channel refractory period; [2} prolongation of the atrial refractory period after a ventricular premature heal fVPB); (3) atria/ pacing synchronously witb a VPB: [4} simple ra(e conlrol; f5) rate control in which (he VA counter is not reset: {6} no ventricular pacing after an atrial premature bea(; (7) rate limitation of atriai sensing; and (8) a comhinalion of DDD and high frequency atrial stimulafion modes. These modijications were lested wi(h VPBs, atrial premature bents, afrial sfimu/ation without capfure. and accelerafing sinus tachycardia. Only the pacemaker designed not to pace ihe ventricles following an Qtrial premalure beaf behaves satisfactorily in all four circumstances. Furlher possibilities for the developmenl and use of a pacemaker-orienfed computer heart model are discussed.
The paper describes implementation of a new technology of digital systems design in case of medical measurement interface of IMPULS system used for acquisition of ECG signal from pacemaker patients. Similarly as in other today applications, the processor circuit is a base of digital system, however – regarding large number of performed tasks – it is assisted by additional peripheral logic circuits. At the beginning, there were used standard elements (logic gates, counters, registers, etc.), however, a growing complexity of beyond processor operations encouraged designers to apply the programmable circuits. The paper presents the stages of digital system development that has been implemented in medical measurement interface. It is the excellent example of possibility to integrate several standard elements in one integrated circuit.
2011
This paper presents a method for designing and producing a temporary cardiac pacemaker device to cure cardiac arrhythmia. To produce this device Schmitt Trigger Circuit was used to control rate, Op-Amp comparator circuit to regulate pulse width, monostable to regulate pace refractory period and sense refractory period, and it is worthy to mention hat pacemaker works in VOO and AOO. Parameters of this device were measured by employing Sigmapace 1000.
Measurement, 1989
The object of the so-called Electrocardiographic Inverse Problem is the algorithmic analysis and diagnosis of the electrocardiogram (ECG). A part of this general problem is the Pacemaker Inverse Problem, which means the analysis of the ECG in order to establish details of heart-pacemaker interaction (HPI) with special reference to the diagnosis of pacemaker failure. The solution to this problem is of practical importance, because it is often impossible to evaluate such records clinically. The ECG patterns of natural cardiac activity and of the events stimulated by the pacemaker may not be distinguishable and many combinations of potential response of the implanted device have to be taken into account. A computer system providing automatic analysis of the HPI, based on ECG data, has been developed and implemented on an IBM PC AT computer. The system uses a complex algorithm which enables the evaluation of all possible combinations of HPI events, and establishes for each of these combinations its correspondence to the specified pacemaker algorithm. The system is written in Turbo Pascal and its source text has more than 11000 lines.
IEEE Transactions on Biomedical Engineering, 1997
Abstruct-An automatic physiological control system for the actively filled, alternately pumped ventricles of the volumetrically coupled, electrohydraulic total artificial heart (EHTAH) was developed for long-term use. The automatic control system must ensure that the device: 1) maintains a physiological response of cardiac output, 2) compensates for any nonphysiological condition, and 3) is stable, reliable, and operates at a high power efficiency. The developed automatic control system met these requirements both in vitro, in week-long continuous mock circulation tests, and in vivo, in acute open-chested animals (calves). Satisfactory results were also obtained in a series of chronic animal experiments, including 21 days of continuous operation of the fully automatic control mode, and 138 days of operation in a manual mode, in a 159-day calf implant. Zndex Terms-Artificial biological organs, biological control systems, blood pumps, implantable biomedical devices, microprocessor applications. H. C. Kim is with the Artificial
International Journal of Medical Science, 2014
This paper the design and development of Micro-controller based ECG simulator intended to use in testing, calibration and maintenance of ECG machines and to support biomedical engineering student's education. It generates all 12lead ECG signals of varying heart rate, amplitude and different noise contamination in a manner which reflects true noninvasive conditions. Since standard commercially available electronic components were used to construct the prototype simulator, the proposed design was also relatively inexpensive to produce. It is portable battery operated instrument with alphanumeric LCD display and keyboard for waveform selection. The operator can control the amplitudes of various signals and the name of selected signal will appear on 16X2 LCD display. The aim of the ECG tester is to produce the typical ECG waveforms of different leads combinations and as many arrhythmias as possible. The ECG simulator enables us to analyze and study normal and abnormal ECG waveforms without actually connecting it patients. During testing of ECG machines it is not possible to connect it to patient hence this instrument facilitates to the task. This can also used as teaching aid for Engineering and medical college laboratories for cardiac signal study and testing [3].
The American Journal of Cardiology, 2001
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