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2019, Expert Opinion on Therapeutic Patents
Introduction: Seabuckthorn (SBT) has received worldwide attention for therapeutic, nutraceutical and cosmetic purposes. It is used for the treatment of a number of diseases. Hundreds of commercial products containing SBT are available in the market. Areas covered: This review article covers patents on the therapeutic potential of SBT and its chemical constituents. The therapeutic areas covered in this review include cancer, cardiovascular, diabetes, inflammation, anti-oxidant, and anti-microbial. The patents were searched through Sci-finder, Espacenet, Google Patent, and US Patent. Expert opinion: Plant-based drugs have played an important role in the modern drug industry. Since ancient times, SBT has been used to cure several ailments. SBT has emerged as an important plant, which has been investigated for numerous pharmacological properties and shown to be beneficial in a number of therapeutic areas. Several clinical trials have demonstrated the therapeutic potential of SBT for the treatment of many diseases including cardiovascular, inflammation, diabetes, platelet inhibition, etc. There is huge potential for developing standardized herbal products from different parts of SBT.
IRJMETS Publication, 2021
Seabuckthorn (Hippophae sp.) is a wonderful plant found in the Himalayan region with multiple pharmacological and commercial benefits. This deciduous shrub in the family Elaeagnaceae has been used over centuries as food and traditional medicine especially skin treatment. It consists of various nutrients and bioactive substances such as vitamins, carotenoids, flavonoids, polyunsaturated fatty acids, free amino acids and elemental components etc. There are several areas of research in modern medicine about the usage of seabuckthorn as an aid to patients undergoing cancer therapy; a long-term therapy for reduction of cardiovascular risk factors; cure of gastrointestinal ulcers; internal and therapy for a variety of skin conditions, and as a liver protecting agent and a remedy for liver cirrhosis. Although much study is still needed to explain the mechanism of curing these conditions in molecular and cellular levels, this species shows a huge prospective in the field of medicine to nutrition to cosmetic industry. In Nepal, Seabuckthorn not only aid as a way to protect medicinal and nutritional plants but also preserves biodiversity as well as generates sustainable income source for local people.
Biochemistry, 2022
Sea Buckthorn (Hippophae rhamnoides) has a long history of use as food and medicine in Tibet and Northern Asia, where the plant has been associated with a wide range of health benefits. Sea buckthorn (SB) berry, seed and leaf have been reported to contain more than 190 bioactive compounds, including polyphenols (epicatechin, epigallocatechin, gallic acid, proanthocyanidins, chloregenic acid) and flavonoids (quercetin, isorhamnetin, kampferol glycosides, lutoelin, myricetin). SB represents a good source of phenolic compounds and flavonoids acting in synergy with PUFA such as omegas 3, 6, 7 and 9, vitamins (vitamin C), and organic acids. SB exerts antioxidant, anti-inflammatory, cytoprotective, anti-cancer, hepatoprotective properties, associated with improvement in various metabolic markers such as glycemic control and lipid profile. SB polyphenol fraction also demonstrated significant cardioprotective, antihypertensive and neuroprotective actions. SB acts as a natural stem cell mobilizer associated with significant regenerative properties. As a consequence, SB polyphenol consumption stimulates pancreatic regeneration in animal model of insulin-dependent diabetes. In conclusion, SB polyphenols exert a wide range of health benefits in metabolic health including obesity, diabetes and hypertension, as well as liver, kidney and brain health, positioning sea buckthorn berry extract as an interesting and valuable dietary supplement for natural complementary therapy and for antiaging.
2014
In this paper, we briefly described the contents, types, extraction methods and medical value of Seabuckthorn flavonoids.
2006
Introduction Herbs, in fact, represent one of the first pharmacological inventions attempted by the healer and it also forms the basis of the modern system besides being sheet anchor of ancient Indian system of medicine. Indian geography is rich for its biodiversity of medicinal herbs particularly the Indian Himalayas. But these medicinal plants species decline very rapidly in last few decayed. The World Health Organization has also recommended to actively promote the use of natural medicines based on their beneficial effect and also to initiate steps to cultivate and conserve the medicinal plants. Indian subcontinent, especially the northwestern Himalayan region, is endowed with the richest experties in traditional medicine. “Seabuckthorn” is one of the prime medicinal plants inhabiting dry temperate region of Himachal Pradesh and adjoining areas of Ladakh. Seabuckthorn is widely prevalent in dry temperate Himalayan region. Indian Himalayas have been the second or third richest res...
