Michael Zeleznik

University of Utah, Computer Science, Alumnus

Indiana University of Pennsylvania, Physics, Alumnus

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I am a highly experienced software and system architect, developer, and project leader with a solid track record of achieving results. For over 35 years I have tackled increasingly complex, cross-discipline projects, and created timely, effective solutions in commercial, clinical, and academic environments. I know what it takes to turn vague, or seemingly intractable requirements into viable solutions or products. I have piloted such projects through the full software development life cycle, and have worked extensively in all phases, from research to development to documentation to customer support. As such, I have a solid understanding of the whole picture, from the 40,000-foot view down to the nuts & bolts in the trenches. A natural planner, organizer and leader, I am self-motivated and results oriented. Quickly adapting to new endeavors, I hit the ground running and rapidly make an impact. This is facilitated by my in-depth, hands-on experience in a broad range of technologies and work environments, coupled with my formal background in Computer Science, Physics, Mathematics, and Electronics.

Ph.D. -- Computer Science, University of Utah -- Security design in distributed computing

M.S. -- Computer Science, University of Utah -- Networking and distributed systems

B.S. -- Physics (Mathematics minor), Indiana Univ. of PA -- Focus on analog & digital electronics

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James Elkins

School of the Art Institute of Chicago

B. Harun Küçük

University of Pennsylvania

Vinicius Garcia

Universidade Federal de Pernambuco

Sinem Aslan

Università degli Studi di Milano-Bicocca

Càndid Reig

Universitat de València

Maurizio Forte

Duke University

David Seamon

Kansas State University

J. H. Chajes

University of Haifa

Remo Caponi

University of Cologne

Amir Manbachi

Johns Hopkins University

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Papers by Michael Zeleznik

A Portable, Network-Transparent Communication System for Message-Based Applications

Icdcs, 1986

Abstract A portable, network-transparent communication system (NTCS) has been developed, which su... more

A portable, network-transparent communication system for message-based applications

Proc. of the 6th International Conference on …, 1986

A portable, network-transparent communication system (NTCS) has been developed, which supports th... more

Model studies on segmental movement in lumbar spine using a semi-automated program for volume fusion

Computer aided surgery : official journal of the International Society for Computer Aided Surgery, 2008

To validate a new non-invasive CT method for measuring segmental translations in lumbar spine in ... more To validate a new non-invasive CT method for measuring segmental translations in lumbar spine in a phantom using plastic vertebrae with tantalum markers and human vertebrae. One hundred and four CT volumes were acquired of a phantom incorporating three lumbar vertebrae. Lumbar segmental translation was simulated by altering the position of one vertebra in all three cardinal axes between acquisitions. The CT volumes were combined into 64 case pairs, simulating lumbar segmental movement of up to 3 mm between acquisitions. The relative movement between the vertebrae was evaluated visually and numerically using a volume fusion image post-processing tool. Results were correlated to direct measurements of the phantom. On visual inspection, translation of at least 1 mm or more could be safely detected and correlated with separation between the vertebrae in three dimensions. There were no significant differences between plastic and human vertebrae. Numerically, the accuracy limit for all th...

Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame?

by Michael Zeleznik and Henrik Lundblad

Scientific World Journal, 2014

Monitoring and quantifying bone remodeling are of interest, for example, in correction osteotomie... more Monitoring and quantifying bone remodeling are of interest, for example, in correction osteotomies, delayed fracture healing pseudarthrosis, bone lengthening, and other instances. Seven patients who had operations to attach an Ilizarov-derived Taylor Spatial Frame to the tibia gave informed consent. Each patient was examined by Na 18 F PET/CT twice, at approximately six weeks and three months after the operation. A validated software tool was used for the following processing steps. The first and second CT volumes were aligned in 3D and the respective PET volumes were aligned accordingly. In the first PET volume spherical volumes of interest (VOIs) were delineated for the crural fracture and normal bone and transferred to the second PET volume for SUV max evaluation. This method potentially provides clinical insight into questions such as, when has the bone remodeling progressed well enough to safely remove the TSF? and when is intervention required, in a timelier manner than current methods? For example, in two patients who completed treatment, the SUV max between the first and second PET/CT examination decreased by 42% and 13%, respectively. Further studies in a larger patient population are needed to verify these preliminary results by correlating regional Na 18 F PET measurements to clinical and radiological findings.

