APPLICATIONS OF DENDRIMERS TO DRUG DELIVERY

International Journal of Applied Pharmaceutics, 2018

With the recent advances of nanotechnology, dendrimers are emerging as a highly attractive class of drug delivery vectors for cancer therapy. Dendrimers are multifunctional smart Nanocarriers to deliver one or more therapeutic agent safely and selectively to cancer cells. The high level of control over the synthesis of dendritic architecture makes dendrimers a nearly perfect (spherical) nanocarrier for site-specific drug delivery. The presence of functional groups in the dendrimers exterior also permits the addition of other moieties that can actively target certain diseases which are now widely used as tumor targeting strategies. Drug encapsulation, solubilization and passive targeting also equally contribute to the therapeutic use of dendrimers. Dendrimers are ideal carrier vehicles on cytotoxicity, blood plasma retention time, biodistribution and tumor uptake. In this review we highlight the advantages of dendrimers over conventional chemotherapy, toxicity and its management, following anticancer drugs delivered by using dendrimers and recent advances in drug delivery by various types of dendrimers as well as its diagnostic applications.

Journal of Drug Delivery and Therapeutics, 2016

This review gives concise information about the dendrimers, properties, synthesis and application in drug delivery, diagnosis and therapy. Due to their unique architecture these have improved physical and chemical properties. They show high solubility, miscibility and reactivity due to their terminal groups. Dendrimers have well defined size, shape, molecular weight and monodispersity. These properties make the dendrimers a suitable carrier in drug delivery application. Dendrimers are unimolecular miceller in nature and due to this enhances the solubility of poorly soluble drugs. Their compatibility with DNA, heparin and polyanions make them more versatile. Dendrimers, also referred as modern day polymers, they offer much more good properties than the conventional polymers. Due to their multivalent and mono disperse character dendrimers have stimulated wide interest in the field of chemistry biology, especially in applications like drug delivery, gene therapy and chemotherapy. Self assembly produces a faster means of generating nanoscopic functional and structural systems. But their actual utility in drug delivery can be assessed only after deep understanding of factors affecting their properties and their behavior in vivo.

Chem. Rev, 2009

European Journal of Pharmaceutics and Biopharmaceutics, 2009

About forty percent of newly developed drugs are rejected by the pharmaceutical industry and will never benefit a patient because of poor bioavailability due to low water solubility and/or cell membrane permeability. New delivery technologies could help to overcome this challenge. Nanostructures with uniform and well-defined particle size and shape are of eminent interest in biomedical applications because of their ability to cross cell membranes and to reduce the risk of premature clearance from the body. The high level of control over the dendritic architecture (size, branching density, surface functionality) makes dendrimers ideal carriers in these applications. Many commercial small molecule drugs with anticancer, anti-inflammatory, and antimicrobial activity have been successfully associated with dendrimers such as poly(amidoamine) (PAMAM), poly(propylene imine) (PPI or DAB) and poly(etherhydroxylamine) (PEHAM) dendrimers, either via physical interactions or through chemical bonding ('prodrug approach'). Targeted delivery is possible via targeting ligands conjugated to the dendrimer surface or via the enhanced permeability and retention (EPR) effect. The biocompatibility of dendrimers follows patterns known from other small particles. Cationic surfaces show cytotoxicity; however, derivatization with fatty acid or PEG chains, reducing the overall charge density and minimizing contact between cell surfaces and dendrimers, can reduce toxic effects.

Experimental Oncology, 2018

Aim: Dendrimers dendritic structural design holds vast promises, predominantly for drug delivery, owing to their unique properties. Dendritic architecture is widespread topology found in nature and offers development of specific properties of chemical substances. Dendrimers are an ideal delivery vehicle candidate for open study of the effects of polymer size, charge, and composition on biologically relevant properties such as lipid bilayer interactions, cytotoxicity, bio-distribution, internalization, blood plasma retention time, and filtration. This article reviews role of dendrimers in advanced drug delivery and biomedical applications.

Drug Delivery Systems, 2020

Dendrimer-based products 382 8.5 Conclusion 383 Disclosures 384 Abbreviations 384 Acknowledgments 385 References 385 Further reading 392 334 8. Dendrimers as novel drug-delivery system and its applications Drug Delivery Systems representation of dendrimers with different generations and its approximate diameter. 337 8.1 Introduction Drug Delivery Systems FIGURE 8.3 Ideal properties of dendrimers. 338 8. Dendrimers as novel drug-delivery system and its applications Drug Delivery Systems 1. divergent growth method; 2. convergent growth method;

Journal of Pharmaceutical & Scientific Innovation, 2016

Dendrimers are unique class of polymers which play an important role in emerging nanotechnology. Novel drug delivery is one of the most attractive potential applications of dendrimers. Dendrimers are macromolecules having highly branched, 3D structure, nanoscale architecture with monodispersity and high functionality. Dendrimers are dominated by the functional groups on the molecular surface for example; a dendrimer can be water soluble when its end groups like a carboxylic group. These features make it attractive candidates as drug carrier for controlled release or targeted delivery. Dendrimer is a smart polymer having various applicability in pharmaceutics, industry and diagnosis.

Aristotle University Medical Journal, 2009

Dendrimers, like all nanosystems, appear to be very interesting in modern therapeutics. Their multi-branched polymer structure as well as their physicochemical properties attribute a promising role in drug administration. Dendrimers can be used for chemotherapy, antibiotics administration etc. Their main advance is the target release of the drug in particular cell types and even in intracellular compartments. Moreover they may cross anatomical barriers while protecting the attached agent from early procession. Although the application of dendrimers in theurapeutics is significant, further evaluation of their safety as drug carriers is required.

Journal of Drug Delivery and Therapeutics, 2011

Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and target the active entity to the site of action. A number of novel drug delivery systems have emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery, dendrimer carriers being one of them. Dendrimers are highly branched, star-shaped macromolecules with nanometer-scale dimensions. It is a novel three dimensional structure and these three components are: a central core, an interior dendritic structure (the branches), and an exterior surface with functional surface groups. It is also improve the physical, chemical properties due to their structure. Its other properties like very small size, polyvalenc, monodispersit, stability make it an appropriate carrier for delivering drugs with precision and selectivity. The terminal groups are modified to attach biologically active substances for targeting purpose. Dendrimers are suitable for a wide range of targeted drug delivery, controlled drug delivery, gene delivery and industrial applications. Cationic surfaces of dendrimers show cytotoxicity, derivatization with fatty acid or PEG chains, reducing the overall charge density and minimizing contact between cell surfaces and dendrimers can reduce toxic effects. Different types of products are formulated by using dendrimers for treatment of many diseases. The present review has focused on the different strategies of their synthesis, different methods of drug entraptment, drug delivery and targeting, its applications, interactions involved in formation of drug-dendrimer complex along with characterization techniques employed for their evaluation, toxicity problems.