2015
Background and aims: Sea buckthorn (Hippophae rhamnoides L.) is a deciduous plant and has highly variable type and size, from small shrubs to medium-sized trees, traditionally growing in Tibet and currently all over the world especially in Europe and Asia. This study aimed to overview some of therapeutic and non-therapeutic properties of SBT and its potential benefits and side effects in order to open up a clear understanding for further detailed study in this regard. Methods: This review article was carried out by searching studies in Web of Science, Google Scholar, PubMed and ScienceDirect. The search terms were “Sea buckthorn”, “Sea buckthorn” and “hippophae”, “therapeutic”, “non-therapeutic”. Results: Various studies have shown that sea buckthorn plays a role in the treatment of cardiovascular disease, liver fibrosis, skin diseases (eczema, acne,), arthritis, vaginal atrophy, dry eye. This herb has anti- inflammatory, anti-constipation, antioxidant, anti-aging, anti-cancer, anti...
Journal of Applied Phycology, 2004
In the last three decades the discovery of metabolites with biological activities from macroalgae has increased significantly. However, despite the intense research effort by academic and corporate institutions, very few products with real potential have been identified or developed. Based on Silverplatter MEDLINE and Aquatic Biology, Aquaculture & Fisheries Resources databases, the literature was searched for natural products from marine macroalgae in the Rhodophyta, Phaeophyta and Chlorophyta with biological and pharmacological activity. Substances that currently receive most attention from pharmaceutical companies for use in drug development, or from researchers in the field of medicine-related research include: sulphated polysaccharides as antiviral substances, halogenated furanones from Delisea pulchra as antifouling compounds, and kahalalide F from a species of Bryopsis as a possible treatment of lung cancer, tumours and AIDS. Other substances such as macroalgal lectins, fucoidans, kainoids and aplysiatoxins are routinely used in biomedical research and a multitude of other substances have known biological activities. The potential pharmaceutical, medicinal and research applications of these compounds are discussed.
The Pharma Innovation Journal, 2021
This review is result of various research and studies of comprehensive material regarding nutritional composition, biological activities as well as uses of sea buckthorn as food, medicine, cosmeceuticals, and feed. Sea buckthorn holds unique nutritional composition with Vitamins (A, C, D, E, F, K, P, and B complex vitamins), 18 free amino acid and unique unsaturated fatty acid profile that makes berry only plant source of omega- 7 fatty acid. Its bioactive phytochemical compounds possess various biological activity such as antioxidant activity, immunomodulatory, anti-carcinogenic, hepatoprotective, cardioprotective, anti-atherogenic and radioprotective etc. in nature. Sea buckthorn is primarily consumed in its natural form although various products has been prepared. The potential of sea buckthorn as nutraceutical is abundant. When it comes to its medicinal aspect it can be used as extracts of pure form for curative as well as preventive measure of medical conditions. Many studies have showed Sea buckthorn as effective game changer to treat cancer as well as cardiovascular disorders and gastrointestinal ulcers. Cosmeceuticals that use sea buckthorn as ingredients has found to be effective on blackheads, dry skin, etc. Also, it is used as medicine in various skin diseases. Along with all the benefits and potentials it is necessary to develop effective products i.e., food, drugs, feed, cosmeceuticals in a market suitable and commercializable way to achieve and justify consumer demand and market trend.
Seaweed is a general nomenclature used species of algae and marine plants breed in water bodies like rivers and oceans. They grow in a wide range of sizes from microscopic to stupendous. Seaweed, or macro algae as it is known scientifically, includes over 10,000 species of the fastest growing plants on earth. Seaweeds come in an amazing variety of beautiful shapes, colors and sizes, and are found in all of the World. They are most abundant in shallow rocky coastal areas, especially where they are exposed at low tide. Seaweed is taxonomically classified under four groups according to the color of photosynthetic pigments namely red algae (rhodophyta), brown algae (phaeophyta), green algae (chlorophyta) and blue green algae (cyanophyta). Seaweeds are one of the most nutritionally and therapeutically valuable foods. Their value to health is largely due to their high mineral content and the therapeutic sulfated polysaccharides. Seaweeds are also a source of all the known vitamins, chlorophyl lignans, polyphenols, antioxidants and chemical diversity including pigments, polysaccharides, organic, and inorganic compounds which are used as animal fodder, food, nutraceuticals, pharmaceuticals, and cosmeceutical. The aim of this review is to accumulate in brief, the therapeutics and medicinal uses of seaweed on the some mentioned ailments.
