Papers by Omar Shawkataly
Journal of Biomolecular Structure and Dynamics, 2016
VEGF and its co-receptor neuropilin-1 (NRP-1) are important targets of many pro-angiogenic factor... more VEGF and its co-receptor neuropilin-1 (NRP-1) are important targets of many pro-angiogenic factors. In this study, nine peptides were synthesized and evaluated for their molecular interaction with NRP-1 and compared to our previous peptide ATWLPPR. Docking study showed that the investigated peptides shared the same binding region as shown by tuftsin known to bind selectively to neuropilin-1. Four pentapeptides (DKPPR, DKPRR, TKPPR and TKPRR) and a hexapeptide CDKPRR demonstrated good inhibitory activity against NRP-1. In contrast, peptides having arginine residue at sites other than the C-terminus exhibited low activity towards NRP-1 and this is confirmed by their inability to displace the VEGF165 binding to NRP-1. Docking study also revealed that replacement of carboxyl to amide group at the C-terminal arginine of the peptide did not affect significantly the binding interaction to NRP-1. However, the molecular affinity study showed that these peptides have marked reduction in the activity against NRP-1. Pentapeptides having C-terminal arginine showed strong interaction and good inhibitory activity with NRP thus may be a good template for anti-angiogenic targeting agent.
Acta Crystallographica Section E Structure Reports Online, 2010
l-Bis(diphenylarsino)methane-1:2j 2 As:
Acta Crystallographica Section E Structure Reports Online, 2010
l-Bis(diphenylarsino)methane-1:2j 2 As:
Acta Crystallogr E Struct Rep, 2009
l-Bis(diphenylphosphino)methane-1:2j 2 P:P 0 0 0 ]nonacarbonyl-1j 3 C,2j 3 C,3j 3 C-[tris(4-methy... more l-Bis(diphenylphosphino)methane-1:2j 2 P:P 0 0 0 ]nonacarbonyl-1j 3 C,2j 3 C,3j 3 C-[tris(4-methylphenyl)arsine-3jAs]-triangulo-triruthenium(0)
Acta Crystallographica Section E Structure Reports Online, 2009
l-Bis(diphenylarsino)methane-1:2j 2 As:
Acta Crystallographica Section E Structure Reports Online, 2010
Bis([l-bis(diphenylarsino)methane-1:2j 2 As:As']nonacarbonyl-1j 3 C,2j 3 C,3j 3 C-{tris[4-(methyl... more Bis([l-bis(diphenylarsino)methane-1:2j 2 As:As']nonacarbonyl-1j 3 C,2j 3 C,3j 3 C-{tris[4-(methylsulfanyl)phenyl]arsine-3jAs}-triangulotriruthenium(0)) dichloromethane monosolvate Key indicators: single-crystal X-ray study; T = 100 K; mean (C-C) = 0.003 Å; disorder in solvent or counterion; R factor = 0.023; wR factor = 0.059; data-toparameter ratio = 29.5.
New Journal of Chemistry, 1988
Acta Crystallographica Section C Crystal Structure Communications, 1993
Acta Crystallographica Section E Structure Reports Online, 2009
Key indicators: single-crystal X-ray study; T = 100 K; mean (C-C) = 0.007 Å; R factor = 0.048; wR... more Key indicators: single-crystal X-ray study; T = 100 K; mean (C-C) = 0.007 Å; R factor = 0.048; wR factor = 0.133; data-to-parameter ratio = 22.5. metal-organic compounds m1624 Shawkataly et al.
Acta Crystallographica Section E Structure Reports Online, 2010
l-Bis(diphenylarsino)methane-1:2j 2 As:As 0 0 0 ][(4-bromophenyl)diphenylphosphine-3jP]nonacarbon... more l-Bis(diphenylarsino)methane-1:2j 2 As:As 0 0 0 ][(4-bromophenyl)diphenylphosphine-3jP]nonacarbonyl-1j 3 C,2j 3 C,3j 3 C-triangulo-triruthenium(0) chloroform 0.3-solvate Key indicators: single-crystal X-ray study; T = 296 K; mean (C-C) = 0.010 Å; disorder in solvent or counterion; R factor = 0.048; wR factor = 0.169; data-toparameter ratio = 24.4.
Journal of Organometallic Chemistry
ABSTRACT
Acta Crystallographica Section E Structure Reports Online
l-Bis(diphenylphosphino)methane-1:2j 2 P:P 0 0 0 ]nonacarbonyl-1j 3 C,2j 3 C,3j 3 C-[tris(4-methy... more l-Bis(diphenylphosphino)methane-1:2j 2 P:P 0 0 0 ]nonacarbonyl-1j 3 C,2j 3 C,3j 3 C-[tris(4-methylphenyl)arsine-3jAs]-triangulo-triruthenium(0)
Acta Crystallographica Section E Structure Reports Online
Bis{[l-bis(diphenylarsino)methane-1:2j 2 As:As 0 0 0 ]nonacarbonyl-1j 3 C,2j 3 C,-3j 3 C-[tris(4-... more Bis{[l-bis(diphenylarsino)methane-1:2j 2 As:As 0 0 0 ]nonacarbonyl-1j 3 C,2j 3 C,-3j 3 C-[tris(4-chlorophenyl)phosphine-3jP]-triangulo-triruthenium(0)} chloroform monosolvate Key indicators: single-crystal X-ray study; T = 100 K; mean (C-C) = 0.009 Å; R factor = 0.043; wR factor = 0.092; data-to-parameter ratio = 21.5.
Acta Crystallographica Section E Structure Reports Online
Key indicators: single-crystal X-ray study; T = 100 K; mean (C-C) = 0.005 Å; R factor = 0.040; wR... more Key indicators: single-crystal X-ray study; T = 100 K; mean (C-C) = 0.005 Å; R factor = 0.040; wR factor = 0.111; data-to-parameter ratio = 22.8.
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Papers by Omar Shawkataly