생약복합조성물(HemoHIM)의 자외선 조사로 억제된 랑게르한스 세포의 항원제시기능 방호효과
Uhee Jung2011, Journal of Life Science
Sign up for access to the world's latest research
checkGet notified about relevant papers
checkSave papers to use in your research
checkJoin the discussion with peers
checkTrack your impact
Abstract
In the previous results, we developed an effective products to apply as functional foods for overcome of radiation damage and reduction of side effects in radiotherapy. To verify the prevention of UVB-induced immunosuppression of immune cell function by HemoHIM, we studied on the mechanism of the skin immune function for the protection in UVB irradiation. In studies presented here, we showed that HemoHIM can prevent UVB-induced impairment of skin immune cell function by in vitro and in vivo assay. Exposure of freshly cultured murine dendritic cells (DCs) with IL-4/GM-CSF to UVB irradiation resulted in impairment of accessory function. This suppression could be prevented by addition of HemoHIM before or after to the cultures of UVB-irradiated DCs. We also tested the effects of HemoHIM on the suppression of contact hypersensitivity (CHS) treated oral or intraperitoneal administration. This UVB-suppressed CHS was prevented by administration of HemoHIM to UVB-irradiated mice. These results suggest that HemoHIM may prevent UVB-induced immune suppression in the skin.
Related papers
면실 종자의 발아억제를 위한 전처리 조건 연구
Korean Journal of Crop Science, 2013
This research study was to develop methods for inhibiting the germination of cotton seeds. Germination rates after heating treatment at 80℃ with 10, 20, 30, 40 min. were 9.3, 9.3, 5.3 and 1.3 percentage, respectively. Heat treatment over 85℃ with 10 min. caused no germination of cotton seeds. Germination was significantly reduced with gamma rays treatment more than 10,000 gy, while the treatment within 2,000-8,000 gy induced less effects. Microwave processing for 30 seconds and 60 seconds inhibit the germination of cotton seed under 8 and 0%, respectively. As a physical treatment, rollmill milling with 1.5, 2, 2.5 mm gap inhibited any germination of cotton seeds. The optimum gap of roll-mill for processing physical cracking was below 51% of the thickness of seed.
Agarase의 분류, 기원, 확보, 활성파악, 분리정제, 생산 및 응용
Journal of Life Science, 2012
Agar is a cell wall component of macro red algae that can be hydrolyzed by agarase. Agarases are classified into α-agarase (E.C. 3.2.1.158) and β-agarase (E.C. 3.2.1.81), in accordance with their cleavage pattern, and can be grouped in the glycoside hydrolase (GH)-16,-58,-86,-96, and-118 family according to the amino acid sequences of the proteins. Many agarases and/or their genes have been detected, isolated, and recombinantly expressed from bacteria, and metagenomes have their origins in sea and terrestrial environments. Products of agarases, agarooligosaccharides and neoagarooligosaccharides, represent wide functions such as antitumor, immune stimulation, antioxidation, prebiotic, hepa-protective, antibacterial, whitening, and moisturizing effects; hence, broad applications would be possible in the food industry, cosmetics, and medical fields. In addition, agarases are also used as a tool enzyme for research. This paper reviews the sources, purifications and detection methods, and application fields of agarases. The role of agarases in agar metabolism and the function of their enzymatic products are also surveyed.
희귀 수종 미선나무(Abeliophyllum distichum Nakai.)의 기내 증식 및 발근에 미치는 LED (light emitting diode) 효과
Journal of Plant Biotechnology, 2014
This study was conducted to elucidate the effect of light sources and explant types on in vitro shoot multiplication and rooting of a rare and endangered plant Abeliophyllum distichum. Both apical buds and axillary buds were used as explants under 4 different light sources, cool white florescent light (F), 100% blue light-emitting diode (LED) (B), 50% blue and 50% red LED mixture (BR), and 100% red LED (R). Clear difference was observed in terms of shoot proliferation by light sources types but not by position-dependent explant types. Multiple shoot induction rates were enhanced under both B and BR light sources. Spontaneous rooting was induced in shoot induction medium under B light source. Both the rates of rooting and numbers of roots per explant were higher in apical bud explants compared to axillary bud explants. Interestingly R light source stimulated shoot elongation but inhibited root development. Therefore, our results suggest that the use of apical bud explants under B or BR light sources is suitable for in vitro micropropagation of a rare and endangered plant species, Abeliophyllum distichum.
