AC Immune Initiates Phase 1 Clinical Trial of NLRP3Inhibitor · ACI-19764 is an orally available highly brain-penetrant small molecule NLRP3 inhibitor. · NLRP3 inhibitors are a major new class of ...
... breast cancer who are eligible to receive a PARP inhibitor ... "Importantly, breast cancer patients with a BRCA mutation often develop resistance to treatment with a PARP inhibitor alone.
Whether evaluating the pooled data or 100mg Phase 3 formulation data, PFS was two or nearly three times longer relative to published data from studies with the only marketed HIF-2a inhibitor in the same patient population.”.
Artios receives FDA Fast Track designation for DNA polymerase theta (Polθ) inhibitor ART6043 for treatment of gBRCA-mutated HER2-negative breast cancer ... .
Experts at CincinnatiChildren's report proof-of-concept results that may sharply reduce the risk of a lethal side effect that has negatively impacted the use of revolutionary cancer immunotherapies ....
Results from the independent validation cohort demonstrated that approximately 30 percent of patients studied were identified by the AdvanceAD-Tx test as having a JAKInhibitor Responder Profile.
Approval of JAKInhibitors...Emergence of OX40L and IL-2 Inhibitors. Emerging therapies, including OX40L and IL-2 inhibitors, are strengthening the alopecia areata landscape by targeting the disease's root causes and offering precision in treatment.
CDI-988 was designed and developed using the Company's proprietary structure-based drug discovery platform technology as a pan-viral protease inhibitor, targeting 3CL viral proteases.