Tissue engineering: A new era in dentistry

Dental Materials, 2012

d e n t a l m a t e r i a l s 2 8 ( 2 0 1 2 ) 341-348 Scaffolds Molecular biology Restorative dentistry a b s t r a c t Tissue engineering is an interdisciplinary field that combines the principles of engineering, material and biological sciences toward the development of therapeutic strategies and biological substitutes that restore, maintain, replace or improve biological functions. The association of biomaterials, stem cells, growth and differentiation factors has yielded the development of new treatment opportunities in most of the biomedical areas, including

The science of tissue engineering aims at the repair of damaged tissues as well as creates replacement of the lost ones. This is becoming a major component of the regenerative medicine by combining the principles of transplantation, materials science and bioengineering to restore a diseased or a damaged tissue to normal function. The earliest attempts at tissue replacement thousands of years back involved teeth and even in modern times, dentistry has continued to place considerable emphasis on the study and use of biocompatible materials. For most of the general dental practitioners restoration of lost tooth tissue, whether from disease or trauma, represents a significant proportion of their daily routine. Considering the current prevalence of the dental diseases, it can be said that the challenge and resource burden of restoring lost tooth tissue will be with us for many years to come. Tissue engineering will have a considerable effect on dental practice during the next coming years. The greatest effects will likely be related to the repair and replacement of mineralized tissues, the promotion of oral wound healing, correction of craniofacial abnormalities, integration of biocompatible prosthetic implant materials with the oral tissues, the regeneration of dental hard and soft tissues and the use of gene transfer adjunctively. The purpose of this brief review is to provide the general dental practitioner a background of tissue engineering, its accomplishments in dentistry and its future promises to the profession in the form of regenerative dentistry.

Clinics in Plastic Surgery, 2003

International Journal of Medical and Dental Sciences, 2015

Tissue engineering is a novel and exciting field that aims to recreate functional, healthy tissues and organs in order to replace diseased, dying, or dead tissues. The association of biomaterials, stem cells, growth and differentiation factors has yielded the development of new treatment opportunities in the field of dentistry. The objective of using tissue engineering as therapeutic application has been to harness its ability to exploit selected and primed cells together with an appropriate mix of regulatory factors, to allow growth and specialization of cells and matrix. Tissue engineering in periodontology applies the principles of engineering and life sciences toward the development of biological techniques that can restore lost alveolar bone, periodontal ligament, and root cementum. This review article focuses on the basics about tissue engineering, its principles and strategies and how these principles can be applied in periodontics to provide us with successful results.

Dental update, 2009

A new direction in the field of vital pulp therapy is given by the introduction of tissue engineering as an emerging science. It aims to regenerate a functional tooth-tissue structure by the interplay of three basic key elements: stem cells, morphogens and scaffolds. It is a multidisciplinary approach that combines the principles of biology, medicine, and engineering to repair and/or regenerate a damaged tissue and/or organ. This two part article reviews and discusses the basic concept and strategies so far studied and researched for the engineering of basic dental tissues, to restore a functional tooth anatomy. This first part focuses on a detailed description of key elements used in tissue engineering and their applied clinical applications in dentistry. The second part will deal with the strategies that are being used and/or developed to regenerate the tooth tissues with the help of this scientific principle. The field of tissue engineering has recently shown promising results an...

International Journal of Medical Research and Review, 2019

Tissue engineering can be defined as the "reconstitution of tissue and organs, in vitro for use as model systems in basic and applied research, or for use as grafts to replace damaged or diseased body parts or body functions". Biomaterials have been used as replacement tissues and grafts have been used to reconstruct defects in craniofacial region till Uristmade the first attempt of producing exogenous bone with the help of bone morphogenetic proteins. The success of tissue engineering over the field of all transplantation is that conceptually a three-dimensional functional tissue is designed. This field has become a boon to the Cranio Maxillofacial surgeons and has provided them with a supplement to existing treatment for reconstruction of Oral & Craniofacial region. The purpose of this article is to present an overview of the various uses of tissue engineering in the field of Oral and Maxillofacial Surgery.

Tissue engineering is a multidisciplinary science. The progress of tissue engineering for dental tissues is promising and various dental soft and hard tissues have been regenerated successfully in vitro using stem cells. Prior to their applications practically, there are a number of challenges and unanswered questions that need to be resolved for further progress. It is expected that in next two to three decades, the field of dentistry will be changed significantly by the availability of innovative tissue engineered products in dental office. The objective of this review paper is to highlight the progress of tissue engineering for various dental hard and soft tissues such as enamel, dentin, alveolar bone, periodontium, oral mucosa, and salivary glands. In addition, the challenges in the progress of tissue engineering and future expectations have been discussed.

Tissue engineering is the science of design and manufacture of new tissues to replace impaired or damaged ones. The key ingredients for tissue engineering are stem cells, the morphogens, or growth factors that regulate their differentiation, and a scaffold of extracellular matrix that constitutes the microenvironment for their growth. Recently, there has been an increasing interest in applying the concept of tissue engineering to endodontics.

Tissue engineering is the science of design and manufacture of new tissues to replace impaired or damaged ones. The key ingredients for tissue engineering are stem cells, growth factors that regulate their differentiation, and a scaffold of extracellular matrix that constitutes the microenvironment for their growth. This article provides an extensive review of literature on the concept of tissue engineering and its application in endodontics.

2016

Copyright © 2014 Maurizio Bossu ̀ et al.This is an open access article distributed under the Creative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In dental practice there is an increasing need for predictable therapeutic protocols able to regenerate tissues that, due to inflammatory or traumatic events, may suffer from loss of their function. One of the topics arising major interest in the research applied to regenerative medicine is represented by tissue engineering and, in particular, by stem cells. The study of stem cells in dentistry over the years has shown an exponential increase in literature. Adult mesenchymal stem cells have recently been isolated and characterized from tooth-related tissues and they might represent, in the near future, a new gold standard in the regeneration of all oral tissues. The aim of our review is to provide an overview on the topic reporting t...