Papers by dominic Hodgson
American Journal of Roentgenology, 2008
The purpose of this study was to investigate whether combining percutaneous ethanol injection (PE... more The purpose of this study was to investigate whether combining percutaneous ethanol injection (PEI) with radiofrequency ablation in the management of hepatocellular carcinoma (HCC) in high-risk locations improves treatment outcomes. We compared the outcome of management of high-risk tumors with PEI and radiofrequency ablation (n = 50) or radiofrequency ablation alone (n = 114) with the outcome of radiofrequency ablation of non-high-risk tumors (n = 44). We also compared the survival rates of patients with and those without high-risk HCC. PEI was performed into the part of the tumor closest to a blood vessel or vital structure before radiofrequency ablation. The study included 142 patients with 208 HCCs managed with radiofrequency ablation. Despite larger tumor sizes (2.8 +/- 1 cm vs 1.9 +/- 0.7 cm vs 2.5 +/- 0.1 cm for the high-risk radiofrequency plus PEI, non-high-risk radiofrequency, and high-risk radiofrequency groups, respectively; p < 0.001), the primary effectiveness rate of high-risk radiofrequency ablation and PEI (92%) was similar to that of non-high-risk radiofrequency ablation (96%). The primary effectiveness rate of high-risk radiofrequency ablation and PEI was slightly higher (p = 0.1) than that of high-risk radiofrequency ablation (85%). The local tumor progression rates (21% vs 33% vs 24% at 18 months) of the three respective groups were not statistically different (p = 0.91). Patients with and those without high-risk tumors had equal survival rates (p = 0.42) after 12 (87% vs 100%) and 24 (77% vs 80%) months of follow-up. Independent predictors of primary effectiveness were a tumor size of 3 cm or less (p = 0.01) and distinct tumor borders (p = 0.009). Indistinct borders (p = 0.033) and non-treatment-naive status of HCC (p = 0.002) were associated with higher local tumor progression rates. The only predictor of survival was complete ablation of all index tumors (p = 0.001). The combination of radiofrequency ablation and PEI in the management of HCC in high-risk locations has a slightly higher primary effectiveness rate than does radiofrequency ablation alone. A randomized controlled study is warranted.
Trends in Urology & Men's Health
The popularity of neonatal circumcision has declined significantly in the last half century in th... more The popularity of neonatal circumcision has declined significantly in the last half century in the UK, but it persists in the USA where most boys are still circumcised soon after birth. In this article the author considers why the practice is now so different in the two countries and explores the pros and cons of neonatal male circumcision.
Journal of Clinical Urology
Objectives: A retrospective study was conducted to examine the feasibility and safety of performi... more Objectives: A retrospective study was conducted to examine the feasibility and safety of performing trans-urethral resection of bladder tumour (TURBT) in newly diagnosed patients as a day case operation. Patients and methods: All patients who underwent a primary TURBT over a 12 month period were included. Data were collected on patient demographics, tumour characteristics, day case vs. inpatient admission, indications for inpatient admission, re-admission rates within 28 days, and surrogate markers for quality of resection including recurrence rates. Results: A total of 172 patients were included. TURBT was performed as a day case procedure on 138 patients (80.2%). Rates of re-admission within 28 days were 7.2% and 5.9% in the day case and inpatient cohorts respectively. One hundred and thirty (75.6%) patients had non-muscle invasive bladder cancer (NMIBC). Of these, 84 (64.6%) were found to have detrusor muscle in their specimens, and 86 (66.2%) received peri-operative mitomycin C....
European Urology Supplements
European urology, Jan 28, 2018
There is no effective intravesical second-line therapy for non-muscle-invasive bladder cancer (NM... more There is no effective intravesical second-line therapy for non-muscle-invasive bladder cancer (NMIBC) when bacillus Calmette-Guérin (BCG) fails. To compare disease-free survival time (DFS) between radiofrequency-induced thermo-chemotherapy effect (RITE) and institutional standard second-line therapy (control) in NMIBC patients with recurrence following induction/maintenance BCG. Open-label, phase III randomised controlled trial accrued across 14 centres between May 2010 and July 2013 (HYMN [ClinicalTrials.gov: NCT01094964]). Patients were randomly assigned (1:1) to RITE (60min, 40mg mitomycin-C, 42±2°C) or control following stratification for carcinoma in situ (CIS) status (present/absent), therapy history (failure of previous induction/maintenance BCG), and treatment centre. Primary outcome measures were DFS and complete response (CR) at 3 mo for the CIS at randomisation subgroup. Analysis was based on intention-to-treat. A total of 104 patients were randomised (48 RITE: 56 control...
Prosthetic Surgery in Urology, 2016
There have been attempts to recreate the appearance and function of the genito-urinary tract with... more There have been attempts to recreate the appearance and function of the genito-urinary tract with exogenous materials for millennia; but it is only within the last half century that real success has been achieved. This has been a result, to a large extent, of advancements in material science to provide inert yet pliable products. However, materials which are both resistant to infection and offer sustained functionality are still sought. In this chapter we explore how urologists worked in conjunction with industry to develop effective prosthetic solutions to: testicular absence or loss, erectile dysfunction, urinary incontinence, and strictures within the urinary tract.
European Urology Supplements, 2014
European Urology Supplements, 2002
The Journal of Urology, 2014
Journal of the Royal Society of Medicine, 2005
Spermatorrhoea, the involuntary loss of semen, is in Western medicine a complaint peculiar to the... more Spermatorrhoea, the involuntary loss of semen, is in Western medicine a complaint peculiar to the 19th century. The disease was championed by Professor Claude-Francois Lallemand, from Montpellier. In 1835, citing masturbation as a major cause, he wrote that the condition 'degrades man, poisons the happiness of his best days, and ravages society'. In England, for fifty years, doctors, patients and social commentators alike took a frenzied interest in the condition. It was only at the end of the century, when the likes of Sir James Paget questioned the very existence of spermatorrhoea, that it faded from prominence.
Journal of Neurology, Neurosurgery & Psychiatry, 1999
International Journal of Clinical Practice, 2006
Prostate cancer remains a most intriguing condition, which poses unique challenges. On reviewing ... more Prostate cancer remains a most intriguing condition, which poses unique challenges. On reviewing recent literature on localised disease (confined within the capsule T1 or T2, N0, M0), it would seem that it is over treated, resulting in significant morbidity. We now have strong evidence, however, that there can be mortality associated with 'watchful waiting'. Clinicians should, therefore, aim to identify men at risk of progression in order that they should be treated effectively with minimal adverse effects. In this paper, we report on recent developments in the expanding array of management options available.
British Journal of Medical and Surgical Urology, 2011
British Journal of Medical and Surgical Urology, 2012
BJU International, 2007
Animal studies using the highly metastatic Dunning R3327 model in rats showed that HIFU could be ... more Animal studies using the highly metastatic Dunning R3327 model in rats showed that HIFU could be used to destroy prostatic carcinoma without causing metastasis (2,3). Subsequent canine studies showed that foci could be applied transrectally to the prostate without damaging the rectal wall (4). Initial in vivo human studies showed defined margins of tissue necrosis in benign tissue before a
British Journal of Medical and Surgical Urology, 2011
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Papers by dominic Hodgson