Bronchogenic Cancer in Patients Under 40 Years Old

Lung Cancer, 1996

A retrospective study was performed in patients diagnosed with primary lung cancer, and admitted to the Instituto National de Enfermedades Respiratorias between 1984 to 1992. One thousand and nineteen patients were studied, 636 males and 383 females. We found a higher incidence in the group among 61-70 years of age in both sexes. The highest percentage of tumors were from the adenocarcinoma variety, followed by the epidermoid carcinoma, while the small-cell carcinoma presented a lower incidence. Smoking has been associated with the development of lung cancer. Many of our patients were smokers. The highest frequency was in smokers with a smoking habit of more than 30 years and a rate of more than 10 cigarettes per day. However, an important part of the patients with cancer did not have a smoking habit, which led us to believe that there are other etiological possibility factors (genetic or environmental) that could be involved. Most of the cases of cancer were staged as stage IIIb and stage IV and the patients had an ECOG of l-2. The main symptoms were coughing, sputum, dyspnea and thoracic pain. This data shows an increasing frequency of lung cancer in Mexico city as well as other countries, it also shows that it is going to be a serious health problem in the future. We consider that in order to improve the prognosis, it is necessary to increase the educational and orientation campaigns among the adult population with or without a smoking history.

European Scientific Journal, 2014

OBJECTIVES: To evaluate the frequency of lung cancer in the Pathology department of Sanatorio Adventista del Plata (SAP PD) Libertador San Martin, Entre Rios, Argentina during the years 1966-2010. Determine in both genders the smoking as relating it to different histological types. Verify increased adenocarcinoma. Locate the frequency of lung cancer compared to other cancers in the SAP PD. METHODS: A descriptive, retrospective study. It included 383 men and 72 women diagnosed with lung cancer, from 35 to 86 years of age, between 1966 and 2010 in the SAP PD. File Data pathology were compared with the medical records of every patient, assessing smoking. It was appealed to techniques used in immunohistochemistry. Data were processed using Excel. RESULTS: Lung cancer is prevalent in the male sex ratio of 5.3:1. Thirty six percent of male cases were squamous cell carcinoma and 54% of cases involving women were adenocarcinomas. 90% were severe smokers and 93% smoked for over 20 years. Until the decade of the 80's squamous cell carcinoma was the most frequent in the SAP PD, however, adenocarcinoma incidence increased, reaching 40% in the last decade. Of all cancers, lung cancer, does not exceed 5%, with the most frequent being skin cancer. CONCLUSIONS: Lung cancer is more common in men smokers. Adenocarcinoma rise is observed. The incidence of lung cancer in the SAP PD decreased in the last decade)

Journal of Analytical Oncology, 2012

Retrospective analysis of 101 lung cancer patients treated at the INER [National Respiratory Diseases Institute] in Mexico from January 2006 to October 2007. Objective: Analysis of clinical situation and treatment. Results: The study comprised 59 men and 42 women: 58 % > 60 years old. 14.8% were non-smokers or had no smoking history. 85.2% were heavy smokers with a smoking history above15 packs per year. Eleven patients had one family member with cancer. 86.1% of them were admitted to hospital when the tumor stage was between IIIA and IV. 21 patients of this group had metastasis. 86.1% had an ECOG grade of 0.2. Two analytical parameters were handled: RECIST and the media overall survival. 93 of 101 patients (92%) were treated with chemotherapy: 51 of them (54.7%) with Cisplatine and Paclitaxel, 29 (31.1%) with Cisplatine and Vinorrelbine, and 13 (13.8%) with Cisplatine and Gemcitabine, each one for 2 to 6 cycles. According to RECIST, 6 patients had a complete response, 19 had pr...

European Journal of Cancer Care, 2010

To examine the incidence, characteristics, therapeutic approach and survival of diagnosed lung cancer (LC) in the Santiago de Compostela Health Area. A retrospective study was carried out on LC for a period of 3 years. Of the 481 cases collected, 92.7% were male. The median age was 66.93 years. The crude incidence for men and women was 80.71 and 5.84 per 100 000 inhabitants respectively. Among the non-small cell lung cancers (NSCLC), 68.1% were diagnosed in stage IIIB or IV. The cancer had already spread in 62.2% of the small cell lung cancer (SCLC). Chemotherapy was used in 51.6% of patients. The survival probability from the first to the fifth year was 47.7%, 24.3%, 12.9%, 10% and 8.9% respectively. The median survival at 5 years was 12.12 months for NSCLC, rising to 29.8 months in stage I, and 8.85 months in SCLC. In our Health Area LC occurs more often in men, in whom the prevalence of smoking is very high. The most common histology type was squamous cell carcinoma. In the majority of cases, the diagnosis is made in the advanced stages, which accounts for the low percentage of surgical treatments and the short survival.

