Bone involvement in classic Kaposi's sarcoma

Journal of Solid Tumors, 2014

Kaposi sarcoma (KS) is an angio-proliferative disorder and classified in terms of four clearly differentiated variants. Classic variant is an uncommon disease that it has an overwhelming male predominance and majority of cases patients are positive for HIV infections. We present HIV-negative female patient presenting multiple nodules on palmar and dorsal aspect of right wrist. Considering the male predominance of classic KS and positivity of HIV infections in majority of KS cases the patient presented to contribute to the literature.

Acta dermatovenerologica Croatica : ADC, 2005

A 60-year-old male from the Mediterranean area presented with edematous right leg and livid nodules and macules on the skin of upper and lower extremities. Biopsy specimen obtained from the right upper leg showed a pathohistologic finding indicative of Kaposi's sarcoma. Polymerase chain reaction testing revealed HHV-8 in the skin lesion. Serology for HIV was negative. Additional examinations did not reveal dissemination of the disease. Negative HIV serology, normal laboratory findings and absence of immunosuppressant therapy in the patient's history confirmed the diagnosis of the classic form of Kaposi's sarcoma.

Journal Africain du Cancer / African Journal of Cancer, 2014

Kaposi sarcoma is a malignant vascular tumour of multifocal origin from undifferentiated vasoformative spindle cell. It presents frequently as cutaneous lesions, and musculoskeletal involvement is rare. Presented is a 52-year-old male farmer with inability to walk and pain of two months duration with cutaneous lesion noticed 3 years prior to presentation. Clinical, radiological and histopathological evaluation revealed cutaneous Kaposi sarcoma with a rare complication of pathological fracture of the left tibia and fibula with dystrophic calcification of the adjoining soft tissue. He had cytotoxic chemotherapy with poor outcome in cutaneous and skeletal lesions. Kaposi sarcoma if neglected presents with significant morbidity. Health promotion on early presentation and diagnosis are recommended for improved outcome. Keywords Endemic Kaposi sarcoma • Pathological fracture Résumé Le sarcome de Kaposi désigne une tumeur vasculaire maligne d'origine multiple située sur une cellule fusiforme vasoformative indifférenciée. Il se présente fréquemment sous forme de lésions cutanées, et les répercussions musculosquelettiques sont rares. Un fermier de 52 ans se trouvait dans l'incapacité de marcher et ressentait des douleurs depuis deux mois ; des lésions cutanées étaient apparues trois ans plus tôt. Les analyses cliniques, radiologiques et histopathologiques ont révélé un sarcome cutané de Kaposi associé à une rare complication d'une fracture pathologique du tibia et du péroné gauches présentant une calcifi-cation dystrophique des tissus mous adjacents. La chimiothérapie cytotoxique administrée n'a eu que de faibles résultats sur les lésions cutanées et squelettiques. Le sarcome de Kaposi, lorsqu'il est négligé, présente un taux de morbidité élevé. Il est recommandé de procéder à une promotion de la santé lors d'une présentation et d'un diagnostic précoces afin d'améliorer le pronostic.

Kaposi sarcoma (KS) is an angioproliferative condition of multifactorial etiology. Human herpes virus 8 infection is necessary, but not sufficient for the development of KS. Various genetic, social, immunologic and endocrine factors also play a role. KS encompasses four clinical subtypes: classic (sporadic) KS, endemic KS that occurs in Sub-Saharan Africa, epidemic KS, which develops in patients with human immunodeficiency virus (HIV) infection and iatrogenic KS, associated with the chronic use of immunosuppressive drugs. Unlike KS arising in HIV-pozitive patients, there is no generally accepted staging system or treatment guideline for classic KS. No systemic treatment is specifically approved for this form of the disease and randomized trials comparing drug efficacy are lacking, therefore the management of these patients often represents a real challenge for clinicians. We present the case of a 61 year-old HIV-negative male patient with no personal history of malignancy or immunos...

European Journal of Radiology, 1992

BMC Research Notes, 2015

Background: Classic Kaposi Sarcoma (KS) is vascular sarcoma, known to be more common in Mediterranean elderly men and characterized by an indolent clinical behavior. To our knowledge, this is the first evidence in literature, describing a spontaneous partial regression in a non-HIV, non-iatrogenic KS. Case presentation: A 68-years old woman, presenting with weight loss and respiratory symptoms, was diagnosed with a classic KS involving lungs and mediastinal lymph nodes. No skin or mucosal lesions were identified, HIV positivity was ruled out. Due to patient's choice, she was kept under surveillance with 3-monthly thorax-abdomen-pelvis computed tomography scan (TAP CT). A first reassessment proved progressive disease (PD) associated with symptoms worsening. A new TAP CT, performed at 5 months from the diagnosis, showed stable disease (SD), with a minor reduction in size of mediastinal lymphadenopathies. A further reassessment, performed 5 months later, resulted in a partial response (PR) despite the absence of any medical treatment. Up to date, the disease is in remission, patient is asymptomatic and still on surveillance. Conclusion: Given the possible indolent behaviour of KS, we believe that close surveillance can represent a valuable approach in selected cases.

The Journal of Dermatology, 1992

A series of 90 cases of classic Kaposi's sarcoma observed and treated over the last 25 years was examined retrospectively. Fifty-one were the localized and 39 the disseminated form. Outpatient surgery for the localized and vinblastine chemotherapy for the disseminated form are probably the best treatments. Radiotherapy may be a valid alternative.

Journal of Dermatological Case Reports, 2012

Background: Kaposi sarcoma (KS) is a vascular neoplasm with multicentric cutanenous and extracutaneous involvements, which was first described by Moriz Kaposi in 1872. Since then, different epidemiological clinical and histopathological variants of this neoplasm have been identified. Classic Kaposi sarcoma (CKS) is one of four main clinico-epidemiologiologic variants. characteristics of the disease.

Journal of the European Academy of Dermatology and Venereology, 2003

Kaposi's sarcoma (KS) is an unusual neoplasm that has proved to be an enigma in many ways since its original description in 1872. KS, a vascular tumour that is otherwise rare, is at present the most common neoplasm in patients with AIDS. The lesions contain spindle cells that share features with endothelial cells and smooth muscle cells and are in all likelihood primitive mesenchymal cells that can form vascular channels. These cells are monoclonal in origin indicating therefore that KS is a neoplasm. The presence of a novel type of human herpes virus, KS herpesvirus (KSHV) also called human herpesvirus type 8 (HHV8) in KS lesions support a viral ethiology. KS may be mistaken in the skin for an inflammatory or other lesion, thus skin biopsy is important for correct diagnosis, with the use of immunohistochemistry or molecular biology if needed. Radiation or interferon alpha dominate in the therapeutic approaches.

Acta dermato-venereologica, 1999