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2020, Intensive Care Medicine
Critical Care
Technologies and Applications for Big Data Value
Computer systems deployed in hospital environments, particularly physiological and biochemical real-time monitoring of patients in an Intensive Care Unit (ICU) environment, routinely collect a large volume of data that can hold very useful information. However, the vast majority are either not stored and lost forever or are stored in digital archives and seldom re-examined. In recent years, there has been extensive work carried out by researchers utilizing Machine Learning (ML) and Artificial Intelligence (AI) techniques on these data streams, to predict and prevent disease states. Such work aims to improve patient outcomes, to decrease mortality rates and decrease hospital stays, and, more generally, to decrease healthcare costs.This chapter reviews the state of the art in that field and reports on our own current research, with practicing clinicians, on improving ventilator weaning protocols and lung protective ventilation, using ML and AI methodologies for decision support, inclu...
Communications Medicine
Background Despite apparent promise and the availability of numerous examples in the literature, machine learning models are rarely used in practice in ICU units. This mismatch suggests that there are poorly understood barriers preventing uptake, which we aim to identify. Methods We begin with a qualitative study with 29 interviews of 40 Intensive Care Unit-, hospital- and MedTech company staff members. As a follow-up to the study, we attempt to quantify some of the technical issues raised. To perform experiments we selected two models based on criteria such as medical relevance. Using these models we measure the loss of performance in predictive models due to drift over time, change of available patient features, scarceness of data, and deploying a model in a different context to the one it was built in. Results The qualitative study confirms our assumptions on the potential of AI-driven analytics for patient care, as well as showing the prevalence and type of technical blocking fa...
Imagine an Intensive Care Unit (ICU) that senses danger before it strikes, predicts patient needs before symptoms manifest, and connects rural hospitals with world-class specialists in real time. The predictive AI-driven ICU is no longer a concept of science fiction but a paradigm shift in critical care. This paper unveils how futuristic medicine architecture combines predictive algorithms, adaptive spaces, and virtual technology to redefine critical care delivery. Framed through the philosophy of Dynamic Resilience in Medicine Architecture (DRMA), it argues for a new ICU model where architecture and artificial intelligence converge to save lives, heal minds, and democratize healthcare access.
IEEE Spectrum, 2018
Bosnian journal of basic medical sciences / Udruženje basičnih mediciniskih znanosti = Association of Basic Medical Sciences, 2009
Medical Informatics has become an important tool in modern health care practice and research. In the present article we outline the challenges and opportunities associated with the implementation of electronic medical records (EMR) in complex environments such as intensive care units (ICU). We share our initial experience in the design, maintenance and application of a customized critical care, Microsoft SQL based, research warehouse, ICU DataMart. ICU DataMart integrates clinical and administrative data from heterogeneous sources within the EMR to support research and practice improvement in the ICUs. Examples of intelligent alarms -- "sniffers", administrative reports, decision support and clinical research applications are presented.
Anaesthesia Critical Care & Pain Medicine, 2020
2010
Modern hospitals are equipped with sophisticated monitoring equipment that displays enormous volumes of raw data about the cardiopulmonary and neural functions of patients. The latest generation of bedside monitors attempts to present these data to the clinician in an integrated fashion to better represent the overall physiological condition of the patient. However, none of these systems are capable of extracting potentially important indices of pattern variability inherent within biological signals. This review has three main objectives. (1) To summarize the current state of data acquisition in the intensive care unit and identify limitations that must be overcome to achieve the goal of real-time processing of biological signals to capture subtleties identifying "early warning signals" hidden in physiologic patterns that may reflect current severity of the disease process and, more importantly, predict the likelihood of adverse progression and death or improvement and resolution. (2) To outline our approach to analyzing biological waveform data based on work in animal models of human disease. (3) To propose guidelines for the development, testing and implementation of integrated software and hardware solutions that will facilitate the novel application of complex systems approaches to biological waveform data with the goal of risk assessment.
