Caesarean Section and Placental Transfer of Alcuronium
Paul Ho1981, Anaesthesia and Intensive Care
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Abstract
The placental transfer of alcuronium was studied in twelve patients undergoing elective or emergency caesarean section. Umbilical cord vein and maternal plasma was analysed for alcuronium at dose-delivery time intervals ranging from 5 to 10.5 minutes. The mean umbilical vein concentration of the relaxant was 0.41 ± 0.18 (SD) Jig/ml, and the mean foetal/maternal concentration ratio was 0.26 ± 0.11. A positive correlation between foetal and maternal concentrations of alcuronium was demonstrated. Although alcuronium appears to cross the placenta rapidly and in reasonably high concentration, no apparent adverse effects on the neonates was evident as judged by measurement of Apgar scores.
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Transport kinetics of chromium in perfused human placental lobule in late gestation: in vitro study
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Residual curarization in the neonate after Caesarean section
Canadian Journal of Anaesthesia, 1991
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Drug and chemical toxicology, 2018
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European Journal of Clinical Nutrition, 1999
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Maternal second trimester blood levels of selected heavy metals in pregnancies complicated with neural tube defects
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2018
Neural tube defects (NTDs) are the most common malformations of the central nervous system (CNS). There is continuing research for the identification of risk factors and interventions for prevention of NTDs. The aim of this study was to investigate the maternal second trimester blood levels of selected heavy metals namely, arsenic (As), cadmium (Cd), mercury (Hg), manganese (Mn), nickel (Ni), and lead (Pb) and their possible relation with the occurrence of NTDs. Twenty-one healthy second trimester pregnant women with fetuses affected with NTD (cases) were matched with 21 healthy pregnant women with unaffected fetuses (controls) with respect to age, body mass index (BMI), and gestational age. Maternal blood levels of heavy metals were measured after an overnight fasting period. No significant differences were observed in terms of maternal blood levels of As, Cd, Hg, and Ni between NTD-affected and unaffected pregnancies. The blood Pb and Mn levels were found to be higher in pregnant ...
Methodological Validation for the Determination of Ca, Cr, Mg and Mn in Umbilical Cord and Maternal Blood (City of Vale do Paraíba, São Paulo, Brazil)
International Journal of Food Science and Nutrition Engineering, 2012
This investigation focused on the validation o f the methodology used in determining the presence of specific elements in human blood. Concentrations of macro-and micronutrients in umbilical b lood (UCB) samples fro m 37 lactating volunteers who gave birth in the city of Taubaté , State of Sã o Paulo, Brazil. The determinations of Ca and Mg were carried out in a flame ato mic absorption spectrometer (FAAS) and those of Cr and Mn in a graphite furnace ato mic absorption spectrometer (GFAAS). A procedure for preparing samples was optimized and evaluated. Standard addition methods and determinations by ICP OES were used to validate the analytical procedures. An acetylene/air mixture was optimized at 2.0/17.0 L min-1 (Ca and Mg). Pyrolysis and atomizat ion temperatures for Cr were at 1400°C and 2100°C, respectively, for Mn at 1300°C and 1700°C, respectively. The most efficient chemical modifier was a solution containing 5 g of Pd + 3 g of Mg(NO3)2. Characteristic masses for Cr and Mn were 2.6 and 2.7 pg, respectively. The methods presented high analytical efficiency in the determination of Ca, Cr, Mg and Mn (recovery fro m 98.68% to 108.22 %). M inimal data variations in repeatability and reproducibility indicated significient precision and accuracy for the proposed methodology. The placenta did not block transport of elements fro m mother to fetus. The contents of the elements analyzed in the UCB were co mpared to those detected in maternal blood (M B). Most of the children exh ibited normal weight (fro m 2.5 to 3.0 kg) as per the Brazilian Min istry of Health standards. Such results indicate that the levels of concentrations of the elements in the UCB did not affect the weights of the neonates. activity is also reduced . These characteristics in neonates facilitate a h igher potential fo r the absorption of elements in contrast with adults. This greater absorption capacity is also applicable for various toxic elements .
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The Effect of Heavy Metals and Trace Elements in the Meconium on Preterm Delivery of Unknown Etiology
… Klinikleri Journal of …, 2012
Objective: Prematurity is an important etiologic factor for perinatal mortality and morbidity. In our country, preterm births and complications of prematurity account for 26% of perinatal mortality. There are many maternal, fetal or placental, genetic and environmental etiologic ...
Examination of Trace Metals and Their Potential Transplacental Transfer in Pregnancy
International Journal of Molecular Sciences
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Metallomics, 2010
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Interactions between 14 Elements in the Human Placenta, Fetal Membrane and Umbilical Cord
International Journal of Environmental Research and Public Health
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Pancuronium and the Neonate
BJA: British Journal of Anaesthesia, 1975
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Heavy metal ion concentration in the amniotic fluid of preterm and term pregnancies from two cities with different industrial output
Experimental and Therapeutic Medicine, 2021
The growth and development of the fetus is a complex phenomenon that can be influenced by several variables. High quantities of heavy metal ions in the amniotic fluid have been linked to poor health, especially in industrial, polluted and poor areas. The aim of the present study was to assess the differences in the concentration of these ions between preterm (weeks 15-37) and term pregnancies (starting at week 37). Another objective was to compare pregnancies from two cities with different industry levels. Two sample lots from two Romanian cities were analyzed. A total of 100 patients from Timisoara were compared with 60 from Petrosani, a heavy industry city in Romania. Demographic data were collected, and amniocentesis was performed on all women. Lead (Pb), copper (Cu), nickel (Ni), cadmium (Cd), arsenic (As), iron (Fe) and zinc (Zn) concentrations were assessed. Descriptive and analytical statistics were performed using the Mann-Whitney U test for non-parametric data and the Fisher's exact test for categorical data. In addition, categorical data was represented graphically. In the Timisoara cohort, the differences in heavy metal concentrations between preterm and term pregnancies were not statistically significant. In the Petrosani cohort, however, the concentrations of Zn (P=0.02606) and Cd (P=0.01512) were higher in preterm than in term pregnancies. When comparing the two cohorts as a whole, the concentration of Pb (P=0.04513), Cd (P=0.00002), As (P=0.03027) and Zn (P<0.00001) were higher in the patients from Petrosani than in those from Timisoara. Only Cu concentrations were higher in the Timisoara cohort (P<0.00001). The concentrations of Ni (P=0.78150) and Fe (P=0.44540) did not differ statistically. Thus, amniocentesis is an important diagnostic and exploratory tool in determining differences in the concentrations of elements such as heavy metal ions. Research over a longer period of time should be carried out to examine the relation between heavy metal ions concentration and possible postnatal health outcomes.
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