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The KTeV hardware cluster counter

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1996

We have designed and built a trigger processor that determines the number of isolated showers dep... more We have designed and built a trigger processor that determines the number of isolated showers deposited in the electromagnetic calorimeter of the KTeV detector. Our algorithm takes advantage of pattern recognition and parallel processing techniques to increase its speed relative to more conventional cluster finding algorithms. With a relatively modest clock speed of 20 MHz, this processor reaches a decision in under 2 Ixs.

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Standard Orientation of the Pelvis: Validation on a Model and Ten Patients

Acta Radiologica, 2005

To validate an image post-processing method for re-orienting the pelvis in CT volumes to a standa... more To validate an image post-processing method for re-orienting the pelvis in CT volumes to a standardized orientation in a model and in 10 patients. Twenty-four CT volumes of a pelvic model and 10 pairs of postoperative total hip arthroplasty (THA) patient CT scans were rotated to a defined pelvic standard orientation and the rotation was recorded. For precision, a test-retest procedure was used. For accuracy, three exactly represented coordinate points were used. For clinical application, the standard orientation was used for calculating the direction of acetabular cup migration from a previous model study. Precision of pelvic standard orientation, calculated as maximal directional error, was better than 1 degrees in the model study and better than 1.5 degrees in the patient study. Accuracy, expressed as angle between ideal and measured coordinate axes, was 0.1 degrees for x, y, z axes. No measurable systematic errors were found. When applied to acetabular cup migration in the model, standardization of pelvic orientation had no significant effect on the measurements. Reorienting the pelvis during image post-processing was shown to be accurate. It enables measurements relative to the pelvis and minimizes the dependency of patient positioning.

Stability of Acetabular Axis after Total Hip Arthroplasty, Repeatability Using CT and A Semiautomated Program for Volume Fusion

Acta Radiologica, 2003

Purpose: To validate a CT method for detecting changes in acetabular cup orientation after THA.

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Model Studies on Acetabular Component Migration in Total Hip Arthroplasty using Ct and a Semiautomated Program for Volume Merging

Acta Radiologica, 2003

Purpose: Validation of a non-invasive CT method for detection of acetabular cup migration after t... more

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Spatial component position in total hip arthroplasty: Accuracy and repeatability with a new CT method

Acta Radiologica, 2003

Purpose: 3D detection of centerpoints of prosthetic cup and head after total hip arthroplasty (TH... more

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Acetabular component migration in total HIP arthroplasty using CT and a semiautomated program for volume merging

Acta Radiologica, 2002

Purpose: To develop a non-invasive method for detection of acetabular cup

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A new technique for diagnosis of acetabular cup loosening using computed tomography: Preliminary experience in 10 patients

Acta Orthopaedica, 2008

Considerable migration of the acetabular cup is required for diagnosis of loosening by convention... more Considerable migration of the acetabular cup is required for diagnosis of loosening by conventional radiography. We have developed a new clinically applicable method for assessment of cup loosening using computed tomography (CT). 10 patients scheduled for revision hip replacement due to suspected wear or loosening were scanned twice with CT under torsion loading of the prosthesis. Two independent examiners assessed each patient with respect to motion of the acetabular cup relative to the pelvis using CT volume registration. The CT measurements were compared to findings at revision surgery. The method was applicable in 8 of the 10 patients. 1 patient had a severe tremor. In 1 patient, surgery revealed that the hip was ankylotic due to massive ectopic bone formation. This left 8 patients that could be evaluated. 4 cups were loose at surgery, and 3 of these cups could be seen to be mobile by CT. 4 cups that were stable on revision were accurately diagnosed as not being mobile by CT. Movements of less than 1 millimeter between bone and prosthesis could not be distinguished from errors in CT acquisition and volume registration. There was good agreement between the two observers. Movement of loose acetabular cups during torsion loading could be detected using CT volume registration. It was sensitive to cup movement in 3 out of 4 cases of loose cups. The method was specific and yielded no false positive results.

Accuracy and Precision of Three-Dimensional Low Dose CT Compared to Standard RSA in Acetabular Cups: An Experimental Study

BioMed research international, 2016

Background and Purpose. The gold standard for detection of implant wear and migration is currentl... more Background and Purpose. The gold standard for detection of implant wear and migration is currently radiostereometry (RSA). The purpose of this study is to compare a three-dimensional computed tomography technique (3D CT) to standard RSA as an alternative technique for measuring migration of acetabular cups in total hip arthroplasty. Materials and Methods. With tantalum beads, we marked one cemented and one uncemented cup and mounted these on a similarly marked pelvic model. A comparison was made between 3D CT and standard RSA for measuring migration. Twelve repeated stereoradiographs and CT scans with double examinations in each position and gradual migration of the implants were made. Precision and accuracy of the 3D CT were calculated. Results. The accuracy of the 3D CT ranged between 0.07 and 0.32 mm for translations and 0.21 and 0.82° for rotation. The precision ranged between 0.01 and 0.09 mm for translations and 0.06 and 0.29° for rotations, respectively. For standard RSA, the...