marine drugs, 2022
: Since ancient times, seaweeds have been employed as source of highly bioactive secondary metabolites that could act as key medicinal components. Furthermore, research into the biological activity of certain seaweed compounds has progressed significantly, with an emphasis on their composition and application for human and animal nutrition. Seaweeds have many uses: they are consumed as fodder, and have been used in medicines, cosmetics, energy, fertilizers, and industrial agar and alginate biosynthesis. The beneficial effects of seaweed are mostly due to the presence of minerals, vitamins, phenols, polysaccharides, and sterols, as well as several other bioactive com‐pounds. These compounds seem to have antioxidant, anti‐inflammatory, anti‐cancer, antimicrobial, and anti‐diabetic activities. Recent advances and limitations for seaweed bioactive as a nutraceutical in terms of bioavailability are explored in order to better comprehend their therapeutic develop‐ ment. To further understand the mechanism of action of seaweed chemicals, more research is needed as is an investigation into their potential usage in pharmaceutical companies and other applications, with the ultimate objective of developing sustainable and healthier products. The objective of this review is to collect information about the role of seaweeds on nutritional, pharmacolog‐ical, industrial, and biochemical applications, as well as their impact on human health
Seaweed Biomaterials
Edible seaweeds are rich in bioactive compounds such as soluble dietary fibers, proteins, peptides, minerals, vitamins, polyunsaturated fatty acids and antioxidants. Previously, seaweeds were only used as gelling and thickening agents in the food or pharmaceutical industries, recent researches have revealed their potential as complementary medicine. The red, brown and green seaweeds have been shown to have therapeutic properties for health and disease management, such as anticancer, antiobesity, antidiabetic, antihypertensive, antihyperlipidemic, antioxidant, anticoagulant, anti-inflammatory, immunomodulatory, antiestrogenic, thyroid stimulating, neuroprotective, antiviral, antifungal, antibacterial and tissue healing properties. In proposed chapter, we discussed various active compounds include sulphated polysaccharides, phlorotannins, carotenoids (e.g. fucoxanthin), minerals, peptides and sulfolipids, with proven benefits against degenerative metabolic diseases. Moreover, therapeutic modes of action of these bioactive components and their reports are summarized in this chapter.
Seaweeds (marine macro algae) are extremely important oceanic resource having unique secondary metabolites. They have the potential for supporting industrial development as being source of many essential substances such as pharmaceuticals, cosmetics, nutritional supplements etc. Seaweeds offer a wide range of therapeutic possibilities was established only some decades ahead. Several pharmacologically important metabolites have been discovered from seaweeds in recent years, the exploitation of seaweeds for therapeutically active molecules is still in its embryonic stage. In order to harness the rich therapeutic potential of seaweeds the present limited use needs to be diversified into several applications. Present review highlights a state of art on the medicinal value of seaweeds and their exploitation scenario on a global scale.
2014
Background: Seabuckthorn (SBT, Hippophae rhamnoides L.) is an important medicinal plant of cold desert areas. Therapeutic significance of various parts of this plant has been mentioned in many traditional medicinal systems, especially Chinese and Tibetan systems. There are many pharmacological reports suggesting therapeutic usefulness of SBT leaf extracts, however, relatively very few toxicity studies are available on these extracts.
Food Science and Technology, 2021
This study aims to evaluate the secondary metabolites, cytotoxicity, antioxidant, antidiabetic, anti-inflammatory, and anticancer activities of four selected seaweeds Padina pavonica, Taonia atomaria, Jania rubens, and Corallina elongata. The maximum value of phenolic content (176.7 ± 6.9 mg gallic acid equivalents/g crude extract) and tannin content (26.5 ± 4.3 mg tannic acid equivalents/g crude extract), was shown in the methanol extract of J. rubens and P. pavonica, respectively. While the ethanol extract of T. atomaria recorded the highest values of total flavonoid content (374.1 ±27.4 mg quercetin equivalents/g crude extract) and total saponins content (30.2 ± 0.7 mg cholesterol equivalents/g crude extract, respectively) compared to other seaweeds. Methanol extract of J. rubens and C. elongata exhibited the greatest content of alkaloids (25.8 ± 4.4 and 22.7 ± 2.6 mg/g d wt.). The methanol extract of P. pavonica established the highest DPPH radical scavenging activity (55.7% ± 0.1) at 50 μg/mL. Among the selected seaweed extracts, the ethanol extract of T. atomaria demonstrated the maximum α-amylase inhibition capacity (66.3% ± 0.0). Methanol extract of J. rubens and P. pavonica species effectively prevented the hypotonicity-induced haemolysis in a concentration-dependent manner compared with the diclofenac potassium as a standard anti-inflammatory drug. In vitro, the reported results also supported the safety and non-toxicity of the four seaweed extracts on WI-38 cell line at lower concentrations. J. rubens and P. pavonica methanol extracts recorded the highest cell growth inhibition of the HeLa Cancer Cell Lines compared to other seaweed extracts and the standard drug Cisplatin.
