Regenerative endodontics: An overview

Journal of biomedical materials research. Part B, Applied biomaterials, 2015

Trauma to the dental pulp, physical or microbiologic, can lead to inflammation of the pulp followed by necrosis. The current treatment modality for such cases is non-surgical root canal treatment. The damaged tissue is extirpated and the root canal system prepared. It is then obturated with an inert material such a gutta percha. In spite of advances in techniques and materials, 10%-15% of the cases may end in failure of treatment. Regenerative endodontics combines principles of endodontics, cell biology, and tissue engineering to provide an ideal treatment for inflamed and necrotic pulp. It utilizes mesenchymal stem cells, growth factors, and organ tissue culture to provide treatment. Potential treatment modalities include induction of blood clot for pulp revascularization, scaffold aided regeneration, and pulp implantation. Although in its infancy, successful treatment of damaged pulp tissue has been performed using principles of regenerative endodontics. This field is dynamic and ...

Pulpal regeneration after tooth injury is not easy to accomplish, because of the infected pulp requires tooth extraction or root canal therapy. Current treatment modalities offer high levels of success for many conditions; an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue to revitalize teeth. This review describes the possible techniques that will allow regenerative endodontics to become a reality. These potential approaches include root canal revascularization, postnatal stem cell therapy, pulp implant, scaffolding implant, three dimensional cell printing, injectable scaffolds and gene therapy.

Mansoura Journal of Dentistry, 2021

ABSTRACT Tisue enginering is mainly used to replace the impaired or damaged tisues with new tisues. The key cels involved for tisue enginering are stem cels, the morphogens or growth factors. They wil rapidly multiply and diferentiates and forms tisues. This new technique is now most commonly used in endodontics. The aim of this study was to review about he dental pulp stem cels, which are most common growth factors, and the scafolds used to control their diferentiation. To study the clinical technique for the management of immature non-vital teth based on this novel concept. KEYWORDS: Dental pulp stem cels, morphogens, scafolds, regenerative endodontics, pulp revascularization.

IP Indian Journal of Conservative and Endodontics, 2021

Till last few decades, a necrosed tooth with immature apex was an indication for apexogenesis. With advances in dentistry such as improved irrigation protocols, better visibility to the operating site and increased skills of endodontists, regenerative endodontic procedures have come into the limelight. The alongside research in tissue engineering also have been beneficial for researchers and endodontists to open new horizons in regenerative endodontics. This review paper involves the triad of tissue engineering, concepts of regenerative endodontics applied in past, current protocols according to American Association of Endodontists and future concepts of tooth tissue regenerations which are being researched.

2016

When maintenance of tooth in a vital condition is no longer possible, the traditional treatment philosophy advocates endodontic treatment to retain it in a functional state. A paradigm shift of this thinking occurred with revascularization/regenerative procedures. Dental pulp is a specialized tissue organized in an order spatial arrangement and regenerating it is somewhat exigent. With advancements in molecular science and tissue engineering, the approach is becoming being refined with higher success rates. This review article will detail some of the methods of regeneration and the challenges to achieve success in these procedures.

Journal of Dental Health and Oral Research, 2024

Regenerative endodontics is an innovative field within dentistry that aims to restore damaged dental pulp using stem cells, tissue engineering techniques and biocompatible materials. This article provides an overview of the current trends in regenerative endodontics, highlighting recent research findings. Stem cells obtained from different sources like dental pulp, bone marrow and adipose tissue possess the ability to differentiate into cells similar to dental pulp and facilitate the regeneration of tissues. The use of biocompatible substances, such as Mineral Trioxide Aggregate (MTA) biodentine, offers an ideal setting for tissue growth and healing. Dental scaffolds, made from biodegradable materials, support the development of new blood vessels, nerve fibers and dental pulp-like tissues. Growth factors, like PDGF and TGF-β, are incredibly important in stimulating cell growth and specialization. Researchers and clinical trials are currently working on improving regenerative endodontic procedures, with promising results seen in terms of pulp regeneration and root development. By embracing these trends, dental professionals can offer innovative solutions for restoring damaged dental pulp and preserving natural teeth. The present article, is an overview of regenerative endodontics, exploring the current trends that are shaping the future of this field.

International Dental & Medical Journal of Advanced Research - VOLUME 2015

Regenerative medicine, aims to restore or establish the normal function of lost, diseased, damaged or aging cells, tissues and organs using a range of approaches; including cellbased and gene-based therapies, tissue engineering, and biomedical engineering. The future scope of regenerative endodontics may be increased to include the replacement of periapical tissues, periodontal ligaments, gingiva, and even tooth in-toto. The aim of this article is to review the prospects of endodontic regeneration.Future clinical research would likely focus on translating basic research findings into improved regenerative procedures, such as formation of cementum-like material on the dentinal walls that might lead to studies evaluating benefits of revascularization procedures for overall tooth resistance to fracture. Controlled differentiation into odontoblasts is an important area of research and amenable to tissue engineering concepts. The development of the delivery systems might permit structural reinforcement of the cervical area that might provide clinical opportunities to regenerate lost tooth structure, thereby permitting natural teeth to be retained. Clinical significance: Expanding the scope of regenerative medicine, researchers have also developed and applied regenerative procedures in oral soft and hard tissues.

Transfusion Medicine and Hemotherapy, 2016