Introduction: The term collodion baby refers to a clinical entity noted in newborns who are enmeshed by a translucent, corni-fied substance like sheets of uni-form texture so called (collodion membrane) which gives the whole body surface a varnished appear-ance. Although, some other dis-eases and conditions may lead to collodion membrane formation, in almost all the cases the cause is an autosomal recessive ichthyosi-form disease. Case Presentation: The first three cases are all from a consanguine-ously married couple of Fulani decent. The abnormal appearances of the babies' skin were all no-ticed at birth. Parents are first cousins. The last case is a female born at GA of 40wks through emergency caesarian section due to poor progress of labor. She was admitted into the Newborn with abnormal skin. These series are crucial so as to enable the pediatrician have a high index of suspicion of its existence and to be equipped with the skills to tackle the numerous complica-tions that ...
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