Sweet Syndrome in childhood

Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is characterized by fever, elevated white blood cell counts predominantly composed of neutrophils, painful red plaques on the skin, and dermal neutrophilic infiltration without vasculitis. SS can be triggered by various factors and is diagnosed based on clinical, laboratory, and histopathological criteria. SS is classified into three types: classical (or idiopathic), malignancy-associated, and drug-induced. Classical Sweet syndrome is the most common form, often linked to infectious diseases, inflammatory disorders, or pregnancy. This case report describes a patient with an aggravated and generalized form of Sweet syndrome who had a favorable outcome following appropriate treatment.

Journal of Investigative Medicine High Impact Case Reports

Sweet’s syndrome, also known as acute febrile neutrophilic dermatosis, is a rare disorder that typically presents with rapid appearance of tender skin lesions accompanied by fever and leukocytosis with neutrophilia. Its pathogenesis is not fully understood. The syndrome is generally classified into classical, malignancy-associated, and drug-induced categories, each of which has its specific characteristics. In this article, we present a case of classical Sweet’s syndrome in a woman who presented with an acute viral illness.

PEDIATRICS, 2012

Current Health Sciences Journal, 2020

Introduction. Sweet syndrome (SS), also denominated as acute febrile neutrophilic dermatosis, is a rare disease characterized by the sudden onset of painful, erythematous, firm skin lesions (papules, plaques, and nodules) which show, upon histologic examination, the presence of a diffuse infiltrate of mature neutrophils. The cutaneous manifestation typically involves the face, neck, trunk, and upper limbs and is associated with fever, general malaise, arthralgia. Case report. A female patient, 60 years old, attended the Dermatology Clinic due to the appearance of violaceous erythematous-oedematous infiltrated plaques, located on the face, neck, upper limbs, trunk and knees. The onset of the cutaneous manifestation had occurred 2 months prior, accompanied by pain, chills, flares of fever and arthralgia. The onset coincided with the surgical treatment of an umbilical hernia. From the medical history we note that the patient was diagnosed in 2014 with histiocytoid SS. She followed a tr...

Acute neutrophilic dermatosis, first described in 1964 by Robert Douglas Sweet, is characterized by sudden onset fever, neutrophilic leukocytosis, and well demarcated erythematous papules, nodules, and plaques with dense neutrophilic infil- trates on histologic evaluation. Here is a report of a 7-year-old girl who presented with high grade fever, and discrete erythematous papular skin erup- tions, which gradually increased in number and involved the face, trunk, extremities, palms, soles, hard palate, and palatal tonsils. The skin eruptions evolved to pustules and after coa- lescing caused large crusted plaques, with mild tenderness but without any pruritus. White blood cells were 36900/ml with 92% neutrophils. Skin biopsy test was compatible with acute febrile neutrophilic dermatosis, so prednisolone (1 mg/kg/day) was started that led to a rapid defervescence and significant improvement of dermatosis. After a few days, the patient pre- sented with fever and arthritis of right elbow...

Bangladesh Journal of Medical Science

We present a case of a patient with Sweet Syndrome secondary to possible bacterial infection. The diagnosis of Sweet Syndrome was made based on his clinical and histopathological findings. Sweet syndrome is a rare inflammatory disorder characterised by tender erythematous skin lesions, often accompanied with fever, neutrophilia and leukocytosis. It is generally classified into classical (or idiopathic), drug-induced or malignancy-associated, each of which has its own features. Bangladesh Journal of Medical Science Vol. 21 No. 04 October’22 Page : 922-925

Rheumatology

Background Sweet syndrome (acute febrile neutrophilic dermatosis) is a rare inflammatory disorder affecting individuals between the ages of 30 and 60. It is characterised by painful, edematous, and erythematous skin papules, plaques, or nodules. Fever and leukocytosis (neutrophilia) frequently accompany the skin lesions. A majority of cases are idiopathic but there is a significant proportion attributed to malignancy or medications. Our case is peculiar because of an unusual presentation of a 12-month history of undifferentiated inflammatory arthritis before manifestation as Sweet syndrome. The mainstay of treatment is corticosteroids, although spontaneous resolution has been reported. Treatment of an underlying medical cause may lead to an improvement in Sweet syndrome. Methods A 57-year old British male presented with a 1-year history of intermittent joint pain and swellings in both upper and lower limbs. He had been treated with short courses of oral corticosteroids for undiffere...

International Journal of Homoeopathic Sciences, 2021

Sweet syndrome aka acute febrile neutrophilic dermatosis is one of the serious dermatological condition which goes undiagnosed due to several reasons. Unawareness of this condition may be one of the primary factors for missing the diagnosis which may lead to inaccurate treatment which may only lead to worsening the condition in a sick individual. Very few studies have been published in this area, hence the present investigator felt the need of reviewing few literatures and creating a material which will aid in early and accurate diagnosis of the condition. About 20 literature was reviewed based on the history, presentation, diagnosis and its probable homoeopathic treatment accordingly. All the information required for accurate diagnosis and its homeopathic approach was compiled into the present paper.