조피볼락(Sebastes schlegeli) 치어 사료에 오징어(Sepia esculenta) 간 분말에 대한 어분대체 효과
Korean Journal of Fisheries and Aquatic Sciences, 2013
An 8-week feeding experiment was conducted to evaluate three types of squid Sepia esculenta liver powder (SLP) as a dietary protein source for replacement of fish meal (FM) in the juvenile black rockfish, Sebastes schlegeli. For replacement of FM, six experimental diets were formulated with 5 or 10% of either of three types (A, B, C) of SLP: SLP-A 5 , SLP-A 10 , SLP-B 5 , SLP-B 10 , SLP-C 5 , and SLP-C 10. One of the control diets contained 100% FM as the protein source, and the other was a commercial diet (Com). Fish with an average body weight of 6.50 0.03 g (mean SD) were allocated randomly in triplicate groups of 50 to aquaria and fed the experimental diets until satiation. The weight gain (WG) and specific growth rate (SGR) of fish fed the FM, SLP-A 5 , SLP-A 10 , and SLP-B 5 diets were higher than those of fish fed the Com, SLP-B 10 , SLP-C 5 and SLP-C 10 diets. No significant differences were observed in WG and SGR among the diet groups, with the exception of the SLP-C 10 diet group. The feed efficiency (FE) and protein efficiency ratio (PER) of fish fed the SLP-A 5 , SLP-A 10 , and SLP-B 5 diets did not differ from those fed the control diet. However, fish fed SLP-B 10 and SLP-C 10 had lower FE and PER than the fish fed the FM, commercial, SLP-A 5, SLP-A 10, and SLP-B 5 diets. Both the SLP-A and SLP-B diets, but not the SLP-C diets, replaced up to 10% and 5% of FM for juvenile black rockfish, respectively. The results of this experiment provide information that will assist in formulating an inexpensive and practical diet containing SLP for juvenile black rockfish.
Preparation of Lignin Derivatives Substituted with 3,4-dihydroxybenzylamine and Their Application as a Biomaterial with Antioxidant and Ultraviolet Light Blocking Properties
Peolpeu jong'i gi'sul, 2022
Epoxy kraft lignin (EKL) was prepared by substituting the hydroxyl groups of kraft lignin with epoxide groups. Subsequently, 3,4-dihydroxybenzylamine (DHBA) was introduced to the prepared EKL substituted with DHBA (EKL-DHBA) to impart antioxidant and ultraviolet (UV) light blocking properties. Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and 1 H nuclear magnetic resonance spectroscopy confirmed that the DHBA moiety had been grafted successfully onto the lignin macromolecule. Additionally, 31 P NMR analysis revealed that EKL-DHBA had a higher content of phenolic hydroxyl groups than KL, owing to catechol structure substitution. EKL-DHBA/polyvinyl alcohol (PVA) films were prepared and their antioxidant and UV blocking properties were investigated. The antioxidant activity of the film prepared adding 1 wt.% of EKL-DHBA was 93.15%, which was higher than that of ethanol soluble kraft lignin (EL). Furthermore, the EKL-DHBA/ PVA film exhibited excellent UV blocking properties of approximately 96.75%-86.12% in UV-B (280-320 nm) and 86.12% in UV-A (280-400 nm) regions. Thus, the UV blocking properties of the EKL-DHBA/PVA film was much higher than that of EL or PVA film.
Isolation and Identification of Anthocyanins and Determination of Antioxidative Activity in Rice-hull of a new Cultivar, ‘Jungmo1020’
KOREAN JOURNAL OF CROP SCIENCE, 2014
Anthocyanins are water-soluble plant pigments that give rise to the red, purple, or blue colors observed in many crops. Especially purple pigment of colored rice represent biological activities has been an increased interest, due to the functional meal as a staple food. These health benefits have been attributed to antioxidant property of anthocyanin. However, there have been little genetic source for development of new and various colored rice variety. A recently developed new variety, 'Jungmo1020', showed an unique characteristic of blue color of rice grain hull. We identified the pigment petunidin-3-O-glucoside (Pt-3-G) as a major compound with a value of 176.3±2.3 mg/100 g (68.3%) from 80% MeOH with 1% HCl extracts by UPLC/MS/MS. The content of Pt-3-G in the extracts using a solvent of 100% MeOH with 1% HCl was the highest with the values of 183.8±2.5 mg/100 g. In addition, these extracts showed excellent antioxidatative activities by DPPH and ABTs assay.
Production and Properties of Hemicellulases by a Cellulosimicrobium sp. Isolate
Microbiology and Biotechnology Letters, 2011
Production and Properties of Hemicellulases by a Cellulosimicrobium sp. Isolate.
