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ARTIKEL ALLOPURINOL, ASHARA NABILA P

Abstract

Hyperuricemia is a condition of increased uric acid levels in the blood that can trigger various complications, such as gout and nephropathy. Allopurinol is a pharmacological agent that is widely used to inhibit the xanthine oxidase enzyme, thereby reducing uric acid production. This study aims to evaluate the effectiveness and safety of allopurinol in reducing uric acid levels in hyperuricemia patients. The study was conducted by analyzing the results of previous studies involving hyperuricemia patients who received allopurinol therapy with doses adjusted based on the severity of hyperuricemia and kidney function. The results of the study showed that consistent use of allopurinol can significantly reduce uric acid levels, especially in patients with chronic gout. However, side effects such as hypersensitivity reactions and impaired liver function require close monitoring. Therefore, the use of allopurinol needs to be adjusted to the patient's profile to maximize the benefits of therapy and minimize the risk of side effects.