STX-1150 is a novel liver-targeted therapy designed to epigenetically silence PCSK9 and durably reduce low-density lipoprotein cholesterol (LDL-C) without permanent DNA changes ... About PCSK9 and its Role in Elevated LDL-C.
SHANGHAI and SANTA BARBARA, Calif., Dec ... RN5681 is a GalNAc-conjugated, dual-targeting siRNA designed to simultaneously silence both PCSK9 and LPA, two genetically validated and complementary drivers of atherosclerotic cardiovascular disease ... Dr ... 21% ... .