고인성 섬유보강 무시멘트 복합체의 기초 배합 및 역학 실험
Journal of the Korea Concrete Institute, 2012
Cement has been traditionally used as a main binding material of high ductile fiber reinforced cementitious composites. The purpose of this paper is to investigate the feasibility of using alkali-activated slag and polyvinyl alcohol (PVA) fibers for manufacturing high ductile fiber reinforced cementless composites. Two mixture proportions with proper flowability and mortar viscosity for easy fiber mixing and uniform fiber dispersion were selected based on alkali activators. Then, the slump flow, compression, uniaxial tension and bending tests were performed on the mixes to evaluate the basic properties of the composites. The cementless composites showed an average slump flow of 465 mm and tensile strain capacity of approximately 2% of due to formation of multiple micro-cracks. Test results demonstrated a feasibility of manufacturing high ductile fiber reinforced composites without using cement.
Effects of Artemisia A. Smoke(Ssukjahun) on Menstrual
2016
Purpose: The purpose of this study was to identify effects of Artemisia A. Smoke(Ssukjahun) on primary dysmenorrhea. Method: This study was a pretest-posttest design with a nonequivalent control group. Data were collected from May 1, 2007 to May 27, 2008. A total of 40 women with dysmenorrhea participated in the study. Among them, 20 women were assigned to an experimental group and the other 20 to a control group. Artemisia A. Smoke(Ssukjahun) was provided daily for 4 days, starting 7 days prior to next expected menses in the experimental group. The instruments used in this study included MDQ (Moos ' Menstrual Distress Questionnaire) by Kim (1995), Visual Analogue Scale by Keele (1948), and
Polymannurongte가 흰쥐의 혈청과 간장조직중의 Leptin에 미치는 영향
Korean Journal of Fisheries and Aquatic Sciences, 2003
Related topics
Related papers
Benzobicyclon 혼합제의 제형 및 처리시기가 제초활성 및 벼 생육에 미치는 영향
CNU Journal of Agricultural Science, 2013
This study was conducted to evaluate the efficacy of two different formulations and application timings of benzobicyclon+penoxsulam+pyrzaosulfuron-ethyl (BPP) in rice field. BPP granule (GR) and tablet (TB) controlled more than 90% of four weed species 10 and 15 days after sowing in direct seeding when compared with untreated control. BPP TB was highly effective to control herbicide resistant Scirpus juncoides and Monochoria vaginalis both 10 and 15 days after transplanting (DAT). BPP GR controlled 94.0 and 96.5% of S. juncoides and M. vaginalis, respectively 10 DAT, but its efficacy decreased to 88.5 and 49.8% respectively 15 DAT. When compared with untreated control, no visual injuries were detected at 255 and 510 g a.i./ha of BPP. The yield of rice increased in both BPP GR and TB in transplanting and direct seeding rice cultivation when compared with untreated control. Based on these data, early application (10 DAT) of BPP GR and TB can be applied to provide effective weed control, especially in the field infested with herbicide resistant weed species.
과채즙 식이를 포함한 혈중지질개선 프로그램의 참여도에 따른 효과
The Korean Journal of Community Living Science, 2015
Xanthine oxidase inhibitory activity of the methanolic extracts of selected Jordanian medicinal plants
Pharmacognosy Magazine, 2011
This study was performed to certify the inhibitory effect of aqueous extracts from sixty-seven medicinal plants on the activity of xanthine oxidase in vitro. Among the sixty-seven medicinal plants, Scutellaria baicalensis Georgi, Citrus aurantium L., Polygonum multiflorum Thunb., Pueraria thunbergiana (Sieb. et Zucc.) Benth., Citrus unshiu Marcor., Rubus coreanus Miquel, Camellia sinensis L., and Poncirus trifoliata Raf. were regarded as effective anti-gout sources. The active substances of P. multiflorum root extract were very stable at pH 2.0 and high temperatures. Xanthine oxidase activity was proportionally inhibited when concentrations of P. multiflorum extract increased. The aqueous extract from P. multiflorum root at a concentration of 2.0 mg/0.1 mL inhibited xanthine oxidase by 73.8%.
Japanese Quince (Chaenomeles japonica) as a Potential Source of Phenols: Optimization of the Extraction Parameters and Assessment of Antiradical and Antimicrobial Activities
Foods, 2020
The value of fruits is determined by the quantity and variety of biologically active compounds they contain, and their benefits on human health. This work presents the first study of the biochemical composition and antibacterial activity of the new Japanese quince (JQ) cultivars ‘Darius’, ‘Rondo’, and ‘Rasa’ fruits. The total phenolic content (TPC) was determined using the Folin–Ciocalteu method and each compound was identified by HPLC High Performance Liquid Chromatography. The antimicrobial activity against three Gram-positive and three Gram-negative bacteria, and one yeast strain, was evaluated by the agar well diffusion method using three different concentrations. The free radical scavenging activity was determined using DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid) methods and ranged from 99.1 to 115.9 μmolTE/100 g, and from 372 to 682 μmolTE/100 g, respectively. TPC ranged from 3906 to 4550 mgGAE/100 g, and five compounds...