Web of science[Bulletin of Environment, Pharmacology and Life Sciences], 2022
In the modern-day world, patients with critical conditions get monitored in the intensive care units in which every condition of the patient is monitored and necessary treatment is taken in a timely. These patients are susceptible to many diseases and that’s why many of their important and damaged organs are taken special care of. To provide such an amount of care to a single patient, much of the staff is required on a single patient for 24 hours. Due to such an amount of care, a lot of useful data is generated which can play an important role to understand many important factors which get ignored usually. To make sense of such large data on paper for a doctor is a very difficult task that can consume a lot of time and still we don’t know the analyzed finding are correct or not. To detect high risks and failure of the organs, machine learning can play an important role to detect such events and actions can be taken place promptly. In this paper, findings from a lot of research papers have been discussed and summarized to give the best possible solution. The goal of this research article is to give useful insights that can improve the already available models. Keywords: Patient Monitoring System, Artificial Intelligence, Intensive Care Unit (ICU)
Intensive Care Medicine
Intensive Care Medicine
Treatment of respiratory failure has improved dramatically since the polio epidemic in the 1950s with the use of invasive techniques for respiratory support: mechanical ventilation and extracorporeal respiratory support. However, respiratory support is only a supportive therapy, designed to "buy time" while the disease causing respiratory failure abates. It ensures viable gas exchange and prevents cardiorespiratory collapse in the context of excessive loads. Because the use of invasive modalities of respiratory support is also associated with substantial harm, it remains the responsibility of the clinician to minimize such hazards. Direct iatrogenic consequences of mechanical ventilation include the risk to the lung (ventilator-induced lung injury) and the diaphragm (ventilator-induced diaphragm dysfunction and other forms of myotrauma). Adverse consequences on hemodynamics can also be significant. Indirect consequences (e.g., immobilization, sleep disruption) can have devastating long-term effects. Increasing awareness and understanding of these mechanisms of injury has led to a change in the philosophy of care with a shift from aiming to normalize gases toward minimizing harm. Lung (and more recently also diaphragm) protective ventilation strategies include the use of extracorporeal respiratory support when the risk of ventilation becomes excessive. This review provides an overview of the historical background of respiratory support, pathophysiology of respiratory failure and rationale for respiratory support, iatrogenic consequences from mechanical ventilation, specifics of the implementation of mechanical ventilation, and role of extracorporeal respiratory support. It highlights the need for appropriate monitoring to estimate risks and to individualize ventilation and sedation to provide safe respiratory support to each patient.
Galician Medical Journal
Introduction. The intensive care unit (ICU) plays a pivotal role in providing specialized care to patients with severe illnesses or injuries. As a critical aspect of healthcare, ICU admissions demand immediate attention and skilled care from healthcare professionals. However, the intricacies involved in this process necessitate analytical solutions to ensure effective management and optimal patient outcomes. Aim. The aim of this review was to highlight the enhancement of the ICUs through the application of analytics, artificial intelligence, and machine learning. Methods. The review approach was carried out through databases such as MEDLINE, Embase, Web of Science, Scopus, Taylor & Francis, Sage, ProQuest, Science Direct, CINAHL, and Google Scholar. These databases were chosen due to their potential to offer pertinent and comprehensive coverage of the topic while reducing the likelihood of overlooking certain publications. The studies for this review involved the period from 2016 to...
International Journal of Reconfigurable and Embedded Systems (IJRES), 2023
Intensive care unit deals with data that are dynamic in nature like real time measurement of health condition to laboratory test data that are continuously changes accordingly with time. Artificial intelligence (AI's) potential ability to perform complex pattern analyses using large volumes of data. Generated pattern discovers the new symptoms of the disease in the Intensive care units (ICUs), helps the doctors to prescribe the new drug discovery which is helpful to intelligent use. Currently research work has been focused in the ICU making more efficient clinical workflow by generation of high-risk patterns from improved high volumes of data. Emerging area of AI in the ICU includes mortality prediction, uses of powerful sensors, new drug discovery, prediction of length of stay and legal role in uses of drugs for severity of disease. This review focuses latest application of AI drugs and other relevant issues for the ICU.
Finnish Journal of eHealth and eWelfare, 2021
The Envision project aims at developing artificial intelligence-based tools for supporting the treatment of critically ill COVID-19 patients in the intensive care unit. Twelve European hospitals participate in the collection of patient data for the development and validation of the artificial intelligence tools. Ten potential use cases have been identified as development targets. Data analysis and results from expert interviews are applied to define the clinically most relevant parameters and functional use cases to be used in providing decision support for the clinicians in the intensive care units for this patient group. The resulting artificial intelligence-based tool may be beneficial in the management of the next similar epidemics, as well.
