GOKANAPALLE ANUSHA
My research focuses on the synthesis and development of small molecules for the treatment of Toxoplasmosis, a parasitic infection caused by Toxoplasma gondii. My background in organic chemistry and medicinal chemistry has equipped me with a strong foundation in designing and synthesizing novel compounds with potential therapeutic applications. During my postdoctoral research I worked on optimization of potent phosphodiesterage inhibitors for the treatment of cryptosporidium. And my doctoral studies at Yogi Vemana University, I synthesized and developed various M_NHC catalysts and applied their catalytic activity for different coupling reactions. The prepared heterocyclic compounds were tested for Alzheimer disease. This experience provided a strong foundation in drug design and development.
Supervisors: James W. Janetka
Phone: +13146679257
Address: 3307 Olive street
Apt 403
saint louis, MO 63103
Supervisors: James W. Janetka
Phone: +13146679257
Address: 3307 Olive street
Apt 403
saint louis, MO 63103
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Papers by GOKANAPALLE ANUSHA
trimethylbenzyl and 2,4,6‐triisopropylbenzyl substituents have been designed
and synthesized from various o‐phenylenediamines. Subsequently, corresponding
Cu‐based N‐heterocyclic carbenes (NHCs) were generated in situ in the
reaction medium which represents a new application of NHCs exploiting distinct
catalytic property towards intermolecular cyclization reaction cascade
for the synthesis of 2‐aryl‐3‐(arylethynyl)quinoxalines from ophenylenediamines
and terminal alkynes. The outcome of the cyclization reaction
product depends upon the N,N′‐substituents present on the
benzimidazolium chlorides.
trimethylbenzyl and 2,4,6‐triisopropylbenzyl substituents have been designed
and synthesized from various o‐phenylenediamines. Subsequently, corresponding
Cu‐based N‐heterocyclic carbenes (NHCs) were generated in situ in the
reaction medium which represents a new application of NHCs exploiting distinct
catalytic property towards intermolecular cyclization reaction cascade
for the synthesis of 2‐aryl‐3‐(arylethynyl)quinoxalines from ophenylenediamines
and terminal alkynes. The outcome of the cyclization reaction
product depends upon the N,N′‐substituents present on the
benzimidazolium chlorides.