Advances in Dermatology and Allergology, 2014

Diagnosis of paraneoplastic skin syndromes associating neoplastic processes is assumed as the crucial aspect of dermatological practice. Knowledge of clinical findings of dermatoses suggesting coincidence of malignant proliferative processes facilitates diagnostic and therapeutic procedures. We would like to present a case of Sweet's syndrome, qualified for comparative paraneoplastic skin syndromes. Sweet's syndrome, acute, febrile neutrophilic dermatosis, was first described by Robert Douglas Sweet in 1964 as a disorder characterized by fever, skin lesions of erythematous-infiltrative character, leukocytosis with neutrophilia and dense infiltrations of dermis by mature neutrophils. Sweet's syndrome aetiology is not fully understood, although cytokine abnormalities suggest that Th1 lymphocytes play an important role in pathogenesis of the dermatosis. Factors inducing Sweet's syndrome include: haematopoietic hyperplasia; neoplasms: genitourinary, breast, gastrointestinal; infections of the respiratory and alimentary system; inflammatory bowel diseases; drugs; pregnancy and vaccinations. Systemic corticosteroids are the "gold standard" of Sweet's syndrome treatment; potassium iodide or colchicine may also be used. Indomethacin, clofazimine, cyclosporine A and sulfones are the second-line drugs.

International journal of research and review, 2023

Sweet's Syndrome, also known as acute febrile neutrophilic dermatosis is a rare disease of unknown etiology, but has been associated with autoimmune processes, malignancies, infections, GI disorders and drug reactions. It is more prevalent in women than men, except in case of malignancy associated origin. Clinical features of this disorder include acute onset of painful plaques on skin, neutrophilic leukocytosis, fever, dermal infiltrations by neutrophils. Usually, sweet's syndrome is presented in three main clinical settings which includes: the classical (idiopathic), malignancyassociated, and drug induced. Classical Sweet's Syndrome (CSS) is usually seen in women between the age of 30 to 50 years. It is frequently preceded by an upper respiratory illness and could be linked to pregnancy, inflammatory bowel disease, and both. Recurrence of the dermatosis is usually seen in one third of the patients experiencing classical sweet's syndrome. Malignancy associated Sweet's Syndrome (MASS) is usually present in patients with confirmed cancer and manifested as a paraneoplastic syndrome. Also occurs in those whose solid tumor or hematologic dyscrasia associated with sweet's syndrome was previously undetected. Drug induced Sweet's Syndrome (DISS) occurs in patients being treated with granulocyte-colony stimulating factor. Various other drugs including antibiotics like Minocycline, Trimethoprim Sulfamethoxazole, nitrofurantoin, antiepileptics like Carbamazepine, Diazepam, NSAIDS, Diuretics and Retinoids can also cause DISS. Diagnosis of sweet syndrome is usually done by two major criteria (histopathology and acute cutaneous lesion), and four minor criteria's (infection, malignancy, medications, fever, and extra cutaneous manifestations like leukocytosis and corticosteroid response. Systemic corticosteroids are the golden standard of treatment for Sweet's Syndrome. Systemic corticosteroids (0.5mg to 1mg/kg/day) for 4-6 weeks improves the systemic symptoms and reduce the skin lesions. For treating localized lesions, topical application of high potency corticosteroids or intralesional corticosteroids are effective. Other first line agents including potassium iodide and colchicine are also used. Second line agents include Indomethacin, Cyclosporine, Dapsone and Clofazimine.

Pediatric dermatology, 2011

The objective of this study was to describe the clinical features of Sweet syndrome in children. Our study population consisted of seven children diagnosed with Sweet syndrome over a 22-year period. Age, sex, appearance and location of lesions, associated signs and symptoms, past medical history, pathology, and subsequent disease course were documented for each patient. Fever and typical lesions were reported in most of patients in our study. The majority of patients presented with less-typical findings, such as pustules, vesicles, bullae, oral ulcerations, atrophic scars, and evidence of pathergy. Of the seven children in our study, four were found to have a preceding nonspecific upper respiratory or gastrointestinal infection, and two were diagnosed with an underlying hematologic malignancy. Our results suggest that atypical lesions are relatively common in children with Sweet syndrome and that underlying malignancy is associated with a minority of cases of pediatric Sweet syndrome.

Clinical Medicine & Research, 2011

International journal of dermatology, 2010

Sweet's syndrome (SS) is an uncommon disorder characterized by the abrupt onset of erythematous papules and plaques that histologically exhibit diffuse dermal neutrophilic infiltrate and edema. There are usually associated constitutional symptoms such as fever, neutrophilia, elevated serum inflammatory markers, and associated disorders. The aim of this study was to assess the clinical and histologic features of all patients diagnosed with SS at our institution between 1971 and 2008 and to compare their findings with those published in the literature. Retrospective review of 44 cases of SS diagnosed at the American University of Beirut - Medical Center between 1971 and 2008. Data collected included clinical (age, gender, morphology and distribution of lesions, associated symptoms and disorders, therapy) and histologic features, as well as laboratory abnormalities. Most of our patients showed the typical clinical, histologic, and laboratory abnormalities characteristic of SS. Of o...

International Journal of Research in Dermatology, 2017

Sweet's syndrome (SS) or acute febrile neutrophilic dermatoses was originally described by Robert Douglas Sweet in 1964. It is characterized by fever, leucocytosis, and sudden onset of painful, erythematous papules, nodules or plaques histopathologically characterized by a dense dermal infiltrate of neutrophils with prominent papillary dermal oedema sometimes severe enough to produce subepidermal vesiculation or bullae. This condition is highly responsive to corticosteroids. 2 There are various clinical subtypes of SS which include classical or idiopathic, respiratory or gastrointestinal tract infection related, drug induced, autoimmune disease

Journal of Neurology, 1996

Association of Sweet's syndrome (SS) with solid tumours is found in about 15% of all malignancyassociated cases, but an association with two malignancies occurring in the same patient has been rarely reported. In the present report, we describe an 82-year-old male with SS in association with adenocarcinoma of the prostate and transitional cell carcinoma of the urinary bladder.