Severe Tinnitus and Depressive Symptoms: A Complex Interaction

Otolaryngology -- Head and Neck Surgery, 2011

Objective. In this study, the authors investigated whether tinnitus severity is a problem related to depression. If so, the following 2 conditions should be fulfilled: first, there should be evidence for the presence of moderate to severe depressive symptomatology in a substantial group of tinnitus patients; second, there should be evidence of a substantial relationship between depressive symptoms and tinnitus severity.

Otolaryngology-Head and Neck Surgery, 2011

Objective. In this study, the authors investigated whether tinnitus severity is a problem related to depression. If so, the following 2 conditions should be fulfilled: first, there should be evidence for the presence of moderate to severe depressive symptomatology in a substantial group of tinnitus patients; second, there should be evidence of a substantial relationship between depressive symptoms and tinnitus severity.

Otolaryngology -- Head and Neck Surgery, 2011

Brazilian Journal of Otorhinolaryngology, 2013

Ti nnitus has been associated with several psychiatric disorders, however there are still several questions regarding such association. Objective: To assess the scientific evidence on the associations between symptoms of depression, depression, and tinnitus. Method: A systematic review was performed using PubMed, Lilacs, and SciELO scientific databases. This review included studies published in Portuguese, Spanish, or English correlating tinnitus with depression; letters to the editor and case reports were excluded. Results: A total of 64 studies were identified, of which only 20 met the inclusion criteria and only 2 were case-control clinical trials. The majority of the studies (n = 18) found that depression is associated with tinnitus, either as a predisposition-resulting in poor adaptation to tinnitus or as a consequence of severe disease. Conclusion: An overall assessment of all of the selected studies suggests at least 3 possible associations between depression and tinnitus: depression affecting tinnitus, tinnitus predisposing individuals to depression, and tinnitus appearing as a comorbidity in patients with depression. There is a high prevalence of depressive symptoms in individuals with tinnitus, but the mechanisms by which depression and tinnitus mutually interact, are not fully understood.

Clinical and investigative medicine. Medecine clinique et experimentale, 2016

The aim of the study was to investigate the correlation between THI (Tinnitus Handicap Inventory) and BDS (Beck Depression Scale). High frequency thresholds and PTA (Pure Tone Audiometer) thresholds for the patients were measured in 44 patients with tinnitus (bilateral=13; unilateral=31). Tinnitus frequency and intensity were measured using one-pair method with high frequency audiometer Interacoustic AC40. Applied BDS and THI scores are evaluated for all patients. Our findings are analysed statistically with SPSS v.21 and BDS and THI correlation with tinnitus intensity and frequency was executed. The mean value of tinnitus frequency was 10 kHz (min 0.25 kHz, max16 kHz and SD 4.26), mean tinnitus intensity was 50.6 dB (min 15 dB, max 110 dB and SD 26.9 dB) mean THI score was 38.04 (min 10, max 86 and SD 20.03) and mean BDS score was 9.45 (min 0, max 28 and SD 6.49). There was no statistical correlation between THI score and tinnitus frequency (r=0.055, p=0.787). Moderate correlation ...

Frontiers in Neurology, 2022

Results: We found that the overall incidence rate for MDD was 0.78 (95% CI = 0.76∼0.80) per 100 person-years, being 1.17 (95% CI = 1.14∼1.21) among the study cohorts and 0.38 (95% CI = 0.36∼0.40) among the comparison cohorts. The log-rank test revealed that the patients in the study cohort had significantly lower one-year MDD-free survival when compared to the comparison cohort (p < 0.001). Cox proportional hazards analysis showed that the patients in the study cohort had a higher hazard of developing MDD than the patients in the comparison cohort (adjusted HR = 3.08, 95% CI = 2.90∼3.27). Conclusions: In this study, we demonstrate that tinnitus is associated with an increased hazard of subsequent MDD in Taiwan.

