Dermacase. Sweet syndrome

Bangladesh Journal of Child Health

Sweet syndrome (SS) is a rare dermatosis of unknown etiology. It is characterized by fever, neutrophilia, raised and painful plaques on the skin of the face, neck, limbs, and histologically by dermal infiltration of neutrophils. Here, we present a ten-year-old boy who presented with fever and multiple skin lesions for 15 days. On examination, he was febrile and presented with multiple nodular, tender, erythematous rash on face and limbs. Laboratory findings revealed raised inflammatory markers with neutrophilic leukocytosis, skin biopsy showed hyperkeratosis and neutrophilic infiltration of the dermis. Typical history, laboratory investigations including skin biopsy findings were suggestive of diagnosis of SS. Prolonged fever and characteristics skin lesions in any child should be suspected for this rare syndrome. It should be kept in mind as a differential diagnosis in the day-today clinical practice for effective management of this rare disease. BANGLADESH J CHILD HEALTH 2021; VOL...

The Mediterranean Journal of Emergency Medicine, 2017

Introduction: Skin disorders are common in emergency department especially when associated with fever. Twenty five to forty percent are related to a decompensation of a preexisting skin disease . In 1964, Sweet describes a "strange eruption" which is immunologically mediated and since that date the dermatitis bears his name . In the emergency department, the diagnosis of this pathology may be difficult especially when the presentation is severe or associated with fever since it face the physician to a therapeutic dilemma: giving antibiotics or steroids. Case presentation: A 43 years old man with no past medical history was transported to the emergency department by the mobile emergency service with a chief complaint of weakness and fever associated with a disseminated skin eruption. He was conscious but very weak and he has fever about 38.5°C. Systolic blood pressure/diastolic blood pressure was about 90/60 mmHg and heart rate about 96 per minute. Initially he was managed as severe septic syndrome since we found nitrites in urine sample associated with systemic inflammatory response syndrome (SIRS). A PCT was performed and the amount was less than 0.5 ng.mL -1 so we performed a skin biopsy which showed a neutrophilic infiltration consistent with Sweet syndrom. The patient was given steroids and had rapid improvement of his complaints. Sweet syndrome is a possible diagnostic in patient with skin eruption and non infectious SIRS in the emergency department

International journal of dermatology, 2010

Sweet's syndrome (SS) is an uncommon disorder characterized by the abrupt onset of erythematous papules and plaques that histologically exhibit diffuse dermal neutrophilic infiltrate and edema. There are usually associated constitutional symptoms such as fever, neutrophilia, elevated serum inflammatory markers, and associated disorders. The aim of this study was to assess the clinical and histologic features of all patients diagnosed with SS at our institution between 1971 and 2008 and to compare their findings with those published in the literature. Retrospective review of 44 cases of SS diagnosed at the American University of Beirut - Medical Center between 1971 and 2008. Data collected included clinical (age, gender, morphology and distribution of lesions, associated symptoms and disorders, therapy) and histologic features, as well as laboratory abnormalities. Most of our patients showed the typical clinical, histologic, and laboratory abnormalities characteristic of SS. Of o...

Current Health Sciences Journal, 2020

Introduction. Sweet syndrome (SS), also denominated as acute febrile neutrophilic dermatosis, is a rare disease characterized by the sudden onset of painful, erythematous, firm skin lesions (papules, plaques, and nodules) which show, upon histologic examination, the presence of a diffuse infiltrate of mature neutrophils. The cutaneous manifestation typically involves the face, neck, trunk, and upper limbs and is associated with fever, general malaise, arthralgia. Case report. A female patient, 60 years old, attended the Dermatology Clinic due to the appearance of violaceous erythematous-oedematous infiltrated plaques, located on the face, neck, upper limbs, trunk and knees. The onset of the cutaneous manifestation had occurred 2 months prior, accompanied by pain, chills, flares of fever and arthralgia. The onset coincided with the surgical treatment of an umbilical hernia. From the medical history we note that the patient was diagnosed in 2014 with histiocytoid SS. She followed a tr...

Baylor University Medical Center Proceedings, 2021

We present a rare case of Sweet’s syndrome. A 39-year-old woman with subjective fevers, polyarthralgia, and malaise presented with worsening painful erythematous plaques on the trunk, arms, and legs. Further examination with biopsy revealed a diagnosis of acute febrile neutrophilic dermatosis, or Sweet’s syndrome. Diagnosis by skin biopsy is crucial, and onset requires prompt evaluation for serious associated disorders such as leukemias, inflammatory bowel disease, thyroid disease, sarcoidosis, and infectious etiologies. In general, symptoms and cutaneous manifestations of Sweet syndrome respond rapidly to treatment with systemic corticosteroids or potassium iodide.

Clinical Medicine & Research, 2011

11 yrs female, 2nd issue of non-consanguineous marriage with H/O Joint Pain & swelling since 8 months, fever since 4 days was admitted with us. Patient was investigated and treated symptomatically. Peripheral smear showed dense neutrophilia. Skin biopsy confirmed the final diagnosis of ?Sweet Syndrome?. Symptoms relieved dramatically after MethylPrednisolone Pulse Therapy

European Journal of Clinical Medicine

Sweet syndrome is an uncommon disorder of unknown etiology and characterized by skin and systemic inflammation. Classic Sweet syndrome is not associated with malignancy or drug exposure and typically involves elderly females. A 67-year-old female with a past medical history of multiple sclerosis and chronic kidney disease presented with worsening erythema of bilateral lower extremities, and diffuse, tender pustular lesions in her extremities, eye lids, nares, oral commissures, and tongue. A biopsy revealed marked neutrophilic inflammation suggestive of Sweet syndrome and she was started on high dose methylprednisolone which immediately improved her condition. As with most progressive inflammatory diseases, early recognition and early treatment improves the prognosis. This case is unusual because of mucosal involvement at presentation. Classic Sweet syndrome can often be diagnosed by exclusion after failed treatment for either infectious or autoimmune disorders.

Journal of Investigative Medicine High Impact Case Reports

Sweet’s syndrome, also known as acute febrile neutrophilic dermatosis, is a rare disorder that typically presents with rapid appearance of tender skin lesions accompanied by fever and leukocytosis with neutrophilia. Its pathogenesis is not fully understood. The syndrome is generally classified into classical, malignancy-associated, and drug-induced categories, each of which has its specific characteristics. In this article, we present a case of classical Sweet’s syndrome in a woman who presented with an acute viral illness.

International Journal of Homoeopathic Sciences, 2021

Sweet syndrome aka acute febrile neutrophilic dermatosis is one of the serious dermatological condition which goes undiagnosed due to several reasons. Unawareness of this condition may be one of the primary factors for missing the diagnosis which may lead to inaccurate treatment which may only lead to worsening the condition in a sick individual. Very few studies have been published in this area, hence the present investigator felt the need of reviewing few literatures and creating a material which will aid in early and accurate diagnosis of the condition. About 20 literature was reviewed based on the history, presentation, diagnosis and its probable homoeopathic treatment accordingly. All the information required for accurate diagnosis and its homeopathic approach was compiled into the present paper.