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Pharmacoeconomics is a young science that will improve with application. Its need is undeniable, especially in developing countries. Pharmacoeconomics is a sub-discipline of the field of health economics, which itself is a relatively new sub-discipline of economics, only formerly appearing in the economics scientific literature since the 1960s. Accuracy of costeffectiveness estimates depends on the quality of input variables; validity of surrogate end points; and appropriateness of modelling assumptions, including model structure, time horizon and sophistication of the model to differentiate clinically and economically meaningful outcomes. Economic analysis alongside pivotal clinical trials are often inconclusive due to the suboptimal collection of economic data and protocol-driven costs. The two fundamental components of pharmacoeconomic studies are measures of costs and measures of outcomes that are combined into a quantitative measure or ratio. It can be done using various methods like Cost-minimization analysis (CMA), Cost-effectiveness analysis (CEA), Cost-utility analysis (CUA), and Cost-benefit analysis (CBA). Cost involves all the resources that are used to produce and deliver a particular drug therapy. The need for pharmacoeconomic evidence has fundamentally changed the strategic imperatives of research and development (R&D). Therefore, professionals in pharmaceutical R&D have to be familiar with the principles of pharmacoeconomics, including the selection of health policy-relevant comparators, analytical techniques, measurement of health gain by quality adjusted life-years and strategic pricing of pharmaceuticals. Keywords: Pharmacoeconomics, Cost effectiveness analysis, Drug therapy.
Pharmacoeconomics is a subdivision of health economics and result from that discipline coming of age through consolidation to diversification. Health economics, as a branch of economics is itself relatively young. Economics, indeed, there are a still health economist who regards the growth of Pharmacoeconomics as an unnecessary over specialization. As a discipline which is still is the process of growth any definition would become outdated by the time this book is published. Earliest definitions of Pharmacoeconomics are very narrowly focused on the “analysis of the cost of drug therapy to health care systems and society”. This perception of Pharmacoeconomics research is solely concerned with cost and does not consider the outcome from the use of pharmaceutical products. Pharmacoeconomics research is about: “Assessing the implications of projected outcomes and costs of pharmaceutical products for the decision whether to continue or stop development of a drug and for global pricing strategy”. This expanded definition has got the advantage of incorporating Pharmacoeconomics research into the process of drug development from inception (pre phase one) up to phase four when post-marketing surveillance is taking place.
Journal of Clinical Pharmacy and Therapeutics, 2003
British Journal of Clinical Pharmacology, 2013
Value in Health, 1999
Indian Journal of Pharmacy and Pharmacology, 2020
The expenses of health services are expanding in all the nations as the enhancement in and alteration of wellbeing advances every day. Pharmacoeconomics evaluation of clinical trials plays a vital role in assisting clinicians and researchers to take the decision over the economic and clinical outcomes of new health intervention and in helping patients to access new health interventions in affordable expenses. Incorporating pharmacoeconomics into clinical trials offers a clinical research organization to developed, design, and conduct a clinical trial to gain the most reliable data with possible minimum expenses. A literature search was done using Medline electronic database with PubMed. MeSH terms such as ‘Pharmacoeconomics’, Cost-effectiveness Analysis’, ‘Cost-minimization Analysis’, ‘Cost-utility Analysis’, ‘Cost-benefit Analysis’, ‘Health economics’, ‘Quality of Life’, ‘Cost-analysis’, ‘Clinical trials’, ‘Healthcare’ etc. were used. We found that most randomized clinical trials h...
Journal of Clinical Pharmacy and Therapeutics, 2003
This is the second paper in a series looking at pharmacoeconomic methods. The first paper discussed how costs are identified for pharmacoeconomic studies. This article will examine one of the four main evaluation methods in health economics, cost-minimization analysis (CMA). The remaining three methods (cost-effectiveness, costutility and cost-benefit analysis) will be discussed in later papers. Key messages • Cost-minimization is the appropriate form of economic analysis to carry out whenever two drugs have the same clinical effect. • True equivalence studies are uncommon; a more useful approach is to assess the size of the confidence interval around the difference between treatments and determine whether it excludes clinically relevant effects. • The critical issue for cost-minimization analyses is determining equi-effective doses.
Journal of the European Academy of Dermatology and Venereology, 2005
Objectives The first aim of this workshop was to define pharmacoeconomic concepts and terminology. Pharmacoeconomics can be defined as the branch of economics that uses cost-benefit, cost-effectiveness, cost-minimization, cost-of-illness and cost-utility analyses to compare pharmaceutical products and treatment strategies. Economic evaluations provide healthcare decision-makers with valuable information, allowing optimal allocation of limited resources. However, pharmacoeconomics is based on long-term benefits, whereas physicians are typically forced to seek immediate savings. The second aim was to review pharmacoeconomic studies in the field of onychomycosis and finally to discuss future perspectives. Results and Conclusions We discussed current pharmacoeconomic issues on the management of onychomycosis. Consensus was reached on the following issues: • Published pharmacoeconomic studies concerning onychomycosis are flawed. Future studies should be based on internationally validated principles and appropriate models. The fact that costs of different drugs, laboratory examinations and physician visits vary worldwide should be considered. Cost-benefit studies are required. • The National Institute for Clinical Excellence (NICE) recommendations are often considered in countries other than the UK, even when not adapted to the country in question. • Generic drugs might reduce costs, but this depends on their effectiveness (bioavailability). • Sampling requests affect the economic cost (dependent on methodology, which depends on country) and physicians often trust their instincts even when tests are repeatedly negative. • The cost of adverse event management is usually considered to be 10%; this may be too high for onychomycosis, as treatments are relatively safe without severe side-effects. • Probability of recurrence for each drug should be determined. • Need for disease severity standardization, definition of diagnostic criteria and successful treatment (mycological and clinical cure).