Salud Pública de México, 2019

Objective. To show lung cancer (LC) mortality and disability-adjusted life years (DALYs) in Mexico. Materials and methods. With the visualization tools at the Global Burden of Disease Study website, we analyzed LC mortality and disability-adjusted life years (DALYs) by state, sex, sociodemographic index (SDI), age, and risk factors between 1990 and 2016. Results. Mortality rate decreased from 13.9 to 9.1 per 100 000 between 1990 and 2016. This reduction is greater among men. However, deaths by LC rose from 5 478 to 8 470. DALYs rate also decreased. Northern states with higher SDI face a larger burden from LC but exhibited greater reductions compared with southern, less developed states. The burden of LC is concentrated among older population. Smoking is the main risk factor for LC. Conclusions. The burden by LC has decreased but is differential between states. LC threatens financially both the health system and individuals, since an important fraction of the population is not protected.

CHEST Journal, 1993

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Puerto Rico Health Sciences Journal, 2012

2011

Objective: Major changes in the incidence of the most common histological types of lung and bronchus cancer have been observed around the world. herein we report the overall incidence, stage at diagnosis and overall mortality of lung and bronchus cancer in Puerto rico, and the incidence of the different histologic types. Methods: aggregate lung and bronchus cancer data from 1987 to 2003 were obtained from the Puerto rico central cancer registry. incidence and mortality rates were age-standardized by the direct method to the 2000 standard population of the united states. for the incidence (overall, by histologic type, and by sex), and mortality we calculated the annual percent change (aPc) using the Joinpoint regression Program. results: there were 9,886 cases of lung and bronchus cancer (6,772 men, 3,114 women), for an overall age-adjusted incidence of 18.8 per 100,000. the incidence decreased significantly for the whole group, falling from 18.9 per 100,000 in 1987 to 17.1 in 2003 (...

2007

Objective: To describe the mortality trends for lung cancer, cancer of the trachea, and bronchial cancer in relation to gender and age brackets in Brazil. Methods: Data related to mortality between 1980 and 2003 were collected from the Brazilian Mortality Database. A trend analysis of mortality was carried out, nationwide and in selected states, using the LOWESS technique for rate smoothing and model adjustments. Results: In Brazil, the standardized mortality rate for lung cancer, cancer of the trachea, and bronchial cancer increased from 7.21/100,000 inhabitants in 1980 to 9.36/100,000 inhabitants in 2003. Specific mortality rates decreased in males in the 30-49 and 50-59 age brackets. In the 60-69 age bracket, the rates for males increased from 1980 to 1995 and declined thereafter. There was a trend toward higher mortality rates in males over 70, as well as in females over 30, throughout the period evaluated. Conclusions: The decrease in the mortality rates in younger males might have resulted from recent national interventions aimed at reducing the prevalence of smoking and reducing exposure in younger cohorts. High mortality rates in older populations remained constant due to prior tobacco use. Increased mortality rates in females are a worldwide trend and are attributable to the recent increase in smoking prevalence in females.

Chinese Journal of Lung Cancer, 2018

Background Changes in lung cancer has been characterized by the increase of cases among women and the increase in adenocarcinomas among other histological subtypes. Methods Descriptive analysis of cases diagnosed with lung cancer in Hospital Virgen de las Nieves (Spain) from 1990 to 2010, based on five variables (age, sex, smoking, histology and pathological anatomy). The study establishes associations between these variables and compares the results with the literature. Results 2, 026 patients were diagnosed with lung cancer in this period; 1, 838 were males (90.7%) and 188 women (9.3%); 1, 892 patients (93.4%) were smokers or ex-smokers and 134 (6.6%) had never smoked; the most frequent non-small cell histology types were squamous cell carcinoma and adenocarcinoma and it was the most frequent neoplasia in women and were associated with a lower tobacco consumption. Conclusion The large majority of lung cancer cases is associated with a history of smoking tobacco and there are histo...