Papers by Jalloul Bouajila
Journal of Medical and Bioengineering, 2013
Abstract-The Globularia alypum methanolic extract (GAME) was evaluated for the anticholinestera... more Abstract-The Globularia alypum methanolic extract (GAME) was evaluated for the anticholinesterase, anti 5lipoxygenase, NO production inhibitory activities and the transcriptional regulation pathway. Interestingly, GAME showed an important anti-inflammatory activity in a dose dependant manner, and inhibited nitric oxide (NO) production via transcriptional regulation of iNOS gene by (66%) at 150mg/L in IFN-γ/LPS stimulated RAW 264.7 macrophages. In addition, both Globularia alypum showed a 5-Lipoxygenase inhibitory activity with IC 50 value of 79±0.8mg/L. Acetyl-cholinesterase inhibition was assessed by modification of the Ellman's method. Globularia alypum exhibited a strong activity against cholinesterase with IC 50 value 9.33±0.47mg/L. The data suggest that Globularia alypum extract could be used as a natural inhibitor of oxidation and alzheimer disease, and since GAME induced a potent anti-inflammatory suggest its potent use for the treatment of inflammatory diseases.
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Papers by Jalloul Bouajila