Histomorphological Spectrum of Breast Lesions
Jayaprakash Shetty2016, Journal of Evolution of Medical and Dental Sciences
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Abstract
BACKGROUND Cancer of the breast is the second most common cause of cancer in women. Benign or malignant lesions presenting as mass in the breast causes anxiety to the patients and the family members. AIMS AND OBJECTIVES OF THE STUDY 1. To classify different types of lesions of breast, both benign and malignant. 2. Histomorphological study of various types of benign and malignant breast lesions. 3. To study spectrum of lesions associated with benign and malignant breast diseases. SETTING AND DESIGN All the breast biopsies, lumpectomies, and mastectomy specimens presenting to Department of Pathology of our institution between June 2012 to June 2014. MATERIALS AND METHODS A sample size of 100 cases are included in this study. Clinical details are taken from records. The specimens of breast sent to the Department of Pathology are processed by routine histopathological techniques. Histopathological features are studied on haematoxylin and eosin-stained sections. STATISTICAL ANALYSIS Statistically, the test of proportion is used to obtain the frequency of all lesions. Chi-square test, which is used to find the association between the spectrum of lesions showed a p value of 0.0438 and hence the study was considered significant. RESULTS In our study, out of 100 cases, malignant breast lesions constituted the majority of the lesions comprising of 49 cases (49%), followed by benign lesions comprising 46 cases (46%) and the inflammatory lesions comprising 5 cases (5%). Among benign lesions, fibrocystic disease was the predominant lesion comprising of 39 cases (41%), followed by fibroadenoma comprising 26 cases (28%), which is followed by 13 cases (14%) of fibrocystic disease with columnar cell change and 8 cases (9%) of sclerosing adenosis. Among malignant lesions, invasive ductal carcinoma (NST) type was the most common lesion comprising 31 cases (61%) followed by 11 cases (21%) of invasive lobular carcinoma. Invasive papillary carcinoma and medullary carcinoma comprising of 3 cases (6%) each and 1 case (2%) of metaplastic carcinoma. CONCLUSION In the present study, we conclude that the benign breast lesions associated with intermediate and high risk epithelial proliferative lesions, which forms the matter of concern since most of them occurring commonly in young females who are in the reproductive age group. Hence, diagnosing these lesions in small breast biopsies, lumpectomies, and excised specimens is of utmost importance and in this regard these must be carefully evaluated.
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Indian journal of applied basic medical sciences, 2018
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IP innovative publication pvt. ltd, 2019
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Journal of Current and Advance Medical Research
Background: Various types of female breast cancer associated with rapidly increasing age incidence. Objective: The purpose of the present study was to find out the frequency of different types of malignant neoplasm of breast in different age and sex.Methodology: This cross-sectional study was carried out at the Department of Pathology, Chittagong Medical College, Chittagong, Bangladesh from May 2005 to June 2006. Patients presented with breast lump of different age and sex were subjected to this study. Details gross examination was done followed by H & E staining for histopathological study.Result: A total number of 48 samples were selected after fulfilling the inclusion and exclusion criteria. This present study conducted in 27 specimens out of 48 breast lump. Among these benign and malignant were 21 and 27, respectively. Majority of the malignancy found in age group 41-50 years. Histopathologically Invasive ductal carcinoma was common 81.5%.There was significant association betwee...
Histopathological Audit of breast tissue specimen in a medical college hospital of Bangladesh.
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