Systematic Reviews in Pharmacy, 2019
As a consequence of limited financial resources, health economics, and particularly pharmacoeconomic analyses, are becoming a frequently used criterion for decision making in modern health care policy. The pharmacoeconomic studies cannot be universal and their results are impossible to be directly transferred beyond the study setting. This article draws the readers' attention to the main components of pharmacoeconomic studies, which have an influence on the generalisability of the results. The aim is for the readers to get an idea as to what extent pharmacoeconomic results are correct and how these correspond to their own setting.
2015
The rising cost of healthcare delivery systems is a major concern to all patients, healthcare professionals, and the government. The demand for and the cost of health care are increasing in all countries as the improvement in and sophistication of health technologies. The increase in health care spending is mainly because of increased life expectance, increased technology, increased standard of living and increased demand in health care quality and services. Medicines form a small but significant proportion of total health care cost. As the affordability of new medical technologies continues to be the subject of heated debate, attention is also increasingly focused on providing quality and cost-effective healthcare. Economic evaluation of pharmaceutical products, or pharmacoeconomics, is a rapidly growing area of research. Pharmacoeconomic evaluation is important in helping clinicians and decision makers to make choices about new pharmaceutical products and in helping patients obtai...
British Journal of Clinical Pharmacology, 1997
2013
CITATIONS 0 READS 102 6 authors, including:
Pharmacoeconomics has been defined as the description and analysis of the cost of drug therapy to healthcare systems and society. More specifically, pharmacoeconomic research is the process of identifying, measuring, and comparing the costs, risks, and benefits of programs, services, or therapies and determining which alternative produces the best health outcome for the resource invested. For most practitioners, this translates into weighing the cost of providing a pharmacy product or service against the consequences (outcomes) realized by using the product or service to determine which alternative yields the optimal outcome per dollar spent. This information can assist clinical decision makers in choosing the most cost-effective treatment options.
PharmacoEconomics, 1998
The need to demonstrate the cost effectiveness of healthcare interventions has led to a rapid increase in the use of economic tools within pharmaceutical evaluations. Pharmacoeconomics is employed at many stages of the evaluation process, helping to predict which products are likely to be economically viable at an early stage, and providing information to aid price and reimbursement negotiations as well as formulary and purchasing decisions in conjunction with phase III and IV clinical trials.
PHARMACOECONOMICS: theory and practice, 2016
The increase of practical application of pharmacoeconomics in the organiza- tion of medicinal provision the Russian Federation requires clarification of the definition of the concepts of pharmacoeconomics. Thus, in the context of the academic approach the term «pharmacoeconomics» can be defined as an in- dependent science that studies in comparative terms the ratio between cost and effectiveness, safety and quality of life of patients with different treatment regimens or disease prevention. However, from the perspective of practical ap- plication it will be more accurate to consider pharmacoeconomics as a tool for decision support, providing decision-makers, relevant and reliable information in order to create from them a clear understanding of the situation and the pos- sibility of taking appropriate optimal solutions. Herewith, wide opportunities of pharmacoeconomics are based on the application of pharmacoeconomic mod- eling. In this connection, the authors, based on their own pr...
Procedia Economics and Finance, 2015
By today, in our business environment, mostly based on innovation, the potential opportunities in the pharmaceutical sector and impact of these to the national economic trends has a determining significance. National and international importance of the pharmaceutical industry defined by not only the prominent role of application of the biochemical academic research, but also the humanitarian concerns which increasingly appreciating in the global context. These facts-in view of growing efficient immune substances developing procedures-are stronger pressure on the industrial actors, with this affecting the profitability of future operations. Broader sense pharmacoeconomics includes the examination of the main factors which influence the change of expenditures produced in the health system, furthermore compares the value of different pharmaceutical drugs or drug therapies by using many analytical methods such as cost minimalization analysis, cost benefit analysis, cost effectiveness analysis and the cost utility analysis. Our analysis is mostly theoretical.
Health Economics, 1999
Disease Management and Health Outcomes, 2002
Increased worldwide cost consciousness with regard to healthcare spending has resulted in a greater reliance of health systems on pharmacoeconomics as a tool for obtaining optimal value, attaining better outcomes, and controlling spending. In such capacities, pharmacoeconomics is often used as a basis for pricing, purchasing, and reimbursement decisions. Current barriers to the use of pharmacoeconomic data are related to the international coexistence of various evolutionary states of the theory and implementation of pharmacoeconomics, the fragmentation of healthcare budgets, and the diversity of healthcare systems and clinical settings. One result of these barriers is the decision makers' need for more rigorous, more directly relevant pharmacoeconomic data that are presented in an interactive, customizable manner. Other stakeholders in the healthcare market have been noticeably affected by decision makers' use of pharmacoeconomics and the more stringent data demands. Physicians have experienced decreased autonomy, patients have experienced delayed drug access and possibly compromised care, and manufacturers have endured greater financial burden and risk. This paper identifies ways in which manufacturers can maximize the effectiveness of their pharmacoeconomic activities to efficiently meet decision-maker needs, overcome some of the current barriers to the use of pharmacoeconomics, and minimize deleterious effects on major healthcare stakeholders.
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