Intensive Care Medicine, 2020
ArXiv, 2018
Currently, many critical care indices are repetitively assessed and recorded by overburdened nurses, e.g. physical function or facial pain expressions of nonverbal patients. In addition, many essential information on patients and their environment are not captured at all, or are captured in a non-granular manner, e.g. sleep disturbance factors such as bright light, loud background noise, or excessive visitations. In this pilot study, we examined the feasibility of using pervasive sensing technology and artificial intelligence for autonomous and granular monitoring of critically ill patients and their environment in the Intensive Care Unit (ICU). As an exemplar prevalent condition, we also characterized delirious and non-delirious patients and their environment. We used wearable sensors, light and sound sensors, and a high-resolution camera to collected data on patients and their environment. We analyzed collected data using deep learning and statistical analysis. Our system performe...
Journal of Intensive Care …, 2004
Health care information systems have the potential to enable better care of patients in much the same manner as the widespread use of the automobile and telephone did in the early 20th century. The car and phone were rapidly accepted and embraced throughout ...
Critical care medicine, 2011
Objective We sought to develop an intensive care unit research database applying automated techniques to aggregate high-resolution diagnostic and therapeutic data from a large, diverse population of adult intensive care unit patients. This freely available database is intended to support epidemiologic research in critical care medicine and serve as a resource to evaluate new clinical decision support and monitoring algorithms. Design
Critical Care Clinics, 1996
The computer and its accouterments are changing the standard of critical care. Like previous technologic advances, the computer began as a curiosity, and enjoyed both unalloyed but overly quick praise and disdain, eventually emerging as a necessary tool. Like other technologic advances, computer use raises a cluster of new ethical issues. This is true in critical care medicine in particular, but it is also the case throughout medicine and the other health sciences. These ethical issues are addressed infrequently, and only recently has there been any movement toward a sustained disc~ssion.'~ All major technologic advances raise ethical issues. From hemodialysis and mechanical ventilation to artificial organs and genetic engineering, the recent history of medicine has been fueled by the engines of invention and scrutinized by the tools of ethics. This article offers some of this scrutiny in the domain of critical care computing. Not all of the ethical issues that arise in critical care computing are unique to it. Many of these issues surface in other areas as well. For instance, safeguarding data from inappropriate access and predicting outcomes are issues that have emerged throughout the field of medical informatics. Furthermore, critical care units (CCUs) rarely are autonomous entities. Links between and among CCUs, emergency departments, trauma centers, and other departments reveal extensive networks
IEEE Access
Mean arterial pressure (MAP) is an important clinical parameter to evaluate the health of critically ill patients in intensive care units. Thus, the real time clinical decision support systems detecting anomalies and deviations in MAP enable early interventions and prevent serious complications. The stateof-the-art decision support systems are based on a three-phase method that applies offline training, transfer learning, and retraining at the bedside. Their applicability in critical care units is challenging with delay and inaccuracy. In this article, we propose a real time clinical decision support system forecasting the MAP status at the bedside using a new machine learning structure. The proposed system works in real time at the bedside without requiring the offline phase for training using large datasets. It thereby enables timely interventions and improved healthcare services. The proposed machine learning structure includes two stages. Stage I applies online learning using hierarchical temporal memory (HTM) to enable real time stream processing and provides unsupervised predictions. To the best of our knowledge, this is the first time it is applied to medical signals. Stage II is a long short-term memory (LSTM) classifier that forecasts the status of the patient's MAP ahead of time based on Stage I stream predictions. We perform a thorough performance evaluation of the proposed system and compare it with the state-of-the-art systems employing logistic regression (LR). The comparison shows the proposed system outperforms LR in terms of the classification accuracy, recall, precision, and area under the receiver operation curve (AUROC). INDEX TERMS Clinical decision support, classification, hierarchical temporal memory (HTM), long short-term memory (LSTM), machine learning, real time prediction.
Critical care medicine, 2011
Informatics, 2021
Modern Intensive Care Units (ICUs) provide continuous monitoring of critically ill patients susceptible to many complications affecting morbidity and mortality. ICU settings require a high staff-to-patient ratio and generates a sheer volume of data. For clinicians, the real-time interpretation of data and decision-making is a challenging task. Machine Learning (ML) techniques in ICUs are making headway in the early detection of high-risk events due to increased processing power and freely available datasets such as the Medical Information Mart for Intensive Care (MIMIC). We conducted a systematic literature review to evaluate the effectiveness of applying ML in the ICU settings using the MIMIC dataset. A total of 322 articles were reviewed and a quantitative descriptive analysis was performed on 61 qualified articles that applied ML techniques in ICU settings using MIMIC data. We assembled the qualified articles to provide insights into the areas of application, clinical variables u...
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