Clinical Application of a Semiautomatic 3D Fusion Tool Where Automatic Fusion Techniques Are Difficult to Use

Proceedings of the Third International Conference on Biomedical Image Registration, 2006

ABSTRACT The purpose of this paper is to demonstrate the clinical advantages of using semiautomat... more ABSTRACT The purpose of this paper is to demonstrate the clinical advantages of using semiautomatic volume registration where automatic registration is problematic due to large deformations, small bone anatomy, or extraneous structures. Examples are drawn from clinical cases of MRI/PET breast studies, CT angiography/SPECT cardiac studies, and total wrist arthroplasty. These types of studies should be contrasted with those involving the head, thorax, and pelvis where there is much less deformation and the existence of (some) large bones facilitates automatic matching.

Pacs User Level Requirements

Proceedings of the Society of Photo Optical Instrumentation Engineers, May 16, 1983

ABSTRACT We discuss the requirements of a Picture Archiving and Communication System (PACS) for m... more ABSTRACT We discuss the requirements of a Picture Archiving and Communication System (PACS) for medical, from the user level. Based on the current requirements and current inadequacies with film file rooms, and anticipated future requirements, we suggest a minimal set of operation classes that a working PACS must support. No specific command set is proposed; each class is discussed purely in terms of what functions it provides to the user.

New Data Products Available at the IRIS Data Management Center

With USArray data processing and services in full production, the IRIS Data Management Center (DM... more With USArray data processing and services in full production, the IRIS Data Management Center (DMC) has developed an online tool to function as a library for products derived from raw USArray observations as well as other catalogs with broad interest produced and supplied by the geoscience community. The service, called SPADE, is a flexible, annotated cataloging system for storing heterogeneous data products supplied by registered providers. SPADE includes a web interface that allows users to search across the spectrum of varied data products using geographic, temporal, and/or keyword parameters to locate products of specific interest. In addition to cooperative product submissions from outside institutions, the IRIS DMC is collaborating and developing frameworks to produce and to provide interesting products that take advantage of data from USArray sensors. These products are automatically produced in near- real time following interesting seismic events, and broaden the range of information that IRIS delivers to the geoscience community. In this presentation we will demonstrate the SPADE query interface and present examples of the available data products such as Global Centroid Moment Tensor solutions from Harvard and Columbia Universities, historic earthquake data scanned from select WWSSN film chips, as well as IRIS-produced seismic record sections, and ground-motion animations derived from Transportable Array observations.

Comparison of two landmark based image registration methods for use with a body atlas

A Message-Based Information Handling System

Compcon, 1984

Computed tomography analysis of radiostereometric data to determine flexion axes after total joint replacement: Application to the elbow joint

Journal of Biomechanics, Jul 20, 2010

Kinematic analysis for in vivo assessment of elbow endoprostheses requires knowledge of the exact... more Kinematic analysis for in vivo assessment of elbow endoprostheses requires knowledge of the exact positions of motion axes relative to bony landmarks or the prosthesis. A prosthesis-based reference system is required for comparison between individuals and studies. The primary aim of this study was to further develop an earlier described algorithm for fusion of radiostereometric analysis (RSA) data and data obtained in 3D computed tomography (CT) for application to the elbow after total joint replacement. The secondary aim was to propose a method for marking of prostheses in 3D CT, enabling definition of a prosthesis-based reference system. Six patients with elbow endoprostheses were investigated.

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Clinical Applications from Head to Toe Using a Semiautomatic 3D Inter/Intramodality Fusion Technique

Lecture Notes in Computer Science, 2003

Automated image registration techniques, particularly between modalities which clearly display an... more Automated image registration techniques, particularly between modalities which clearly display anatomy and especially within the head, have become commonplace. Meanwhile advances in molecular imaging and the need to perform registration in other areas of body has driven the development of non-rigid and semiautomatic 3D volume fusion methods. This paper will focus on this latter class of 3D volume registration methods for a variety of clinical applications.