Journal of Psychosomatic Research, 2010

Clinical studies indicate a strong association between tinnitus and mental health, but results from general population data are missing. The purpose of the study was to examine the association between tinnitus, mental health, and wellbeing in the general adult population and to identify factors that might mediate and moderate this association. Methods: Data from 51,574 adults participating in the Nord-Trøndelag Hearing Loss Study (1995)(1996)(1997), part of the Nord-Trøndelag Health Study (HUNT-2), were analyzed. The association between tinnitus symptom intensity and symptoms of depression, anxiety, selfesteem, and subjective well-being was examined by multivariate ANOVA, stratified by age group and sex. Explanatory variables were age, marital status, education, hearing, dizziness, vision, physical disability, and somatic illness. In a subsample of participants with tinnitus, the effects of "time since onset," "predictability of tinnitus episodes," and "noise sensitivity" were tested. Results: Participants with tinnitus scored significantly higher on anxiety and depression and lower on self-esteem and well-being than people without tinnitus. The effect sizes were small and quite similar across levels of tinnitus symptom intensity. No significant effect of time since onset was found. A significant effect of predictability of tinnitus episodes and noise sensitivity was found in some groups. Conclusion: A weak association between tinnitus and mental health was found in this general population study.

PLoS ONE, 2012

Tinnitus, the perception of sound without external source, is a highly prevalent public health problem with about 8% of the population having frequently occurring tinnitus, and about 1-2% experiencing significant distress from it. Population studies, as well as studies on self-selected samples, have reported poor psychological well-being in individuals with tinnitus. However, no study has examined the long-term co-variation between mood and tinnitus prevalence or tinnitus severity. In this study, the relationship between depression and tinnitus prevalence and severity over a 2-year period was examined in a representative sample of the general Swedish working population. Results show that a decrease in depression is associated with a decrease in tinnitus prevalence, and even more markedly with tinnitus severity. Hearing loss was a more potent predictor than depression for tinnitus prevalence, but was a weaker predictor than depression for tinnitus severity. In addition, there were sex differences for tinnitus prevalence, but not for tinnitus severity. This study shows a direct and longterm association between tinnitus severity and depression.

World Journal of Biological Psychiatry, 2011

Objectives. Depressive symptoms are common in individuals with tinnitus and may substantially aggravate their distress. The mechanisms, however, by which depression and tinnitus mutually interact are still not fully understood. Methods. Here we review neurobiological knowledge relevant for the interplay between depression and tinnitus. Results. Neuroimaging studies confi rm the existence of neural circuits that are activated both in depression and tinnitus. Studies of neuroendocrine function demonstrate alterations of the HPA-axis in depression and, more recently, in tinnitus. Studies addressing neurotransmission suggest that the dorsal cochlear nucleus that is typically hyperactive in tinnitus, is also involved in the control of attention and emotional responses via projections to the locus coeruleus, the reticular formation and the raphe nuclei. Impaired hippocampal neurogenesis has been documented in animals with tinnitus after noise trauma, as in animal models of depression. Finally, from investigations of human candidate genes, there is some evidence to suggest that variant BDNF may act as a common susceptibility factor in both disorders. Conclusions. These parallels in the pathophysiology of tinnitus and depression argue against comorbidity by chance and against depression as pure reaction on tinnitus. Instead, they stand for a complex interplay between tinnitus and depression. Implications for tinnitus treatment are discussed.

International Tinnitus Journal, 2013

The present study investigated the relationship between the perceived tinnitus severity, depressive and anxiety symptoms in individuals with tinnitus. An attempt was also made to see if any relationship exists between the perceived tinnitus severity and the age, gender or hearing status of the sufferer. Materials and Methods: Fifty individuals (31 males, 19 females) with tinnitus (age range 19 to 60 years) were enrolled in the study. After the routine pure tone audiometry, each participant completed the Tinnitus Handicap Inventory, the State-Trait Anxiety Inventory and the Inventory of Depressive Symptomatology-Self Report-30. Results: A significant correlation (r = 0.585, p < 0.01) was found between the perceived tinnitus severity, as indicated by the Tinnitus Handicap Inventory scores and depressive symptoms. Tinnitus Handicap Inventory scores also correlated significantly with both state and trait anxiety levels (r = 0.602, p<0.01; r = 0.426, p < 0.01 respectively). Furthermore, age, gender and hearing status did not significantly influence the perceived severity of tinnitus. Conclusion: The results support the view that there is a strong relation between tinnitus and anxiety-depressive symptoms. Further, perceived severity of tinnitus is not influenced by age, gender and hearing status of the individual.