A Case of Development of Vitiligo Followed by TNF-α Antagonist Treatment for Rheumatoid Arthritis
Journal of Rheumatic Diseases, 2012
Management Methods and Vascular Plants of the Ohseosan and the Bongsusan, Chungnam
Journal of the Korea Society of Environmental Restoration Technology, 2013
충남 오서산과 봉수산의 식물상 및 관리방안* 오현경 1) ․김동필 2) ․오구균 3) ․강기래 4) ․배중남 5) 1) 전북대학교 조경학과 & 한반도생태연구소․ 2) 부산대학교 조경학과 3) 호남대학교 조경학과․ 4) 부산대학교 생명산업융합연구원․ 5) 상지대학교 관광학부
강원도 해역에 시설된 인공어초의 보존상태
Journal of the Korean Society of Marine Engineering, 2008
Physico-chemical characteristics and antioxidant activity of goji fruits jam and jelly during storage
2013
We aimed to provide the basic data for the development of a beverage using the juices from bioresources from Jeju. Our results show that pH and o Bx of the bioresources ranged 2.0-6.5 and 3.3-16.8, respectively. Rubus coreanus Miquel juice had the highest total phenol content (47.3 mg gallic acid equivalent (GAE)/100 mL). Citrus sphaerocarpa juice showed higher rates of 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging (86.8%) than those of other juices. However, the oxygen radical absorbance capacity (ORAC) value (2,409.5 µM TE/mL) of Citrus sudachi Hort. ex Shirai juice was higher than those of other juices. A high correlation (R=0.7343) was observed between the pH and ORAC values for the 20 bioresources. Furthermore, a high correlation (R=0.8752) was found between the phenolic contents and DPPH radical scavenging for the 5 citrus fruits. These results suggest that the bioresources in Jeju could be used as natural antioxidants for the development of functional foods, including healthy beverages.
Cytotoxicity of Diamide and the Protective Effect of Thioredoxin on Diamide-Induced Vasculotoxicity in Vascular Endothelial Cells
Korean Circulation Journal, 2001
Background and Objectives This study was designed to examine the effects of diamide and thioredoxin TRX on vascular endothelial cells in order to clarify the mechanism by which vascular damage is mediated by oxygen free radicals. Materials and Methods The pulmonary artery endothelial cell PAEC line derived from bovine serum was cultured for 8 hours in media supplemented with various concentrations of diamide and TRX. The XTT assay, MTS assay, SRB assay, LDH activity and lipid peroxidation tests were perfomed. Results In XTT and MTS assays, diamide significantly decreased the cell viability of cultured PAEC in a dose-and time-dependent manner. Diamide showed a decrease in the amount of total protein, although it showed an increase of lipid peroxidation and LDH activity in cultured PAEC. In regards to the protective effect of TRX on diamide-induced cytotoxicity, this showed an increase of total protein, however it showed a decrease of lipid peroxidation and LDH activity. Conclusion Our results suggest that diamide has a vasculotoxic effect on cultured bovine PAEC and that TRX is very effective in the protection of diamide-induced cytotoxicity by duye to the increase of total protein and the decrease of lipid peroxidation and LDH activity in these cultures.
Antioxidant activity and protective effects of Trapa japonica pericarp extracts against tert-butylhydroperoxide-induced oxidative damage in Chang cells
2014
Recently, cancer incidence in modern society is increasing sharply. DNA damage is caused by intrinsic or extrinsic factors in the human body, cells protect themselves by defense mechanism against DNA damage. Also, Aberrant DNA and deficient DNA repair are closely associated with various diseases, including aging and cancer. Researchers are interested in search for proper materials to inhibition for DNA damage. As knew the side effects of synthetic antioxidant, some researches have been conducted about cancer prevention materials derived from nature. Root of Smilax china, in Liliaceae, is used detoxification and tumor treatments traditionally. However, studies on the inhibitory effect of DNA damage haven't progressed. In this study, antioxidant activity and protective effects on oxidative DNA damage of S. china root were confirmed, relationship between those activities and contents of phenolic compounds in plants were established. S. china root effectively removed 1,1-diphenyl-2-picryl-hydrazyl radicals and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid radicals. The quantification and identification of phenolic compounds were confirmed by high performance liquid chromatography analysis, its antioxidant activity was associated with some phenolic compounds. In addition, protective effects against hydroxyl radicals and ferrous ion-induced oxidative DNA damage were confirmed in plasmid DNA. In the cellular levels, S. china root suppressed the expression of γ-H2AX and p53 protein in NIH 3T3. Besides, S. china root suppressed H2AX and p53 mRNA levels. In conclusion, S. china root had the effect on DNA protection and antioxidant.
Loading Preview
Sorry, preview is currently unavailable. You can download the paper by clicking the button above.