Can Sars COV2 Damage Placenta?

EXPERIMENTAL & CLINICAL MEDICINE GEORGIA

The purpose of the study was to review the spread of some endocrine disorders in Georgia under the conditions of the Covid-19 pandemic. The distribution of some diseases of the endocrine system between 2015 and 2021 was analyzed, such as diabetes mellitus -type I and II, as well as thyroid gland diseases -iodine-deficiency hypothyroidism and other forms of hypothyroidism, thyroiditis, thyrotoxicosis. It was determined that during the pandemic, the morbidity rate of these diseases was significantly (almost 2 times) lower than the values recorded before the pandemic. It should be noted that, most likely, these indicators cannot reflect the true number of patients, which is related to the isolation of the population and the disruption of registration in the conditions of the Covid-19 pandemic. Disorders of the endocrine system, nutrition and metabolism during the current pandemic have not yet been adequately studied. The association between endocrine, nutritional and metabolic disorders and covid-19 is mostly tentative and based on recent small-scale studies. In order to obtain reliable conclusions about the existence of a correlation relationship, it is necessary to continue research on the mentioned issue, in particular, to study the detection and frequency of cases of thyroid gland and pancreas dysfunction in groups of people infected with and vaccinated against Covid-19.

TSMU COLLECTION OF SCIENTIFIC WORKS, 2021

Diabetes mellitus is one of the most common chronic disease. In a number of developing and industrialized countries, diabetes mellitus has become an epidemic and is one of the leading causes of death. The rapid increase of cases of type 2 diabetes mellitus (T2DM) in the past decades has made it a widespread metabolic disorder. In recent years, an increasing understanding of how our microflora is linked to obesity-related T2DM has provided a new potential target for reducing the risk of T2DM. The aim of our project is to expand our view on the key roles of microflora during the onset and development of T2DM as well as its complications. Our aim was to study 2 groups of people with T2DM and Prediabetes in order to reveal any gastro-intestinal problems. According to questionnaires, it appeared that patients with diabetes type 2 had 3 or more gastrointestinal disorders, 72 % had bloating, 16% constipation and 12% diarrhea. Patients with prediabetes had 3 and more intestinal disorders: 5...

2021

The aim of our study was to determine the effectiveness of treatment in cases of cerebral palsy using early and regular physical therapy. For the first time, we studied each movement of children with cerebral palsy, because early and continuous physical therapy helps to reduce the degree of abnormal movement of people with disabilities. The data obtained from the study allow us to predict the targeted use of appropriate exercises for different forms of cerebral palsy.

GEORGIAN SCIENTISTS

Breast cancer is a heterogeneous disease that can be divided into different molecular subtypes, each with different clinical and pathological characteristics. HER2-positive breast cancer is a subtype characterized by overexpression of the HER2 protein, which is associated with aggressive tumor behavior. The process of epithelial-mesenchymal transformation (EMT) is believed to play a critical role in tumor invasion, metastasis, and resistance to therapy in HER2-positive breast cancer. Tumorinfiltrating lymphocytes (TIL) are an important component of the host's immune response against Georgian Scientists/ქართველი მეცნიერები ტ. 5 N 2, 2023 149 cancer, and their presence and composition have been shown to correlate with clinical outcome in various types of cancer, including breast cancer. Our study aims to reveal the phenotypic heterogeneity of EMT in different tumor sites, including the primary tumor focus, tumor "Buds" and metastatic lymph nodes by molecular typing of HER2enriched breast cancer. The expression of EMT markers, including E-cadherin, Beta-catenin and vimentin, was measured and significant differences in expression were detected. The presence of EMT in the main tumor focus and tumor "Buds'' was associated with a worse clinical outcome. Furthermore, the presence and composition of TILs varied between tumor sites and correlated with the expression of EMT markers. Based on the findings, it can be assumed that EMT is a heterogeneous process and that the presence of EMT in different tumor sites may have different clinical implications for HER2-positive breast cancer. Identification of biomarkers associated with EMT and TILs may facilitate the development of targeted therapies and improve personalized treatment for patients with HER2-positive breast cancer.

2021

The aim of our study was to determine the effectiveness of treatment in cases of cerebral palsy using early and regular physical therapy. In the beginning, we studied each movement of children with cerebral palsy, because early and continuous physical therapy helps to reduce the degree of abnormal movement of people with disabilities. Based on the results of this research we can predict the targeted use of appropriate exercises for different forms of cerebral palsy.

EXPERIMENTAL & CLINICAL MEDICINE GEORGIA

Anxiety disorders have become the number one mental health issue in developed countries. The number of people living with anxiety and depressive disorders rose significantly because of the COVID-19 pandemic. Although generally considered as safe and effective, the currently available anxiolytic therapy is responsible for numerous side effects and addiction. Therefore, there is an imperious demand for discovering more efficient and cheaper new groups of pharmaceuticals ("green anxiolytic"). There is a big number of research, studying plants containing coumarins as active compounds, especially those belonging to the Apiaceae family. Laboratory studies already suggest the anti-anxiety activity of various extracts of Angelica Archangelica. Therefore, the aim of our study was to obtain the methanolic extract of Angelica adzharica and evaluate the potential anxiolytic effect based on the zebrafish larvae model. According to our knowledge, this is the first report studying the anxiolytic effect of Angelica adzharica extract based on the zebrafish larvae.

Ek'sperimentuli da klinikuri medic'ina, 2022

Herein we are presenting unusual case of severe neutropenia and JIA in a child. To our understanding, in this particular case, maternal Covid-19 caused an unusual presentation of neutropenia and JIA, with very high ANF. The role of neutrophils in pediatric rheumatology is an understudied field but is receiving increasing attention. Although clearly implicated in JIA, the specific contribution of neutrophils to pathogenesis and the use of neutrophil activity as biomarkers require further study.

EXPERIMENTAL & CLINICAL MEDICINE GEORGIA

In the region of Bolnisi-Dmanisi, mineral extraction is carried out, where the certificate (ISO) is not maintained and the environment is polluted. Quantitative study of heavy metals, in particular cadmium, in this area shows that an increase in the concentration of cadmium is observed along the coastline of the Mashavera river, which poses a threat to human health. Aim of the study: monitoring of the content of cadmium in the water of the river Mashavera in the region of Bolnisi-Dmanisi. Monitoring in 2021-2022 revealed that the concentration of the heavy metal cadmium in the Mashavera river is increased, especially in the summer period in the settlements located near the quarry. The fact is very remarkable and requires the adoption of appropriate measures, as the population uses this water for irrigation, and the cadmium contained in the water accumulates in the vegetables, the population uses vegetables for food. The accumulation of cadmium in the human body is a risk factor for the development of acute or chronic diseases.

GEORGIAN SCIENTISTS

MOAMBE, 2023

The article discusses issues of crisis communication, a still developing direction among social sciences. Its thorough study began in the 80s of the 20th century and, therefore, it is accompanied by certain difficulties, including different opinions about the definition, the lack of empirical studies and the undefined possibilities of social media, because of which a crisis can be planned and instigated in the virtual space by a single social network user. It should be noted that crisis communication, as a discipline, is mostly based on the case study method, and the existing theories of crisis communication are being improved along with technological progress. Virtual space itself creates new crises and dictates new, unusual standards of crisis communications, with which there is virtually no precedent for dealing with. However, social media has a great opportunity to influence not only the course of crisis communication, but also the future perspective of companies and the formation of public opinion.