Assessment of Alterations in Reproductive Hormones due to

Machado et al. investigated dengue among women of reproductive age (15-49 years) in Rio de Janeiro, Brazil [1]. The results showed that of the 546 recruited women who had confirmed dengue, 18.1% were pregnant and 81.9% were not. Of the diagnosed cases, 76.4% had dengue fever (DF), 22.5% had dengue hemorrhagic fever (DHF) and 1.1% had dengue shock syndrome. There was no significant difference in the incidence of dengue between pregnant and nonpregnant women. Pregnant women were at 3.4-times higher risk to have severe dengue infection than their nonpregnant counterparts. The case-fatality rate was 7.4 and 1.5% among pregnant and nonpregnant women, respectively. Investigating the pathogenesis of the susceptibility of pregnant women to severe dengue infection may well be an important point in research and development of the future dengue vaccine. Recently, Machado et al. investigated dengue among pregnant women in Rio de Janeiro [1]. Dengue is the most common mosquito-borne infection and is caused by four distinct viral serotypes (DENV1, 2, 3 and 4). Approximately 3 billion people are at risk of dengue due to living in or traveling through regions infested by Aedes aegypti mosquitoes, which are the main vector for this disease [2]. Urbanization, increased population density, air travel and limited resources for dengue prevention are the factors that led to dengue becoming an exceedingly important public health problem, especially in the tropics. Currently there are no antiviral therapies or licensed vaccines for the prevention or treatment

2016

Dengue fever is an acute febrile disease in the tropical and subtropical areas and today is being acknowledged as one of the world’s major emerging infectious disease.In the last 50 years, incidence has increased 30 folds. An estimated 2.5 billion live in over 100 endemic countries and areas were dengue can be transmitted. Up to 50 million infections occur annually with 500000 cases of dengue hemorrhagic fever and 22000 deaths in children with wide spectrum of clinical features (1). Hence the study was undertaken to study the clinical features in dengue patients. Aims and Objectives: The study is undertaken to study the clinical spectrum of dengue fever and to co relate various haematological and biochemical parameters with severity of dengue. Materials and methods: A prospective observational hospital based study carried out in Mahatma Gandhi Memorial Hospital, Kamothe, Mumbai over a period of two years in 100 IPD and OPD patients with fever who were investigated and found to be ei...

International Journal of Medical Research and Review

Aim and objective: The objective of this study was to correlate laboratory tests during the evolution of dengue fever, comparing frequencies between the different clinical forms in order to use test results to predict the severity of the disease. Methods: This is an observational, descriptive and retrospective study of 50 patients with clinical and serological diagnoses of dengue fever. The tests analyzed were blood count, platelet count, and serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations. Results: Thrombocytopenia and elevated transaminases were observed in patients with classic dengue fever. The main laboratory abnormalities found in dengue hemorrhagic fever were thrombocytopenia, hemoconcentration and elevated transaminases, similar to severe dengue with the exception of hemoconcentration. Most laboratory abnormalities started on the 3rd day but were more evident on the 5th day with restoration of values by the 11 th day; this was more prominent in under 15-year-olds and with the more severe clinical forms. Conclusion: These results are relevant in assessing the disease because they can be used as markers for more severe forms and can help by enabling the adaptation of the therapeutic conduct to the needs of individual patients.

The Southeast Asian journal of tropical medicine and public health

Journal of Evolution of Medical and Dental Sciences

BACKGROUND Dengue fever is a vector-borne disease common in the tropics. It is known to have an adverse effect on pregnant women with unfavourable foetal outcomes. However, only a few studies are addressing this problem. Many of the studies had confounding factors such as the simultaneous occurrence of other vector-borne diseases and maternal health conditions. Therefore, the actual impact of dengue fever on pregnancy and pregnancy outcome is not clear. We wanted to study maternal and foetal outcomes in dengue positive pregnant females. METHODS This is a retrospective study done over 6 months in a tertiary care institute. Data regarding demography, obstetric history, biochemical parameters / blood investigation and pregnancy outcomes were collected and analysed. RESULTS Most of the dengue positive women presented with fever and thrombocytopenia in 44 % of cases. Obstetric complications such as preterm labour, abruption and postpartum haemorrhage (PPH) were common. Caesarean section ...