A New CT Method for Assessing 3D Movements in Lumbar Facet Joints and Vertebrae in Patients before and after TDR

BioMed Research International, 2015

This study describes a 3D-CT method for analyzing facet joint motion and vertebral rotation in th... more This study describes a 3D-CT method for analyzing facet joint motion and vertebral rotation in the lumbar spine after TDR. Ten patients were examined before and then three years after surgery, each time with two CT scans: provoked flexion and provoked extension. After 3D registration, the facet joint 3D translation and segmental vertebral 3D rotation were analyzed at the operated level (L5-S1) and adjacent level (L4-L5). Pain was evaluated using VAS. The median (±SD) 3D movement in the operated level for the left facet joint was 3.2 mm (±1.9 mm) before and 3.5 mm (±1.7 mm) after surgery and for the right facet joint was 3.0 mm (±1.0 mm) before and 3.6 mm (±1.4 mm) after surgery. The median vertebral rotation in the sagittal plane at the operated level was 5.4° (±2.3°) before surgery and 6.8° (±1.7°) after surgery and in the adjacent level was 7.7° (±4.0°) before and 9.2° (±2.7°) after surgery. The median VAS was reduced from 6 (range 5-8) to 3 (range 2-8) in extension and from 4 (range 2-6) to 2 (range 1-3) in flexion.

A Portable, Network-Transparent Communication System for Message-Based Applications

Icdcs, 1986

Abstract A portable, network-transparent communication system (NTCS) has been developed, which su... more

A portable, network-transparent communication system for message-based applications

Proc. of the 6th International Conference on …, 1986

A portable, network-transparent communication system (NTCS) has been developed, which supports th... more

Model studies on segmental movement in lumbar spine using a semi-automated program for volume fusion

Computer aided surgery : official journal of the International Society for Computer Aided Surgery, 2008

Can Na18F PET/CT Be Used to Study Bone Remodeling in the Tibia When Patients Are Being Treated with a Taylor Spatial Frame?

by Michael Zeleznik and Henrik Lundblad

Scientific World Journal, 2014

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The KTeV hardware cluster counter

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 1996

Download

Standard Orientation of the Pelvis: Validation on a Model and Ten Patients

Acta Radiologica, 2005

Stability of Acetabular Axis after Total Hip Arthroplasty, Repeatability Using CT and A Semiautomated Program for Volume Fusion

Acta Radiologica, 2003

Purpose: To validate a CT method for detecting changes in acetabular cup orientation after THA.

Download

Model Studies on Acetabular Component Migration in Total Hip Arthroplasty using Ct and a Semiautomated Program for Volume Merging

Acta Radiologica, 2003

Purpose: Validation of a non-invasive CT method for detection of acetabular cup migration after t... more

Download

Spatial component position in total hip arthroplasty: Accuracy and repeatability with a new CT method

Acta Radiologica, 2003

Purpose: 3D detection of centerpoints of prosthetic cup and head after total hip arthroplasty (TH... more

Download

Acetabular component migration in total HIP arthroplasty using CT and a semiautomated program for volume merging

Acta Radiologica, 2002

Purpose: To develop a non-invasive method for detection of acetabular cup

Download

A new technique for diagnosis of acetabular cup loosening using computed tomography: Preliminary experience in 10 patients

Acta Orthopaedica, 2008

Accuracy and Precision of Three-Dimensional Low Dose CT Compared to Standard RSA in Acetabular Cups: An Experimental Study

BioMed research international, 2016

Clinical Application of a Semiautomatic 3D Fusion Tool Where Automatic Fusion Techniques Are Difficult to Use

Proceedings of the Third International Conference on Biomedical Image Registration, 2006

Pacs User Level Requirements

Proceedings of the Society of Photo Optical Instrumentation Engineers, May 16, 1983

New Data Products Available at the IRIS Data Management Center

Comparison of two landmark based image registration methods for use with a body atlas

A Message-Based Information Handling System

Compcon, 1984

Computed tomography analysis of radiostereometric data to determine flexion axes after total joint replacement: Application to the elbow joint

Journal of Biomechanics, Jul 20, 2010

Download

Clinical Applications from Head to Toe Using a Semiautomatic 3D Inter/Intramodality Fusion Technique

Lecture Notes in Computer Science, 2003

A New CT Method for Assessing 3D Movements in Lumbar Facet Joints and Vertebrae in Patients before and after TDR

BioMed Research International, 2015

Michael Zeleznik

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