277 PLATELET-RICH FIBRIN_ A NEW.pdf

2020

The development of bioactive surgical additives, which are being used to regulate the inflammation and increase the speed of healing process, is one of the great challenges in oral surgery. Platelet-rich fibrin (PRF) is a second-generation platelet concentrate who was defined as an autologous leukocyte and PRF biomaterial, in which, platelets and leukocytes are collected with high efficiency such that the growth factors will able to release gradually during at least 1 week. The biologic effect of this fibrin matrix is: angiogenesis, immune control, harnessing the circulating stem cells, and wound protection by epithelial cover. The following article attempts to summarize our clinical cases regarding the technique of using PRF, focusing on its preparation, advantages of using it in oral surgery. Three cases with different clinical diagnoses were taken for this study in order to show the possible ways of application of PRF in the surgical field. In the first case, it is a 53 year-old ...

Platelet rich fibrin (PRF) and its application in oral surgery: A literature review, 2023

Platelet rich fibrin (PRF) is a autogenous platelet concentrate containing growth factors and cytokines, trapped in fibrin matrix. Growth factors which are present provides ideal environment for wound healing and regeneration of the tissues. Platelet Concentrate have evolved a long way since 1954. In recent time it has been used in the field of medical science including dentistry, oral surgery, plastic surgery, orthopaedic surgery etc. This review discuss the evolution of platelet concentrate, its preparation technique and its application in the field of dentistry and oral surgery. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

International journal of dental and clinical study , 2021

In 2000, Choukroun pioneered the use of platelet-rich fibrin (PRF). PRF is considered a second generation platelet concentrate. It is a fibrin mesh structure that stores a variety of growth factors and cytokines and gradually releases them during remodeling. PRF has a wide variety of applications in the field of oral surgery due to its biological potential to accelerate the woundhealing process and tissue regeneration. This review mentioned a number of possible PRF implementations in different oral surgical procedures. This review is based on the literature analysis of current oral surgical procedures including mandibular third molar surgery, preservation of extraction sockets, maxillary sinus augmentation, dressing, dental implant installation, osteonecrosis of jaw, oroantral communication closure, and periodontal surgery. These findings demonstrate that RPF can be employed widely in different types of oral surgical procedures.

2017

Platelet-rich fibrin (PRF) was first described by Choukroun et al. in France. It has been referred to as a second-generation platelet concentrate, which has been shown to have several advantages over traditionally prepared PRP. It’s a new generation of platelet concentrates geared to simplified preparation without biochemical blood handling. This article describes the evolution of this novel platelet concentrate and its applications in the field of Oral and Maxillofacial Surgery.

Gulhane Medical Journal, 2022

Medical research archives, 2023

The development of novel regenerative material to reduce inflammation and enhance healing process is one of the greatest task in clinical research. PRF (platelet rich fibrin) is an second generation platelet concentrate which has gained popularity in recent years due to its unique regenerative process. Platelet Rich Fibrin is completely autologous material with extended growth factor release compared to other growth concentrates. The standard quality and quantity of the fibrin matrix , leukocytes, platelets, and growth factors of PRF demands a standard protocol for preparation. The use of Platelet Rich Fibrin treatment has shown increased cellular proliferation, osteogenesis and mineralisation thereby enhancing wound healing capacity. Due to its versatility Platelet Rich Fibrin serves as workhorse in wound healing. This Review article attempts to encapsulate the technique, it's preparation and use of Platelet Rich Fibrin in the field of oral and maxillofacial surgery.

Int journal of drug research and dental science, 2020

The healing of hard and soft tissue is mediated by a wide range of intracellular and extracellular events that are regulated by signaling proteins. Platelets can play a crucial role in periodontal regeneration as they are the reservoirs of growth factors and cytokines which are the key factors for regeneration of bone and maturation of soft tissue. PRF is a natural fibrin-based biomaterial prepared from an anticoagulant-free blood harvest without any artificial biochemical modification that allows obtaining fibrin membranes enriched with platelets and growth factors. The main aim of this review article is to briefly describe the novel platelet concentrate PRF and its potential role in advanced surgical dentistry.

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Delta University Scientific Journal

Platelet-rich fibrin (PRF) is a second-generation platelet concentrate that is superior to PRP due to its mechanical and non-biochemical preparation and ability to slow down proteolysis and the rapid degradation of growth factors. The original preparation was used to produce various PRF variants; including sticky bone, advanced PRF (A-PRF), and injectable PRF (I-PRF). PRF is formed by fractioning autologous blood into elements that enhance wound healing and elements that do not, which are suspended in a fibrin matrix for preservation and slow release during healing. PRF is a flexible fibrin clot that can be tailored to a variety of tissue defect forms and can be prepared without anticoagulation. It can be molded into pellets, divided into smaller pieces, mixed with bone grafts, or flattened and utilized as a membrane. PRF is an osteoconductive scaffold that can be used to reconstruct cystic lesions and promote bone reformation. In addition, PRF can enhance wound healing and improve ridge preservation by introducing growth factors, angiogenic cytokines, and positive inflammatory cytokines. PRF in secondary alveolar cleft bone grafting (SABG) was found to improve gingival zenith when combined with iliac crest bone grafts. Studies have shown that I-PRF and A-PRF with iliac bone grafts in SABG reduce postoperative bone resorption, provide higher bone density, and provide functional and aesthetic support.

International Journal of Medicine, 2015

The aim of any invasive procedure is the complete eradication and elimination of the infection and associated necrotic tissue followed by repair and regeneration of the affected tissue. In order to achieve this goal various biological products have been introduced, among which are present the platelet concentrates. Platelet concentrates with their higher concentration of platelets has been used in the field of medicine since the 1990s in the form of the first-generation concentrates-Platelet Rich Plasma, and the second generation concentrated -Platelet Rich Fibrin. Choukroun’s Platelet Rich Fibrin is one such material, which is used by itself and also as an adjunct with grafts. It has been successful as it delivers high doses of growth factors and has anti-inflammatory properties. They have been shown to be of great promise in the field of dentistry, ranging from implantology; Sinuses lift procedures, treating of endodontic and periodontal lesions to regeneration of necrotic pulp. T...