Asian Journal of Pharmaceutical and Clinical Research, 2021

Dengue fever virus (DENV) is said to be a single-stranded, positive-sense RNA virus that belongs to the family Flaviviridae and the genus is Flavivirus. The disease can be transmitted through infected blood products and also through organ donation. Vertical transmission (from mother to child) at the time of pregnancy or during birth has been reported. Other unusual reports showed man-to-man modes of transmission. Hemorrhagic fever is specified by hemorrhage, thrombocytopenia, leakage of blood plasma, or dengue shock syndrome. Dengue is basically transmitted by various species of mosquito among the genus Aedes, the most uniquely identified one is Aedes aegypti. There are four different but very closely related serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) of the virus that causes Dengue. Lifelong immunity against the particular serotype that has caused the infection is believed to have been imparted upon recovery. However, cross-immunity to the other serotypes is either partial or t...

Esculapio, 2023

soon time of year. According to the estimation of WHO, this world's two third population is at the risk of the dengue virus infec-1 tion, particularly the tropical and subtropical countries . While dengue is endemic in many countries, majority cases are reported from Southeast Asia and the western 3 Pacific regions. In South East Asian region, India is one of the seven countries that has reported high incidence of dengue outbreaks threatening the health care system 4 badly . In 1940's, India reported firs confirmed case of dengue fever & after that more states started reporting 5,6 this. In Bangladesh its true magnitude was essentially 4,7 unknown until it manifested heavily in 2000. In Pakistan, first outbreak of DHF was confirmed in Karachi that happened in 1994 with total 145 cases and 8 only one case of fatality was reported. Punjab has now encountered this infection for more than a decade and 1,2 is passing on to hyperendemicity. Dengue infection has demonstrated great variations in presentation from mild illness to complicated dengue hemorrhagic fever (DHF) and dengue shock syndrome 7,9

Clinical Medicine, 2022

Dengue is an arboviral infection that is hyperendemic in tropical and subtropical climates. Clinical manifestations of dengue can range from asymptomatic infection to severe infection with multi-organ failure. Dengue haemorrhagic fever (DHF) is a subcategory in dengue infection with a hallmark of plasma leak (ie critical phase). The plasma leak in DHF is selective (pleuroperitoneal spaces), transient and dynamic, and needs careful monitoring and meticulous fluid resuscitation. In addition, dengue fever may present with extended and unusual manifestations affecting any organ, including the heart, liver, kidney and brain. Studies on vaccine development and vector control are ongoing to prevent this infection of global importance. In this article, the clinicopathological features and management aspects of dengue are discussed.

Journal of Pharmaceutical Research International, 2021

Mortality rate caused by dengue in tropical urban life by a vector mosquito possess severe effects including children. This is an observational study carried out in a tertiary care hospital in Navi Mumbai, from June 2006 to August 2008 area which is endemic for vector borne diseases. The clinical signs, symptoms, hematological parameters and serological correlation in 100 serologically positive for IgM and IgG children confirmed by Mac ELISA were studied. Chi-square test of significance was applied between the selected laboratory and clinical parameters. The outcomes of the study were provided with a high incidence of infection was seen in the age group of 6-10 years (50%), with a male (63%) predominance affection. Fever (100%), along with Vomiting (89%), myalgia (45%) and abdominal pain (27%) are the most common symptoms associated with dengue. Other symptoms found in childrens affected by dengue shows hemorrhagic manifestation (25%), hepatomegaly (78%), as cites and effusion (50%)...

Research Journal of Pharmacy and Technology, 2013

Dengue fever is a common tropical infection. This acute febrile illness can be a deadly infection in cases of severe manifestation, causing dengue hemorrhagic shock. In this brief article, I will summarize and discuss the diagnosis and treatment of this disease. In 1998 this mosquito-borne disease is the most important tropical infectious disease after malaria, with an estimated 100 million cases of dengue fever, 500,000 cases of dengue hemorrhagic fever, and 25,000 deaths annually. The reasons for this resurgence and emergence of dengue hemorrhagic fever in the waning years of the 20th century are complex and not fully understood, but demographic, societal, and public health infrastructure changes in the past 30 years have contributed greatly. This paper reviews the changing epidemiology of dengue and dengue hemorrhagic fever by geographic region, the natural history and transmission cycles, clinical diagnosis of both dengue fever and dengue hemorrhagic fever, serologic and virolog...