A Supramodal Number Representation in Human Intraparietal Cortex

Journal of Neuroscience, 2014

Current Biology, 2004

The parietal cortex is a central part of the brain's system for representing numbers and magnitudes. Activity in the parietal cortex might reflect number representation or actions made in response to the numbers.

Neuron, 2007

Activation of the horizontal segment of the intraparietal sulcus (hIPS) has been observed in various number-processing tasks, whether numbers were conveyed by symbolic numerals (digits, number words) or by nonsymbolic displays (dot patterns). This suggests an abstract coding of numerical magnitude. Here, we critically tested this hypothesis using fMRI adaptation to demonstrate notation-independent coding of numerical quantity in the hIPS. Once subjects were adapted either to dot patterns or to Arabic digits, activation in the hIPS and in frontal regions recovered in a distancedependent fashion whenever a new number was presented, irrespective of notation changes. This remained unchanged when analyzing the hIPS peaks from an independent localizer scan of mental calculation. These results suggest an abstract coding of approximate number common to dots, digits, and number words. They support the idea that symbols acquire meaning by linking neural populations coding symbol shapes to those holding nonsymbolic representations of quantities.

Cerebral Cortex, 2010

Numerous studies have identified the intraparietal sulcus (IPS) as an area critically involved in numerical processing. IPS neurons in macaques are tuned to a preferred numerosity, hence neurally coding numerosity in a number-selective way. Neuroimaging studies in humans have demonstrated number-selective processing in the anterior parts of the IPS. Nevertheless, the processes that convert visual input into a number-selective neural code remain unknown. Computational studies have suggested that a neural coding stage that is sensitive, but not selective to number, precedes numberselective coding when processing nonsymbolic quantities but not when processing symbolic quantities. In Experiment 1, we used functional magnetic resonance imaging to localize number-sensitive areas in the human brain by searching for areas exhibiting increasing activation with increasing number, carefully controlling for nonnumerical parameters. An area in posterior superior parietal cortex was identified as a substrate for the intermediate number-sensitive steps required for processing nonsymbolic quantities. In Experiment 2, the interpretation of Experiment 1 was confirmed with a connectivity analysis showing that a shared number-selective representation in IPS is reached through different pathways for symbolic versus nonsymbolic quantities. The preferred pathway for processing nonsymbolic quantities included the number-sensitive area in superior parietal cortex, whereas the pathway for processing symbolic quantities did not.

NeuroReport, 2005

Brain Stimulation, 2008

A dominant view in numerical cognition is that processing the quantity indicated by numbers (e.g. deciding the larger between two numbers such as '12.07' or '15.02') relies on the intraparietal regions (IPS) of the cerebral cortex. However, it remains unclear whether the IPS could play a more general role in numerical cognition, for example in (1) quantity processing even with non-numerical stimuli (e.g. choosing the larger of 'bikini' and 'coat'); and/or (2) conceptual tasks involving numbers beyond those requiring quantity processing (e.g. attributing a summer date to either '12.07' or '15.02').

Journal of Cognitive Neuroscience, 2008

Annual Review of Neuroscience, 2009

Number symbols have allowed humans to develop superior mathematical skills that are a hallmark of technologically advanced cultures. Findings in animal cognition, developmental psychology, and anthropology indicate that these numerical skills are rooted in nonlinguistic biological primitives. Recent studies in human and nonhuman primates using a broad range of methodologies provide evidence that numerical information is represented and processed by regions of the prefrontal and posterior parietal lobes, with the intraparietal sulcus as a key node for the representation of the semantic aspect of numerical quantity.

Neuropsychologia, 2017

It is currently debated whether numbers are processed using a number-specific system or a general magnitude processing system, also used for non-numerical magnitudes such as physical size, duration, or luminance. Activation likelihood estimation (ALE) was used to conduct the first quantitative meta-analysis of 93 empirical neuroimaging papers examining neural activation during numerical and non-numerical magnitude processing. Foci were compiled to generate probabilistic maps of activation for non-numerical magnitudes (e.g. physical size), symbolic numerical magnitudes (e.g. Arabic digits), and nonsymbolic numerical magnitudes (e.g. dot arrays). Conjunction analyses revealed overlapping activation for symbolic, nonsymbolic and non-numerical magnitudes in frontal and parietal lobes. Contrast analyses revealed specific activation in the left superior parietal lobule for symbolic numerical magnitudes. In contrast, small regions in the bilateral precuneus were specifically activated for ...

Cognitive Brain Research, 2004

Numbers convey different meanings when used in different contexts . In a cardinal context, a number will tell us how many entities are in a set and convey quantity meaning. In an ordinal context, a number will refer to the relative position (or rank) of one element within a sequence; non-numerical ordered series (e.g. the letters of the alphabet) can also be used to provide meaningful order information. Because quantity and order are linked up with each other in the cognitive number domain (the larger the quantity a number refers to, the later it is located in the conventional number sequence), the question of whether they rely on some common or distinct underlying mechanism(s) is theoretically relevant and was addressed in the present thesis. Experimental studies showed evidence of both similarities (similar distance and SNARC effects, recruitment of parietal and frontal regions, and conjoint impairment or preservation after brain damage) and dissociations (different developmental course, dissociation after cerebral lesion, and specific behavioural markers) between quantity and order neuro-functional processes. The aim of the present thesis was to clarify the relationship between numerical quantity and order processing and to test the hypothesis that they rely on (at least partially) dissociated mechanisms. We tested this hypothesis in a single case study, an electrophysiological study and in two behavioural experiments. In the neuropsychological study, we reported the case of patient CO, who showed Gerstmann syndrome after bilateral parietal damage and beca...