International journal of basic and clinical pharmacology, 2021
Seaweeds in general are known to contribute to the maintenance of health through their nutritional and medicinal properties and are served in soups and salads, cooked with grains, legumes or miso-soup broth, vegetable pies, stews and even consumed dried. The medicinal properties of seaweeds or vegetables have long been known in many cultures of people particularly those living in the coastal regions who are consuming these from centuries. Traditional Chinese dietotherapy (TCD) makes good use of natural marine nutrients and food to preserve health. Koreans wrap their bodies in seaweeds to get rid of deadly body toxins and Japanese who eat large quantities of seaweeds have very low incidence of cancers. The compounds with diverse biological activities such as antioxidant, antiviral, antifungal, antineoplastic, antimicrobial etc. have been isolated from the flora in the sea. A score of these bio-medicinal compounds are in different stages of clinical trials & analysis and are the focus...
2019
The global economic effect of the five driving chronic diseases-malignancy, diabetes, psychological instability, CVD, and respiratory disease- could reach $47 trillion throughout the following 20 years, as indicated by an examination by the World Economic Forum (WEF). As per the WHO, 80% of the total people principally those of developing countries depend on plant-inferred medicines for social insurance. The indicated efficacies of seaweed inferred phytochemicals are demonstrating incredible potential in obesity, T2DM, metabolic syndrome, CVD, IBD, sexual dysfunction and a few cancers. Hence, WHO, UN-FAO, UNICEF and governments have indicated a developing enthusiasm for these offbeat nourishments with wellbeing advancing impacts. Edible marine macro-algae (seaweed) are of intrigue in view of their incentive in nutrition and medicine. Seaweeds contain a few bioactive substances like polysaccharides, proteins, lipids, polyphenols, and pigments, all of which may have useful well-being ...
International Journal of Clinical Pharmacology & Toxicology, 2019
According to the WHO, 2.3 billion adults are overweight and the prevalence is higher in females of childbearing age than males [1]. In the US, the economic burden is estimated to be about $100 billion annually [2]. Worldwide obesity causes 2.8 million deaths per year and 35.8 million disability-adjusted life-years, some 45% of diabetes, 25% of IHDs and up to 41% of certain cancers [3]. Four major bioactive compounds from seaweeds which have the potential as anti-obesity agents are fucoxanthin, alginates, fucoidans and phlorotannins [4]. Alginates are amongst the seaweed fibers that are well-known for their anti-obesity effects. They have been shown to inhibit pepsin, pancreatic lipase [5], reduced body
Asian Journal of Pharmaceutical and Clinical Research, 2021
Several biologically active secondary metabolites from aquatic plants have been extracted and identified using modern instrumental BioTechniques and used in various ways as flavors, food, additives, coloring agents, nutraceuticals, cosmetics, and also as unique source of pharma industries for the discovery or development of new drugs. From algae to aquatic macrophytes belonging to various categories, aquatic plants produce a variety of compounds such as polyketides, peptides, alkaloids, flavonoids, phenolic compounds, terpenes, steroids, quinones, tannins, coumarins, and essential oils commercially involving in antibiotic, antiviral, antioxidant, antifouling, anti-inflammatory, anticancer, cytotoxic, and antimitotic activities; thus making them a rich source of medicinal compounds. Moreover, they are comprehensively used in human therapy, veterinary, agriculture, scientific research, and in countless areas. Importantly these chemicals are exercised for developing new antimicrobial a...
Food Science and Human Wellness, 2019
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2024
The increasing demand of mankind for a healthier life and increased longevity has led humans to consume functional foods with plenteous sources of biochemical compounds and other nutraceuticals. Among these famous natural resources, seaweeds are considered as one of the most precious natural resources for macronutrients (carbohydrates, proteins, and lipids), micronutrients (vitamins and minerals), and other significant bioactive substances for animal and human health. Green seaweeds are commonly classified as "Chlorophyta" because of their green pigment dominance. Green seaweeds also known as green algae are considered as an important marine biological resource possess a variety of medicinal and biological actions including anti-inflammatory, anti-oxidant, analgesic, immuno-regulatory etc. They are a rich source of nutritional and bioactive components which are responsible for numerous therapeutic activities. Despite of the magnificent advancement in alternative medicines, land plants are more extensively, frequently, and commonly explored for biological and medicinal activities as compared to marine plants. This systematic review is constituted after comprehensively reviewing peer-reviewed publications of renowned and authentic online databases including Elsevier, Scopus, Web of Science, Pubmed, etc. Records of present and potential medicinal, bio-medical and pharmaceutical uses of green seaweeds from 2000 to the present had been reviewed and considered to constitute this review. This review will highlight some common green seaweeds including Bryopsis plumosa, Chaetomorpha antennina, Acrosiphonia orientalis, Ulva fasciata and Ulva prolifera. The basic purpose of this review is to provide updated knowledge and information about marine green seaweeds which will be valuable for the scientists working in the field of pharmacology, pharmacognosy and biomedicine. This review will also help the marine scientists and pharmacologists to explore these seaweeds further to evaluate and discover their true efficacy and therapeutic potential in human beings and in different disease models.
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