Create an Interactive Map using HTML5

Is there an easy way to display a map on my WordPress site? I guess I need a HTML5 map in order to support mobile devices.

Here is what I need with the interactive map: to be zoomed, paned, etc (alike Google Maps) and on this map I want to display some custom regions and pinpoint specific location, and display a speech box alike popup when a pin/button is pushed on the map?

Any HTML5 compatible interactive map would be recommended for this purpose?

I know I can do this with some XML-based map and write some of the scripting myself, and maybe using google API. However I need this solution to be very easy so that my assistant (not technical savvy) can also help me to maintain it.

I tried the iMap’s HTML5 Map software which works pretty close to what I need, however its needs a desktop software. I would prefer a open source solution if possible.

Compatibility with PC, Mac, Android, iPhone and iPad is needed as my blog is visited by users with all types of devices.